Protein Alignment Pgant1 and GALNT3

DIOPT Version :10

• Sequence 1: NP_611043.1
• Gene: Pgant1 / 36717
• FlyBaseID: FBgn0034025
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_004473.2
• Gene: GALNT3 / 2591
• HGNCID: 4125
• Length: 633
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 218/602 - (36%)
• Similarity: 309/602 - (51%)
• Gaps: 88/602 - (14%)

  Fly    28 VQQNGSPEEPPVAPLVRAAALRGHGRERFEAYSDSENEIARPATQSPYE------------QIIQ 80
            |:||....|.|        .|:|:       |:.:|   .:|....|.:            :...
Human    86 VRQNIDAGERP--------CLQGY-------YTAAE---LKPVLDRPPQDSNAPGASGKAFKTTN 132

  Fly    81 LDLQKQKVGLGEQGVAVHLSGAAKERGDEIYKKIALNEELSEQLTYNRSVG-DHRNPLCAKQRFD 144
            |.:::||               .||||:   .|...|...|::::.:|.:| |.|.|.|.:|:|.
Human   133 LSVEEQK---------------EKERGE---AKHCFNAFASDRISLHRDLGPDTRPPECIEQKFK 179

  Fly   145 -SDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNVELGAKLDYYVRTRI 208
             ...|||.||:|:|.||.:|.|||||||.|.:.....|||||||||.|.:..|..|||.||:
Human   180 RCPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLKEIILVDDASVDEYLHDKLDEYVK--- 241

  Fly   209 PSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCEPLLQRIKESRTSVLVPII 273
            ....|.|:|.:.|.|||.|||.||.:||.:.|.|||||||...||.||||.||.|:.|:|:.|.|
Human   242 QFSIVKIVRQRERKGLITARLLGATVATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDI 306

  Fly   274 DVIDANDFQ------YSTNGYKSFQVGGFQWNGHFDWINLPEREKQRQRRECKQEREICPAYSPT 332
            ..||.|.|:      |.:|..:    |.|.|:..|.|.:||:.||||::      .|..|..:||
Human   307 ASIDLNTFEFNKPSPYGSNHNR----GNFDWSLSFGWESLPDHEKQRRK------DETYPIKTPT 361

  Fly   333 MAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFRDFHPYKFP 397
            .|||||:|.:.||..:|||||:|:.|||||:|||||:|||||.:|.:|||.|||:||...|:.||
Human   362 FAGGLFSISKEYFEYIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHSFP 426

  Fly   398 NDRDTHGINTARMALVWMDEYINIFFLNRPD----LKFHADIGDVTHRVMLRKKLRCKSFEWYLK 458
            ........|..|:|.||||||..||:....|    :|..| .||::.|..::.:|:||:|.|||.
Human   427 KGTQVIARNQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKA-FGDLSKRFEIKHRLQCKNFTWYLN 490

  Fly   459 NIYPEKFVPTKDVQGWGKVHAVNSNICLDDLLQNNEKPYNAGLYPCGKVLQKSQLFSFTNTNVLR 523
            |||||.:||..:....|.:.:|...:|| |:.:||:......:|.| ..|..:|.|.::..:.:|
Human   491 NIYPEVYVPDLNPVISGYIKSVGQPLCL-DVGENNQGGKPLIMYTC-HGLGGNQYFEYSAQHEIR 553

  Fly   524 NELSCATVQHSESPPYRVVMVPCMENDE----FNEQ-WRYEHQHIIHSN-TGMCLDHQGLKSLDD 582
            :.:......|:...  .|.:..|.....    ..|| |..:...::::. ..|||...|    :.
Human   554 HNIQKELCLHAAQG--LVQLKACTYKGHKTVVTGEQIWEIQKDQLLYNPFLKMCLSANG----EH 612

  Fly   583 AQVAPCDPHSESQRWTI 599
            ..:..|:|....|:|.:
Human   613 PSLVSCNPSDPLQKWIL 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	pp-GalNAc-T	152..461	CDD:133004	153/318 (48%)
		beta-trefoil_Ricin_Pgant1-like	468..601	CDD:467337	27/138 (20%)
GALNT3	NP_004473.2	Catalytic subdomain A	184..293		62/111 (56%)
		pp-GalNAc-T	188..493	CDD:133004	153/318 (48%)
		Catalytic subdomain B	356..418		39/61 (64%)
		beta-trefoil_Ricin_GALNT3	502..630	CDD:467346	27/136 (20%)