Protein Alignment Pgant1 and GALNT1

DIOPT Version :10

• Sequence 1: NP_611043.1
• Gene: Pgant1 / 36717
• FlyBaseID: FBgn0034025
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_065207.2
• Gene: GALNT1 / 2589
• HGNCID: 4123
• Length: 559
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 228/557 - (40%)
• Similarity: 319/557 - (57%)
• Gaps: 55/557 - (9%)

  Fly    61 DSENEIARPA------TQSPYEQIIQLDLQKQKVGLGEQGVAVHLSGAAKERGDEIYKKIALNEE 119
            |.:.|...||      .|.|:|            |.||.|..|.:....:|:..|::|....|..
Human    35 DEKKERGLPAGDVLEPVQKPHE------------GPGEMGKPVVIPKEDQEKMKEMFKINQFNLM 87

  Fly   120 LSEQLTYNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEI 184
            .||.:..|||:.|.|...| |.:...|:|||.||||:|.||.:|.|||||||.::......::||
Human    88 ASEMIALNRSLPDVRLEGC-KTKVYPDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEI 151

  Fly   185 ILVDDGSDNVELGAKLDYYV-RTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCE 248
            :||||.|:...|...|:.|| :.::|   |.::|::.|.|||||||.||.::.|.|:.|||||||
Human   152 VLVDDASERDFLKRPLESYVKKLKVP---VHVIRMEQRSGLIRARLKGAAVSKGQVITFLDAHCE 213

  Fly   249 GNIGWCEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPEREKQ 313
            ..:||.||||.|||..|.:|:.||||||..:.|:|......::  |||.|..:|.|..:|:||..
Human   214 CTVGWLEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTY--GGFNWKLNFRWYPVPQREMD 276

  Fly   314 RQRRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIET 378
            |:    |.:|.: |..:||||||||:|||.||.|:|:||..||.|||||||:||||||||||:|.
Human   277 RR----KGDRTL-PVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEI 336

  Fly   379 IPCSRVGHIFRDFHPYKFPNDRDTHGI---NTARMALVWMDEYINIFFLNRPDLKFHADIGDVTH 440
            :.||.|||:||...||.||.  .|..|   |..|:|.|||||:.|.|::..|.:. ..|.||::.
Human   337 VTCSHVGHVFRKATPYTFPG--GTGQIINKNNRRLAEVWMDEFKNFFYIISPGVT-KVDYGDISS 398

  Fly   441 RVMLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKVHAVNSNICLDDLL-QNNEKPYNAGLYPC 504
            ||.||.||:||.|.|||:||||:..:| :.....|::..|.:|.|||::. :.|||   .|::.|
Human   399 RVGLRHKLQCKPFSWYLENIYPDSQIP-RHYFSLGEIRNVETNQCLDNMARKENEK---VGIFNC 459

  Fly   505 GKVLQKSQLFSFTNTNVLRNELSCATVQHSESPPYRVVMVPCMENDEFNEQWRYEHQHII--HSN 567
             ..:..:|:||:|....:|.:..|..|.....|   |.|:.| .:.:.|:.|.|:...:.  |.|
Human   460 -HGMGGNQVFSYTANKEIRTDDLCLDVSKLNGP---VTMLKC-HHLKGNQLWEYDPVKLTLQHVN 519

  Fly   568 TGMCLDHQGLKSLDDAQV---APCDPHSESQRWTIEH 601
            :..|||.   .:.:|:||   ..|: .|.||:|.:.:
Human   520 SNQCLDK---ATEEDSQVPSIRDCN-GSRSQQWLLRN 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	pp-GalNAc-T	152..461	CDD:133004	157/312 (50%)
		beta-trefoil_Ricin_Pgant1-like	468..601	CDD:467337	38/138 (28%)
GALNT1	NP_065207.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..65		7/31 (23%)
		Catalytic subdomain A	115..225		57/112 (51%)
		pp-GalNAc-T	119..419	CDD:133004	157/312 (50%)
		Catalytic subdomain B	285..347		43/61 (70%)
		beta-trefoil_Ricin_GALNT1	426..552	CDD:467344	38/137 (28%)