DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Arf6 and SAR1B

DIOPT Version :10

Sequence 1:NP_523751.2 Gene:Arf6 / 36699 FlyBaseID:FBgn0013750 Length:175 Species:Drosophila melanogaster
Sequence 2:NP_057187.1 Gene:SAR1B / 51128 HGNCID:10535 Length:198 Species:Homo sapiens


Alignment Length:176 Identity:59/176 - (33%)
Similarity:94/176 - (53%) Gaps:24/176 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 KEMRILMLGLDAAGKTTILYKLK---LGQSVTTI-PTVGFNVETVTYKNVKFNVWDVGGQDKIRP 72
            |..:::.||||.|||||:|:.||   |||.|.|: ||    .|.:|...:.|..:|:||..:.|.
Human    24 KTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT----SEELTIAGMTFTTFDLGGHVQARR 84

  Fly    73 LWRHYYTGTQGLIFVVDCADRDRIDEARTELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQE 137
            :|::|.....|::|:|||||.:|:.|::.||..::.|..:.:..|||..||.|.|:|:....::|
Human    85 VWKNYLPAINGIVFLVDCADHERLLESKEELDSLMTDETIANVPILILGNKIDRPEAISEERLRE 149

  Fly   138 KLGL---------TRIRDRNWYVQP----SCAT-SGDGLSEGLIWL 169
            ..||         ..:::.|  .:|    .|:. ...|..||..|:
Human   150 MFGLYGQTTGKGSISLKELN--ARPLEVFMCSVLKRQGYGEGFRWM 193

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Arf6NP_523751.2 P-loop containing Nucleoside Triphosphate Hydrolases 1..174 CDD:476819 59/176 (34%)
SAR1BNP_057187.1 Sar1 3..197 CDD:206645 59/176 (34%)
STAR, SAR1-N-terminal activation recruitment. Required for the activation by PREB and subsequent recruitment to ER membrane. /evidence=ECO:0000250|UniProtKB:Q9QVY3 3..5
Mediates recruitment to ER membranes. /evidence=ECO:0000250|UniProtKB:Q9QVY3 15..19
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.