Protein Alignment Trpm and TRPM3

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_001353076.1
• Gene: TRPM3 / 80036
• HGNCID: 17992
• Length: 1744
• Species: Homo sapiens
• Alignment Length: 1906
• Identity: 714/1906 - (37%)
• Similarity: 1004/1906 - (52%)
• Gaps: 386/1906 - (20%)

  Fly    10 QKPKAKPIPWGLKKICWG--LINITVPRHQPRSWIETNFQKRECIKFIPCPKDDTKCCCGQAQIT 72
            |....:|:.|.::|:|..  |.::.:.:.| :||||..|.||||:..||..||..:||||:....
Human    32 QADAPRPLNWTIRKLCHAAFLPSVRLLKAQ-KSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQ 95

  Fly    73 HQTI-PGI--------ESG-SPGDL----WLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSF 123
            |..: |.|        ||. |..|:    |..:|||:..||||:||||||||.|..||.|||:||
Human    96 HVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSF 160

  Fly   124 DTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNT 188
            ||:|:||:.|.||||.||||||||:|.||..||:||.|||:...|||:|||.||||||||||.||
Human   161 DTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNT 225

  Fly   189 GVTKQVGDALLLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHA 253
            ||.:.|||||.....:..|::.:||||||||||...:|:|.:...|..::|:|.|||.|||:.|:
Human   226 GVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHS 290

  Fly   254 YFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPS------------KNHW----LKTNVTHSST 302
            :|:|.||||..|||||:.|||:|||.||..|::..            .:.|    |.:.......
Human   291 HFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDSRLFYSFWGSCQLDSVGIGQGV 355

  Fly   303 PVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYL 367
            |||.|::|||.|.|..||||:.|:||||||||||||||:|:|||.|||:.:|  ..:.||:||.|
Human   356 PVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEG--GLINESLRDQL 418

  Fly   368 IGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPP 432
            :.||||||.....|::.|:..|::|.:.|.||||||:..  ||. |::|..|||||.|..:.|.|
Human   419 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGS--EGH-QDIDLAILTALLKGANASAP 480

  Fly   433 EQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPR 497
            :||||||.|||||||||:||:|||:||.|:|::||:.||..||:||||||:||||||.:||||.|
Human   481 DQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISR 545

  Fly   498 LEELYNTKHGPANTLGYILRDVRP-------------HIPKGYIYTLHDIGLVINKLMGGAYRSY 549
            |||||||:|||:|||.:::|||:.             ::|..|..:|.||||||..|||||||..
Human   546 LEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCN 610

  Fly   550 YTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMAL------------ 602
            |||::||.:|..:.........|                    ||....::.|
Human   611 YTRKRFRTLYHNLFGPKRPKALK--------------------LLGMEDDIPLRRGRKTTKKREE 655

  Fly   603 -------------FEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAED 654
                         |.|||:||::||||.|||:|||..|.|||||:||:||:|||.|||||||:|:
Human   656 EVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASEN 720

  Fly   655 DLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALL 719
            |:..:|.:||...:::|.....:|||.||:||.:.|.:|||.||.:|||.:||.|||||.||..:
Human   721 DMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFI 785

  Fly   720 AHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLD 784
            ||.|||::|.|:|||.||.|||:..|||||:.:|..|..|:||:|:::..|.|.:|.||:.:..:
Human   786 AHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAE 850

  Fly   785 NDDSDRSQPDAESALLKAKRSISLRYRMGAGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTA 849
            ..:....:.:.|...|.|.          .|.||.:.:...|...|:
Human   851 EPEKPTKEKEEEDMELTAM----------LGRNNGESSRKKDEEEVQ------------------ 887

  Fly   850 QFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRW 914
                          .:|:.:.|.:|.||||.|||.|||..::||:.:|::|::.||||||:.|..
Human   888 --------------SKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPST 938

  Fly   915 QEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTM- 978
            |||..|:||.|||.||:|||:.|||..:..|..||....||..|..||:||.:|:..|.::...
Human   939 QEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFR 1003

  Fly   979 DIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILY 1043
            ..|||||||:.||||:|:|:|.||||||||.|.|:|||:.:|:|||:::.||||||||:|||||:
Human  1004 SDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILF 1068

  Fly  1044 PNKQPTWSLIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAA 1108
            ||::|:|.|.|
Human  1069 PNEEPSWKLAK------------------------------------------------------ 1079

  Fly  1109 TTSTTAPIHNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDIDPPCGEDPSQ--------PGCVTGH 1165
                                 |:.:.||:|:||||||..||||||::.::        |.|.||.
Human  1080 ---------------------NIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGA 1123

  Fly  1166 WVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIAL 1230
            |:.|..|:.|||:|||||:|||||||||.|.||.|:|:|||.|||:.::|.:.::||||||.|..
Human  1124 WIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIF 1188

  Fly  1231 CHFYSLLKY-CV--RKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDE 1292
            .|...:.:: |.  ||.:....:||.|||||:..|:|::::||||:|:|.:|.|::...|.|.||
Human  1189 SHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDE 1253

  Fly  1293 RVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLA-VIHRFMSTHTAG 1356
            |::.|:||||.||.::|::|::|:...|::|.::.||.::|:    ::..:| .:.|......|.
Human  1254 RIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED----LIGRMATALERLTGLERAE 1314

  Fly  1357 ADDLRGST-INIPGEMQRMRTISISDTEGGS-------GPGGNGGGGGGGGAIVPLGLGAGLNLN 1413
            ::.:|..| .:.......:|..|.:..||.:       .|.|..........::|
Human  1315 SNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMP---------- 1369

  Fly  1414 SLQVTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSE--- 1475
                   |..:.|...|.    :.|:|.       .|:.:.:.|.|.....:.....|:..|
Human  1370 -------RMRSHSFYSVN----MKDKGG-------IEKLESIFKERSLSLHRATSSHSVAKEPKA 1416

  Fly  1476 ----ADSDIYIPVSQRPSTCETVKRTPYVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDD 1536
                |::...:|.|:|||:|..:    ||:      |..|....:.|:   |:...::|......
Human  1417 PAAPANTLAIVPDSRRPSSCIDI----YVS------AMDELHCDIDPL---DNSVNILGLGEPSF 1468

  Fly  1537 ATPDINFEAARHRALRQRTVSLCRRNSETYSL---TGADINRSHISLNQLASLSRRQMS-----L 1593
            :||                |.....:|..|:.   |....:|| |....:.|:..|..|     |
Human  1469 STP----------------VPSTAPSSSAYATLAPTDRPPSRS-IDFEDITSMDTRSFSSDYTHL 1516

  Fly  1594 TQSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNI-----------LLKLHS--------------- 1632
            .:.:...|.:.|:..       ::..:|.||.:           ::|.||
Human  1517 PECQNPWDSEPPMYH-------TIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGV 1574

  Fly  1633 -----EYTSITDELESVCHMIASP--------------------TVSLPSNKASLDRPKTEMSRA 1672
                 |||||||.:::.|  :.:|                    |...|..:|.|..|.::....
Human  1575 PVKTAEYTSITDCIDTRC--VNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEEN 1637

  Fly  1673 EAAALLEKKHLKECE-ENDYMILEG-----LIESRGSIDA---SAQGFEIGVSIDYSHRYPLRRE 1728
            ||........:...| :|....|..     .||...|..|   ||.......|...|.:...:|.
Human  1638 EAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRN 1702

  Fly  1729 TAVELSP------SKPSVDGD 1743
            ||...:|      |||...||
Human  1703 TASLRNPFQRSKSSKPEGRGD 1723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	154/291 (53%)
		TRPV	<872..1227	CDD:454755	158/363 (44%)
		TRPM_tetra	1291..1346	CDD:465156	19/55 (35%)
TRPM3	NP_001353076.1	LSDAT_euk	153..443	CDD:465665	154/291 (53%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:J9SQF3	192..215		14/22 (64%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:J9SQF3	300..323		14/22 (64%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:J9SQF3	613..636		6/42 (14%)
		Required for the inhibitory action of G-beta/gamma-subunits of heterotrimeric G-proteins. /evidence=ECO:0000250|UniProtKB:J9SQF3	629..637		3/27 (11%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:J9SQF3	805..828		11/22 (50%)
		TRPV	<906..1224	CDD:454755	165/392 (42%)
		TRPM_tetra	1252..1307	CDD:465156	19/58 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1471..1490		5/34 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1623..1744		25/101 (25%)