Protein Alignment Trpm and trpm2

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_009303267.2
• Gene: trpm2 / 799412
• ZFINID: ZDB-GENE-061214-4
• Length: 1474
• Species: Danio rerio
• Alignment Length: 1687
• Identity: 444/1687 - (26%)
• Similarity: 724/1687 - (42%)
• Gaps: 398/1687 - (23%)

  Fly    40 SWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSP----GDLWLPTKHTRPQPTD 100
            |||:.|.:|:||..::...::.. |.||..::.|..    |:..|    |:.|...:|.|..|||
Zfish    42 SWIKENIKKKECCFYVEDGREGI-CKCGYPKVQHCD----EAIKPEDYMGEQWDKHRHVRETPTD 101

  Fly   101 AYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKE 165
            |:|.|.| ||......:|||:|.||..|.|.||.|::|.|..|.|||:|.||..||.::..||.:
Zfish   102 AFGDISF-GGLGQKTGKYVRVSSDTSCENLYQLMTEQWKLRSPNLLISVTGGAKNFYIKTHLKDK 165

  Fly   166 IRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDAL---LLEGQQRTGRVVSIGIAPWGIVERNHELL 227
            .|:||:|.|:||||||.||||:.||.|.||.|:   .|......|::|.||:||||::.....|:
Zfish   166 FRRGLIKVAQTTGAWILTGGTHAGVMKHVGMAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRSTLI 230

  Fly   228 GHNREVPC-HSISSP-RSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPSKN 290
            ......|. :|:... :.:|:.|:..|.:|||||:|||..||.|:.||.:|||.||.|.|...
Zfish   231 HPEGRFPAYYSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVEIELRARLEKLISKLSLGNR-- 293

  Fly   291 HWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGE 355
               ::.||   .||||:|::||..|:..:...:.:.  .|.||.:||||.||::|.|       .
Zfish   294 ---ESGVT---IPVVCVVLDGGPGTLNTIYNSMLNH--TPCVVLEGSGRLADVIAHV-------A 343

  Fly   356 EQPVLESMRDYLIGTIQKTF---------EVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGE 411
            ..|| ..:...||..:.|.|         |:.:.:..|..|:::   |..:|:|||||.   |.:
Zfish   344 SVPV-SKVTMALINRLLKRFFLQEYKNFTELQIIEWTKKIQDIM---RMPHLLTVFRID---EDK 401

  Fly   412 AQELDQTILTALFKS----QHLSP---PEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQ 469
            ..::|..||.||.|:    :|...   ..||.||:.|||||||.||||....:|.:..|..||..
Zfish   402 NYDVDVAILQALLKASRSDEHAGRHCWERQLELAVAWNRVDIAESEIFTEESQWTSSDLHPAMFS 466

  Fly   470 ALEHDRIDFVKLLLENGVSMKKFLTIPR-LEELYNTKHGPA---------NTLGYILRDVRPHIP 524
            ||..|:.:||:|||||||.:::||.... |.|||:  |.|:         ...|..:|..:..:|
Zfish   467 ALVGDKPEFVRLLLENGVCVREFLEREETLCELYS--HLPSCFFLRKLAKRVQGGKMRRGQEPLP 529

  Fly   525 KGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRP----IYAKVMNSYANACRKSSTYQYQRYAGAN 585
            ......|..:...:..|:|...:..|...:::|    :..||.:.                 ||.
Zfish   530 GSRKVCLSHVSEEVRHLLGSFTQPLYIASRYKPTKDDVRLKVPSK-----------------GAL 577

  Fly   586 SLSLVTGLLPFTSEMALFEF-------PFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKL 643
            .       ||.:.|    |:       |..:|.:|||:...:::|.:.|....:.:|.:|.:.|:
Zfish   578 D-------LPCSGE----EWSADTVWDPGRDLFLWAVVQNNRELAEIGWEQCRDCIAAALAASKI 631

  Fly   644 YKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLS 708
            .:.:|.|:.||  |:|...|:...|..:|.:...:....:..||::||:||.....||...:||.
Zfish   632 LRKLAQESGED--DSEEATEMLELANHYEKQAIGVFSECHSWDAQRAQKLLIRISPSWGRSTCLW 694

  Fly   709 LAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPF----YIRQLDFKSKEELQ- 768
            ||:.|:.::.:||...|.:|..:|.|.|.. .|.::||:  |.|.|    |...|.|:..|::|
Zfish   695 LALEAHDKSFIAHSGVQALLTQIWCGELSV-DNPHWKVL--LCMIFFPLIYTGFLTFRRDEDIQR 756

  Fly   769 QMPQTEEEHLENQNLDNDDSDRSQPDAESALLKAKRSISLRYRMGAGANNRDKALLADTYSVRDT 833
            |..:||::.|..:::....||
Zfish   757 QAERTEQQKLAMESVFAGQSD-------------------------------------------- 777

  Fly   834 KVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLI 898
                 ||:.         |.....|:.:|:|   ||....:...|..:|..||:.:..:|..||.
Zfish   778 -----GKIK---------RHLRGFSQKSELK---PLNCSSRLMSFLKSPQVKFYWNIASYFGFLW 825

  Fly   899 MFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISS-EPVAITHKFSVWAWNMWNPCDGAAI 962
            :|:..:::..:..|.|:|.....::|:|..|::|::... :......|..::..::||..|..:|
Zfish   826 LFAVVLMIDFQTSPSWRELLLYVWLTSLVCEEIRQLYHDFDGSGFRRKAKMYIKDLWNILDVLSI 890

  Fly   963 ILFVIGLAFRFR--ENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVV 1025
            :||:.||..|.:  :....||:||.|:|.|.:.||::.|..:::.|||.:.::.:|:.::.:|:.
Zfish   891 VLFIAGLICRLQASDTVFYIGKVILCIDFIIFCLRLMAIFSISRTLGPKIIIVRRMMLDLFFFMF 955

  Fly  1026 LLAVVLMSFGVSRQAILYPNKQP-TWSLIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPP 1089
            ||::.::::||::|.||..|::. .|     :|.|::
Zfish   956 LLSIWVVAYGVAKQGILIENEERLNW-----IIRGAV---------------------------- 987

  Fly  1090 VTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDID----- 1149
                                                       ::||..::|. |..:||
Zfish   988 -------------------------------------------YEPYITIFGN-FPTNIDNTLFD 1008

  Fly  1150 -PPC---GEDPSQPGC---------VTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSV 1201
             ..|   ..||.:|.|         |...|:|.:.:.:|||.|||||:|||||:||..|.||...
Zfish  1009 ISSCSVNASDPLKPKCPMLNADNTPVFPEWLTIMMLCVYLLFANILLLNLLIAIFNYTFQEVQDN 1073

  Fly  1202 SHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEV----QRDNGLKLFLEKD 1262
            :..:|.|||:.::.||..:|.||||||.|.|....:       :|:.:    ||....:..||:.
Zfish  1074 TDTIWKFQRYELIKEYHSRPALPPPFILLSHLILFI-------RGVFLRDLPQRHKNFRQELEQT 1131

  Fly  1263 DLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEF 1327
            :.|.|..:|....:.:........:||.:.|:.:|.|:|..||:.:|   :::.:.:||:..
Zfish  1132 EEEELLSWEAYMKDNYLASTRQDESQSVEHRIHDTAEKVGAMSELLE---REQEMVSATMAK--- 1190

  Fly  1328 RLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTISISDTEGGSGPGGNG 1392
            ||.::||...:....|..|          .|.|:........:...||:.| ||.:.|...|
Zfish  1191 RLARLEEQVSESAKALRWI----------IDALKSQGCKSKVQPPLMRSKS-SDRDDGDSSG--- 1241

  Fly  1393 GGGGGGGAIVPLGLGAGLNLNSLQVT----TRRRFNRSLTEVRPDAYIF-----DEGTHFEVVPL 1448
                                   |.|    ....|.|.|.  .||:.:.     :|...:||...
Zfish  1242 -----------------------QETDDEEAPHMFARQLQ--YPDSTVRRFPVPEEKVSWEVNFS 1281

  Fly  1449 PEEP------DEVVKSREALNEQ--------VVRKASMQSEADSDIYIPVSQRPSTCETVKRTPY 1499
            |.:|      |.......||::.        :..|.::.:...:.|..|:..|....|. |...:
Zfish  1282 PYQPPVYNQQDSSESDTSALDKHRNPGGRTGIRGKGALNTLGPNHILHPIFTRWRDAEH-KVLEF 1345

  Fly  1500 VTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNSE 1564
            :.:.:|.                :....|:||....|.......|....:.|.::|.:|.:...|
Zfish  1346 LAIWEDA----------------EKRWALLGGPAKPDEPLAQVLERILGKKLNEKTKTLLKAGEE 1394

  Fly  1565 TY--------SLTGADINRSHISLNQLASLSRRQMSLTQSEPDSDKDAPIAQGSAHPGKSVL 1618
            .|        :...|.:..|.|:|:                  .||:.|:.....|..:|.|
Zfish  1395 VYKGYVDDSRNTDNAWVETSIITLH------------------CDKNTPLMADLNHMVESSL 1438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	110/289 (38%)
		TRPV	<872..1227	CDD:454755	93/376 (25%)
		TRPM_tetra	1291..1346	CDD:465156	14/54 (26%)
trpm2	XP_009303267.2	None