Protein Alignment Trpm and Trpm4

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_036009293.1
• Gene: Trpm4 / 68667
• MGIID: 1915917
• Length: 1254
• Species: Mus musculus
• Alignment Length: 1417
• Identity: 351/1417 - (24%)
• Similarity: 582/1417 - (41%)
• Gaps: 389/1417 - (27%)

  Fly    39 RSWIETNFQKRECIKFIPCPKDD---TKCCCGQAQITHQTIPGIESGSPGDL---WLPTKHTRPQ 97
            :|||...|:|:.|..||....||   |.|.|||.:..|.:: .:|......:   |...:||..:
Mouse   103 QSWIPKIFRKKVCTTFIVDLSDDAGGTLCQCGQPRDAHPSV-AVEDAFGAAVVTEWNSDEHTTEK 166

  Fly    98 PTDAYGTIEF--QGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQA 160
            ||||||.::|  .|..|   :.::|||..|.|..:..|.|:.|....|.|:::|.||.....||.
Mouse   167 PTDAYGDLDFTYSGRKH---SNFLRLSDRTDPATVYSLVTRSWGFRAPNLVVSVLGGSGGPVLQT 228

  Fly   161 KLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTG--RVVSIGIAPWGIVERN 223
            .|:..:|:||::||::|||||.|||.:||:.:.||.|:.......||  :||::|:||||:| ||
Mouse   229 WLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQTASTGSSKVVAMGVAPWGVV-RN 292

  Fly   224 HELLGHN----------REVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEK 278
            .::|.:.          |..|...:..|      |:..::.|.|||:||..:.|.|...|.:.|.
Mouse   293 RDMLINPKGSFPARYRWRGDPEDGVEFP------LDYNYSAFFLVDDGTYGRLGGENRFRLRFES 351

  Fly   279 FISNLKLHPSKNHWLKTNV--THSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAA 341
            :::.          .||.|  |....||:.|:|:|....::.: |..|.: .:|.::..|||.||
Mouse   352 YVAQ----------QKTGVGGTGIDIPVLLLLIDGDEKMLKRI-EDATQA-QLPCLLVAGSGGAA 404

  Fly   342 DLLAFVHKYASDGEEQPVLESMRDYLI------------GTIQKTFEVGLDQSEKLYQELLQCTR 394
            |.|               :|::.|.|.            ..|::.|..|  ..|.|..::.:...
Mouse   405 DCL---------------VETLEDTLAPGSGGLRRGEARDRIRRYFPKG--DPEVLQAQVERIMT 452

  Fly   395 NKNLITVFRIQEKPEGEAQELDQTILTALFK----SQHLSPPEQLSLALTWNRVDIARSEIFVYG 455
            .|.|:||:    ..|..::|.:..:|.||.|    |:..:..::|.||:.|||||||:||:|...
Mouse   453 RKELLTVY----SSEDGSEEFETIVLRALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGD 513

  Fly   456 QEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELY------------------ 502
            .:|.:..|:.::|.||.:||.:||:||:.:|:|:..|||..||.:||
Mouse   514 IQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPVRLAQLYSAVSPNSLIRNLLDQASH 578

  Fly   503 --NTKHGPANTLGYILRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYA----- 560
              ::|..|.|  |.:  ::||          .::|.|:..|:|......|..|..|..|.
Mouse   579 ASSSKSPPVN--GTV--ELRP----------PNVGQVLRTLLGETCAPRYPARNTRDSYLGQDHR 629

  Fly   561 ---KVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQM 622
               .::..:||  ::.||                       :.:..:.|:::|||||:|..|.||
Mouse   630 ENDSLLMDWAN--KQPST-----------------------DASFEQAPWSDLLIWALLLNRAQM 669

  Fly   623 ALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELR--SYAKEFESKGNKLLDFSYRQ 685
            |:..|..|..::|.:|.:|.|.:.||.      |::|..|..|  ..|..|||....|....|..
Mouse   670 AIYFWEKGSNSVASALGACLLLRVMAR------LESEAEEAARRKDLAATFESMSVDLFGECYHN 728

  Fly   686 DAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGL 750
            ..|:|.|||......|...:||.||:.|:.||..|....|.:|...|.|.:.: ....:.::|..
Mouse   729 SEERAARLLLRRCPLWGEATCLQLAMQADARAFFAQDGVQSLLTQKWWGEMDS-TTPIWALLLAF 792

  Fly   751 AMP--FYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAESALLKAKRSISLRYRMG 813
            ..|  .|...:.|:..|        ||...::.:.|.|.|........:....||.::..|.|..
Mouse   793 FCPPLIYTNLIVFRKSE--------EEPTQKDLDFDMDSSINGAGPPGTVEPSAKVALERRQRRR 849

  Fly   814 AGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEF 878
            .|     :||....:|                                           |::.:|
Mouse   850 PG-----RALCCGKFS-------------------------------------------KRWSDF 866

  Fly   879 YTAPITKFWADSIAYMFFLIMFSFTVLVKME-QMPRWQEWYSIAYITTLGFEKVREIISS----- 937
            :.||:|.|..:.::|:.||::|:..:||..: ..|...|.....:..||..|::|:.:..
Mouse   867 WGAPVTAFLGNVVSYLLFLLLFAHVLLVDFQPTKPSVSELLLYFWAFTLLCEELRQGLGGGWGSL 931

  Fly   938 -------EPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDIGRVIYCVDSIYWYLR 995
                   :...:.|:..::..:.||.||..|:..|::|:..|......|:||.:.|:|.:.:.||
Mouse   932 ASGGRGPDRAPLRHRLHLYLSDTWNQCDLLALTCFLLGVGCRLTPGLFDLGRTVLCLDFMIFTLR 996

  Fly   996 ILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIAGS 1060
            :|:|..|||.|||.:.::.||:|::.:|:..|.|.|:::||:.:.||.|..:...|:::.|
Mouse   997 LLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLCVWLVAYGVATEGILRPQDRSLPSILRRV---- 1057

  Fly  1061 ITAPGFLGALGHNTRSSYHRGY---------HTMGA-PPVTTTAASTTTGSSSTVPAATTSTTAP 1115
                             ::|.|         ..|.| |....||.:|:||..|    ||.|:...
Mouse  1058 -----------------FYRPYLQIFGQIPQEEMDATPSAKCTATATSTGRHS----ATASSGNS 1101

  Fly  1116 I------HNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSM 1174
            |      |...|:|...:                             |..||.....|..:|
Mouse  1102 IRGLPWPHPSSSSLMCAS-----------------------------SSSGCAGVAGVAGLT--- 1134

  Fly  1175 YLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKY 1239
                                                            .|||
Mouse  1135 ------------------------------------------------CPPP------------- 1138

  Fly  1240 CVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETM 1304
               ::....|:.:.|  :.|.|:...:|..:|.      .|::..:|.|:.|:| .:.:||::..
Mouse  1139 ---QSSSTSVRLELG--VCLSKEAERKLLTWES------VHKENFLLAQARDKR-DSDSERLKRT 1191

  Fly  1305 SQKIEDINQKENIQTATVQNIEFRLRKMEESSE----------QILSHLAVI 1346
            |||::...:    |...::..:.|||.:|...:          :.|||.|::
Mouse  1192 SQKVDTALK----QLGQIREYDRRLRGLEREVQHCSRVLTWMAEALSHSALL 1239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	88/301 (29%)
		TRPV	<872..1227	CDD:454755	81/383 (21%)
		TRPM_tetra	1291..1346	CDD:465156	16/64 (25%)
Trpm4	XP_036009293.1	LSDAT_euk	184..441	CDD:476852	86/292 (29%)
		Ion_trans	<950..>1038	CDD:459842	31/87 (36%)