DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Trpm and Trpm7

DIOPT Version :10

Sequence 1:NP_001401007.1 Gene:Trpm / 36694 FlyBaseID:FBgn0265194 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_067425.2 Gene:Trpm7 / 58800 MGIID:1929996 Length:1863 Species:Mus musculus


Alignment Length:1775 Identity:617/1775 - (34%)
Similarity:905/1775 - (50%) Gaps:397/1775 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 RSWIETNFQKRECIKFIPCPKDD-------------TKCCCGQAQITHQTIPGIESGSPGDL--- 87
            :||||:...||||:..||..||.             .:|.||:....|.......:....|:   
Mouse     4 KSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDVKLG 68

  Fly    88 ---------WLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELP 143
                     |...|||...||||||.|.||||:|..:|:|||||:||:||:::||..|||.:|||
Mouse    69 EHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEIILQLLLKEWQMELP 133

  Fly   144 KLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGR 208
            ||:|:|.||...|:|..::|:.:.|||:|||.||||||.|||.||||.|.|||||.....:.:.:
Mouse   134 KLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRK 198

  Fly   209 VVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILR 273
            :.:|||||||::|..::|:|.:...|..::.:|.|||.||||.|::|:|||:||..|||||:.||
Mouse   199 ICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLR 263

  Fly   274 RKLEKFISNLKLHPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSG 338
            |:|||.|:..::|..         .....|||.|:.|||.|.|..||||:.:|||||||||:|:|
Mouse   264 RELEKTINQQRIHAR---------IGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTG 319

  Fly   339 RAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFR 403
            |||||||::||...:|...|  ::....:|.||:|||..|..::..|:|.:::|.:.|.|||||.
Mouse   320 RAADLLAYIHKQTEEGGNLP--DAAEPDIISTIKKTFNFGQSEAVHLFQTMMECMKKKELITVFH 382

  Fly   404 IQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMM 468
            |..:   :.|::|..|||||.|..:.|..:||.|.|.|:|||||::.:|||||:|..|:|::||:
Mouse   383 IGSE---DHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAML 444

  Fly   469 QALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPAN-TLGYILRDVRP-HIPKGYIYTL 531
            .||..||:.|||||:||||||.|||||||||||||||.||.| .|.:::|||:. ::|.||..||
Mouse   445 DALVMDRVSFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLIRDVKQGNLPPGYKITL 509

  Fly   532 HDIGLVINKLMGGAYRSYYTRRKFRPIY---------------------AKVMNSYANACRKSST 575
            .||||||..||||.||..|||::||.||                     .|...::.|...|...
Mouse   510 IDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHETFGNRADKKEK 574

  Fly   576 YQY-------QRYAGANSLSLVTGLLPFTS---------EMALFEFPFNELLIWAVLTKRQQMAL 624
            .::       |.|......|:..|....|.         |...|.:|.|||||||.|.|||.||.
Mouse   575 MRHNHFIKTAQPYRPKMDASMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMAR 639

  Fly   625 LMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEK 689
            .:|.||||::||:||:||:|::||:||.:.||..:..|||:.|:.:|.....:||:.|:|||...
Mouse   640 FLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETM 704

  Fly   690 AQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPF 754
            |.:|||.||.:|||.:||.|||::..|..:||.|:|::|:|:|||.|..|||:.:||||.:.:|.
Mouse   705 AMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPP 769

  Fly   755 YIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAESALLKAKRSISLRYRMGAGANNR 819
            .|..|::|:|.|:..:||:::.|    .:..:||:.:                        .:|.
Mouse   770 AILMLEYKTKAEMSHIPQSQDAH----QMTMEDSENN------------------------FHNI 806

  Fly   820 DKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQH---QPLRLKKKFYEFYTA 881
            .:.:..:.:.          :|.:.||...:          ||::.|   :.|.:.:|||.||.|
Mouse   807 TEEIPMEVFK----------EVKILDSSDGK----------NEMEIHIKSKKLPITRKFYAFYHA 851

  Fly   882 PITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKF 946
            ||.|||.:::||:.||::::|.|||||||:|..|||..||||.|...|||||:..||...|:.|.
Mouse   852 PIVKFWFNTLAYLGFLMLYTFVVLVKMEQLPSVQEWIVIAYIFTYAIEKVREVFMSEAGKISQKI 916

  Fly   947 SVWAWNMWNPCDGAAIILFVIGLAFRFRE-----NTMD-----IGRVIYCVDSIYWYLRILNILG 1001
            .||..:.:|..|..|||.|.:|...||..     |..|     .||:|||::.|:||:|:|:.|.
Mouse   917 KVWFSDYFNVSDTIAIISFFVGFGLRFGAKWNYINAYDNHVFVAGRLIYCLNIIFWYVRLLDFLA 981

  Fly  1002 VNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIAGSITAPGF 1066
            ||:..||.|.|:||||.||.|.||::|:||:||||.|:|||||:::|:|||.|:::         
Mouse   982 VNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEEPSWSLAKDIV--------- 1037

  Fly  1067 LGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGNLTNV 1131
                                                                             
Mouse  1038 ----------------------------------------------------------------- 1037

  Fly  1132 TFQPYFMLYGEVFAGDIDPPCGEDPSQPG-CVTGHWVTPITMSMYLLIANILLINLLIAVFNNIF 1195
             |.||:|::|||:|.:|| .|..|.:.|. |..|.|:||...::||.:..|:::|||||.|||::
Mouse  1038 -FHPYWMIFGEVYAYEID-VCANDSTLPTICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVY 1100

  Fly  1196 NEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDNGLKLFLE 1260
            .:|.::|:.||.:||:..:|.|.:|||||||.|.|.|..||. .||.|.:..:...| |.||||.
Mouse  1101 LQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLF-CCVCKRRKKDKTSD-GPKLFLT 1163

  Fly  1261 KDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNI 1325
            ::|.::|:||||:|||.:|.|::...|..::||::.|.||||.||.:|:::..:.|....::|::
Mouse  1164 EEDQKKLHDFEEQCVEMYFDEKDDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSL 1228

  Fly  1326 EFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRM-----RTISIS----- 1380
            :.::..:::     ||.|.|            |.|:..|.....|..::     |.:|||     
Mouse  1229 DSQIGHLQD-----LSALTV------------DTLKTLTAQKASEASKVHNEITRELSISKHLAQ 1276

  Fly  1381 ------------------DTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSL 1427
                              :|...|.|.|:                            |...|..|
Mouse  1277 NLIDDVPVRPLWKKPSAVNTLSSSLPQGD----------------------------RESNNPFL 1313

  Fly  1428 TEVRPDAYIFDE--------GTHFEVVP------LPE-------------EPDEVVKSREALNEQ 1465
            ..:    ::.||        |....|:|      :||             .|.|:.:.|..:...
Mouse  1314 CNI----FMKDEKDPQYNLFGQDLPVIPQRKEFNIPEAGSSCGALFPSAVSPPELRQRRHGVEML 1374

  Fly  1466 VV--RKASMQSEADSDIYIPVSQRPSTCETVKRTPYVTVRQDTGASTESKDTL---TPMGNNDDD 1525
            .:  :...:.|..:|.   |....|.|..:|......:.:....::|:.::.:   ...|:|.:.
Mouse  1375 KIFNKNQKLGSSPNSS---PHMSSPPTKFSVSTPSQPSCKSHLESTTKDQEPIFYKAAEGDNIEF 1436

  Fly  1526 QTLVGGDNSDDA-----------------TPDINFE---AARHRALRQRTVSLCRRNSETYSLTG 1570
            ...||..:|.|.                 ||:...:   ||.:.       ..|:.::..:|:  
Mouse  1437 GAFVGHRDSMDLQRFKETSNKIRELLSNDTPENTLKHVGAAGYS-------ECCKTSTSLHSV-- 1492

  Fly  1571 ADINRSHISLNQLASLSRRQMSLTQSEPDSDKDAPI--------------------AQGSAHPGK 1615
                       |..|.|||  :.|:..|:.|..|.:                    ..|.|.|.|
Mouse  1493 -----------QAESCSRR--ASTEDSPEVDSKAALLPDWLRDRPSNREMPSEGGTLNGLASPFK 1544

  Fly  1616 SVL-----HAKPSRNILLKL 1630
            .||     ::...||.|::|
Mouse  1545 PVLDTNYYYSAVERNNLMRL 1564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpmNP_001401007.1 LSDAT_euk 116..392 CDD:465665 135/275 (49%)
TRPV <872..1227 CDD:454755 141/365 (39%)
TRPM_tetra 1291..1346 CDD:465156 15/54 (28%)
Trpm7NP_067425.2 LSDAT_euk 106..371 CDD:465665 135/275 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 544..574 3/29 (10%)
TRPV <722..1172 CDD:454755 199/575 (35%)
TRPM_tetra 1194..1249 CDD:465156 18/71 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1380..1418 6/40 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1498..1539 7/42 (17%)
Alpha_kinase_ChaK1_TRMP7 1578..1816 CDD:341221
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1838..1863
Blue background indicates that the domain is not in the aligned region.

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