Protein Alignment Trpm and Trpm5

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_064673.2
• Gene: Trpm5 / 56843
• MGIID: 1861718
• Length: 1158
• Species: Mus musculus
• Alignment Length: 1322
• Identity: 348/1322 - (26%)
• Similarity: 570/1322 - (43%)
• Gaps: 301/1322 - (22%)

  Fly    70 QITHQTIPGIESGSPGDL---WLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLV 131
            |.|..:.|    |||.|.   |        :|....|.|.| ||:...:.::|::.....|.:|.
Mouse     2 QTTQSSCP----GSPPDTEDGW--------EPILCRGEINF-GGSGKKRGKFVKVPSSVAPSVLF 53

  Fly   132 QLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGD 196
            :|...||:|..|.|::::.|.:....:::.|:..:||||:|||::|||||.|...:.|:.:.||.
Mouse    54 ELLLTEWHLPAPNLVVSLVGEERPLAMKSWLRDVLRKGLVKAAQSTGAWILTSALHVGLARHVGQ 118

  Fly   197 ALLLEGQQRTG---RVVSIGIAPWGIVERNHELLG-HNRE-VPCH------SISSPRSKLAVLNN 250
            |:.......|.   |||:||:|....:.....|.| |.:| .|.|      :|..|   |..|::
Mouse   119 AVRDHSLASTSTKIRVVAIGMASLDRILHRQLLDGVHQKEDTPIHYPADEGNIQGP---LCPLDS 180

  Fly   251 RHAYFLLVDNGTQAKYGAELI-LRRKLEKFISNLKLHPSKNHWLKTNVTHSS---TPVVCLVIEG 311
            ..::|:||::|........|. |:..|||.||.          .:|....:|   .||:||::.|
Mouse   181 NLSHFILVESGALGSGNDGLTELQLSLEKHISQ----------QRTGYGGTSCIQIPVLCLLVNG 235

  Fly   312 GTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTI-QKTF 375
            ..||:..:...|..:  .|.::..|||..||:||             .|.|....|:..: :|.|
Mouse   236 DPNTLERISRAVEQA--APWLILAGSGGIADVLA-------------ALVSQPHLLVPQVAEKQF 285

  Fly   376 EVGLDQSEKL------------YQELLQ-CTRNKNLITVFRIQEKPEGEAQELDQTILTALFKS- 426
            .      ||.            :.|||| ...:.:|:||:..::  || :::||..||.||.|:
Mouse   286 R------EKFPSECFSWEAIVHWTELLQNIAAHPHLLTVYDFEQ--EG-SEDLDTVILKALVKAC 341

  Fly   427 -QHLSPP----EQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENG 486
             .|....    ::|.||:.|:|||||:||||....||.:..|:|.|..||..::.|||:|.:::|
Mouse   342 KSHSQEAQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMTDALVSNKPDFVRLFVDSG 406

  Fly   487 VSMKKFLTIPRLEELYNT-------------KH--GPANTLGYILRDVRPHIPKGY-IYTLHDIG 535
            ..|.:|||..||::||::             ||  |.....|...:..| .:|.|. .::||::.
Mouse   407 ADMAEFLTYGRLQQLYHSVSPKSLLFELLQRKHEEGRLTLAGLGAQQAR-ELPIGLPAFSLHEVS 470

  Fly   536 LVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEM 600
            .|:...:..|.|.:                |.:..|.......:|.||..       .||..|..
Mouse   471 RVLKDFLHDACRGF----------------YQDGRRMEERGPPKRPAGQK-------WLPDLSRK 512

  Fly   601 ALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELR 665
            :  |.|:.:|.:||||..|.:||...|..|.|.:|.:|.:||:.|.|:|...|    .|:...:|
Mouse   513 S--EDPWRDLFLWAVLQNRYEMATYFWAMGREGVAAALAACKIIKEMSHLEKE----AEVARTMR 571

  Fly   666 SYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILAD 730
            .  .::|.....|....|....::|..||....||||..:||.||..|:.:|..||...|..|..
Mouse   572 E--AKYEQLALDLFSECYGNSEDRAFALLVRRNHSWSRTTCLHLATEADAKAFFAHDGVQAFLTK 634

  Fly   731 LWMGGLRTRKNTNFKVILG-LAMP--FYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQ 792
            :|.|.:.|  .|....:|| ...|  .|...:.| |::..|:|               |..|..:
Mouse   635 IWWGDMAT--GTPILRLLGAFTCPALIYTNLISF-SEDAPQRM---------------DLEDLQE 681

  Fly   793 PDAESALLKAKRSISLRYRMGAGANNRDKALLADTYSVRDTKVHENGKV-SLTDSDTAQFREFFN 856
            ||            ||         :.:|:.|..          ..|:: .||::..|.    .:
Mouse   682 PD------------SL---------DMEKSFLCS----------RGGQLEKLTEAPRAP----GD 711

  Fly   857 LSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKME---QMPRWQEWY 918
            |..       |...|..::.:|:.||:|.|..:.:.|..||.:|::.:||...   |.|...|..
Mouse   712 LGP-------QAAFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGSEVT 769

  Fly   919 SIAYITTLGFEKVRE-IISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDIGR 982
            ...::.||..|::|: ..:.|...:..||:::..:.||.||..||.||::|:..|...:..:.||
Mouse   770 LYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVEDNWNKCDMVAIFLFIVGVTCRMVPSVFEAGR 834

  Fly   983 VIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQ 1047
            .:..:|.:.:.||:::|..::|.|||.:.::.:|:|::.:|:..|:|.|:::||:.||:|:|
Mouse   835 TVLAIDFMVFTLRLIHIFAIHKQLGPKIIIVERMMKDVFFFLFFLSVWLVAYGVTTQALLHP--- 896

  Fly  1048 PTWSLIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTST 1112
                                                                             
Mouse   897 ----------------------------------------------------------------- 896

  Fly  1113 TAPIHNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDIDPP---CGEDP----SQPGC--VTGHWVT 1168
                   |..........|.::||..::|::...:||..   |...|    |...|  :..:|:.
Mouse   897 -------HDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSLHPLLLESSASCPNLYANWLV 954

  Fly  1169 PITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHF 1233
            .:.:..:||:.|:||:|||||:|:..|..|...:...|.|||:.:::||..:|.|.||||.|.|.
Mouse   955 ILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYHLIVEYHGRPALAPPFILLSHL 1019

  Fly  1234 YSLLKYCVRKAKGLEVQRDNGLKLFLEKD-----DLERLYDFEEECVEGFFHEQEIILNQSTDER 1293
            ..:||...||    |.|..   :..||:|     | :::..:|....|.|....|.....|..|.
Mouse  1020 SLVLKQVFRK----EAQHK---RQHLERDLPDPLD-QKIITWETVQKENFLSTMEKRRRDSEGEV 1076

  Fly  1294 VKNTTERVETMSQKIEDINQKE 1315
            ::.|..||:.:::.|..:.::|
Mouse  1077 LRKTAHRVDLIAKYIGGLREQE 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	85/304 (28%)
		TRPV	<872..1227	CDD:454755	87/367 (24%)
		TRPM_tetra	1291..1346	CDD:465156	6/25 (24%)
Trpm5	NP_064673.2	LSDAT_euk	49..267	CDD:476852	71/232 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..507		4/25 (16%)
		TRPV	<711..1022	CDD:454755	95/392 (24%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:S5UH55	917..919		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1127..1158