Protein Alignment Trpm and trpm3

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_021332142.1
• Gene: trpm3 / 565807
• ZFINID: ZDB-GENE-060531-95
• Length: 1783
• Species: Danio rerio
• Alignment Length: 2014
• Identity: 729/2014 - (36%)
• Similarity: 1017/2014 - (50%)
• Gaps: 485/2014 - (24%)

  Fly    39 RSWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTI-PGIESG------------SPGDLWLP 90
            :||||..|.||||:..|...||..:||||:....|..: |.|.|.            |..:.|..
Zfish    62 KSWIERAFSKRECVHIIVSTKDHHRCCCGRLIGQHVGLPPSISSNQNEKSERVPKNDSLSEKWSI 126

  Fly    91 TKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKAN 155
            :|||:..||||:||||||||.|..||.|||:|:||:|:||:.|.||||.||||||||:|.||..|
Zfish   127 SKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSYDTKPDLLLHLMTKEWQLELPKLLISVHGGLQN 191

  Fly   156 FDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIV 220
            |:||.|||:...|||:|||.||||||||||.||||.:.|||||.....:..|::.:|||||||||
Zfish   192 FELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIV 256

  Fly   221 ERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKL 285
            |...:|:|.:...|..::|:|.|||.|||:.|::|:|.||||..|||||:.|||:|||.||..|:
Zfish   257 ENQEDLVGKDVVRPYQTMSNPLSKLTVLNSLHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKI 321

  Fly   286 HPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKY 350
            :        |.: ....|||.|::|||.|.|..||||:.|:||||||||||||||:|:|||.|||
Zfish   322 N--------TRI-GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKY 377

  Fly   351 ASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQEL 415
            :.:|  ..:.||:||.|:.||||||.....|::.|:..|::|.:.|.||||||:..  ||. |::
Zfish   378 SEEG--GIINESLRDQLLVTIQKTFTYSRTQAQHLFIILMECMKKKELITVFRMGS--EGH-QDI 437

  Fly   416 DQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVK 480
            |..|||||.|..:.|.|:||||||.|||||||||:||:|||:||.|:|:::|:.||..||:||||
Zfish   438 DLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQSMLDALVLDRVDFVK 502

  Fly   481 LLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDVRP-------------HIPKGYIYTLH 532
            ||:||||||.:|||:.||||||||:|||:|||.:::|||:.             ::|..|..:|.
Zfish   503 LLIENGVSMHRFLTLSRLEELYNTRHGPSNTLYHLVRDVKKQEYPGFSWIYLKGNLPPDYRISLI 567

  Fly   533 DIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFT 597
            ||||||..|||||||..|||::||.:|..:.........|                    ||...
Zfish   568 DIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALK--------------------LLGME 612

  Fly   598 SEMAL--------------------------FEFPFNELLIWAVLTKRQQMALLMWTHGEEALAK 636
            .:|.:                          |.|||:||::||||.|||:|||..|.|||||:||
Zfish   613 DDMPIRRGRQKTTRKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAK 677

  Fly   637 SLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSW 701
            :||:|||.|||||||:|:|:..:|.:||...::||.....:|||.||:||.:.|.:|||.||.:|
Zfish   678 ALVACKLCKAMAHEASENDMVDDISQELNQNSREFGQLAVELLDQSYKQDEQMAMKLLTYELKNW 742

  Fly   702 SNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEE 766
            ||.:||.|||||.||..:||.|||::|.|:|||.||.|||:..||||||.:|..|..|:||:|:|
Zfish   743 SNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGLLLPPSILSLEFKNKDE 807

  Fly   767 LQQMPQTEEEHLENQNLDNDDSDRSQPDAESALLKAKRSISLRYRMGAGANNRDKALLADTYSVR 831
            :..|||.::.:|:.:::|..:....:.:.|......:.....:|        ...|:|
Zfish   808 MSYMPQDQDTYLQEKDVDEPEKQAKEKEEEDMEFTVRSYCETQY--------NSVAML------- 857

  Fly   832 DTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFF 896
                   |.||...|...|..|..|        :|:.:.|.:|.||||.|||.|||..::||:.:
Zfish   858 -------GNVSSEASRKKQVEEVQN--------RHRLIPLGRKIYEFYNAPIVKFWFHTLAYVGY 907

  Fly   897 LIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAA 961
            |::|::.|||||:..|..|||..||||.|.|.||:|||:.|||..:..|..||....||..|..|
Zfish   908 LMLFNYIVLVKMDLWPSPQEWIVIAYIFTNGIEKMREILMSEPGKLLQKVKVWLQEYWNITDLMA 972

  Fly   962 IILFVIGLAFRFRE-NTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVV 1025
            |::|.||:..|.:: ..|..|||||||:.||||:|:|:|.||||||||.|.|:|||:.:|:|||:
Zfish   973 ILIFSIGMVLRLQDPPLMSYGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVI 1037

  Fly  1026 LLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPV 1090
            ::.||||||||:|||||.||:.|:|.|.:
Zfish  1038 IMLVVLMSFGVARQAILNPNEDPSWMLAR------------------------------------ 1066

  Fly  1091 TTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDID------ 1149
                                                   |:.|.||:|:||||||..||
Zfish  1067 ---------------------------------------NIFFMPYWMIYGEVFADQIDHVNSRK 1092

  Fly  1150 ------------------------------PPCGEDPSQ--------PGCVTGHWVTPITMSMYL 1176
                                          .|||::.:.        |.|.||.|:.|..|:.||
Zfish  1093 LHPKVNDKLWLVENYMRTQGTGRYSGPSHIAPCGQNITTEEGVVMPLPPCKTGAWIVPAIMACYL 1157

  Fly  1177 LIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKY-C 1240
            |:|||||:|||||||||.|.||.|:|:|||.|||:.::|.:.::||||||.|...|...:||: |
Zfish  1158 LVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHITMVLKHLC 1222

  Fly  1241 VRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMS 1305
            .|..|..|.:||.|||||:.:|:|::::||||:|:|.:|.|::...|.|.|||::.|:||||.|:
Zfish  1223 CRWRKHDEDERDYGLKLFITEDELKKVHDFEEQCMEEYFREKDDRFNSSNDERIRVTSERVENMA 1287

  Fly  1306 QKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAV-IHRFMSTHTAGADDLRGSTINIPG 1369
            .::|::|::|:...|::|.::.||.:|||    ::..:|| :.|     .||.|         .|
Zfish  1288 MRLEEVNEREHFMKASLQTVDIRLAQMEE----MIGRIAVALER-----VAGMD---------RG 1334

  Fly  1370 EMQRMRTISISD---------TEGGSGPGGNG---------GGGGGGGAIVPLGLGAGLNLNSLQ 1416
            |:.:.|:.:.||         ....:...||.         ||........|..|...:..:|..
Zfish  1335 EVNKARSRTSSDCTDTNYILRQSSFNSQEGNSYRLQESLEQGGDESISPTSPTALAPRVRSHSFY 1399

  Fly  1417 VTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSEAD---- 1477
            |:...:          |....|.|..|       ..|::.....|.:.|.|...:...|:.
Zfish  1400 VSHSSK----------DRSGADRGEGF-------FKDKLFSLHRANSSQSVSSGAGPKESKPTPL 1447

  Fly  1478 SDIYIPVSQRPSTC------------------ETVKRTPYVTVRQDTGASTESKDTLTPMGNNDD 1524
            :.:.:....|||:|                  ::|:..|  |:.:|:...:|..:.:. .|..|.
Zfish  1448 NTLSVQQQLRPSSCIDIYVSASEDVPPTESFLDSVRTVP--TLARDSSLHSEIMEAVL-SGGRDC 1509

  Fly  1525 DQTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRR 1589
            .....|.:...|.|  :.||.:....|     |||               .:|:
Zfish  1510 SGRAGGSERQSDGT--VLFEDSAAADL-----SLC---------------SAHL----------- 1541

  Fly  1590 QMSLTQSEPDSDKDAPIAQGSAHPGKSVL-HAKPSRNI------------LLKLHS--------- 1632
               |..|.|..|.|.     |..|...|| .:|.||.:            |:|.||
Zfish  1542 ---LPDSLPPWDLDP-----SPPPSAGVLERSKSSRFLSTAGPLFLDEPHLVKSHSLMFTSRGYY 1598

  Fly  1633 ----------EYTSITDELESVCHMIASP-----TVSLPSNKASLDRPKTEMSRAEAAALLEKKH 1682
                      |||||||.:::.|  :::|     ....|....:.|:|:
Zfish  1599 GGMGVQVKAAEYTSITDCIDTRC--VSTPYPVPERSDSPGGSFTFDKPQ---------------- 1645

  Fly  1683 LKECEENDYMILEGLIESRGSIDASAQGFEIGVSIDYSHRYPLRRETAVELSPSKPSVDGDLMGG 1747
                                         ::|||      :|   |...|||.::..::....|.
Zfish  1646 -----------------------------DLGVS------HP---ERDAELSHAESDLEEPAEGS 1672

  Fly  1748 GEGGGAGGGDSSDTSGAGSCGAMVGISSGFQLKNERPWQRNSSMEQQTYPSPLVP-TRATSDFLN 1811
            |:....|     .:|.:|..||.:|:  |..|              ..:.||:.. .||.|...:
Zfish  1673 GDTCKVG-----QSSSSGVIGADLGL--GLAL--------------GPFCSPISRLERANSCSSS 1716

  Fly  1812 PPYEGRLFKKSSESLQKNSSTETDYSAHPYRFIKQSSNETNTSLTGSYNVDTPSLT----AEPS 1871
            ......::.:.|.|:.:........|.:|::     ...|...|.|.    |.||:    |:||
Zfish  1717 EESHSNIYSRKSFSISERMDKGRGSSRNPFQ-----KARTGARLEGK----TDSLSMRKMAKPS 1771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	152/275 (55%)
		TRPV	<872..1227	CDD:454755	157/399 (39%)
		TRPM_tetra	1291..1346	CDD:465156	21/55 (38%)
trpm3	XP_021332142.1	LSDAT_euk	152..417	CDD:465665	152/275 (55%)
		TRPV	<893..1245	CDD:454755	167/426 (39%)
		TRPM_tetra	1273..1328	CDD:465156	22/63 (35%)