Protein Alignment Trpm and TRPM1

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_001238949.1
• Gene: TRPM1 / 4308
• HGNCID: 7146
• Length: 1642
• Species: Homo sapiens
• Alignment Length: 1900
• Identity: 677/1900 - (35%)
• Similarity: 967/1900 - (50%)
• Gaps: 423/1900 - (22%)

  Fly    39 RSWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSPG-------------DLWLP 90
            :||||..|.|||||..||..||..:||||  |.|:|.||.:.|.:|.             :.|..
Human    21 KSWIEKTFCKRECIFVIPSMKDSNRCCCG--QFTNQHIPPLPSATPSKNEEESKQVETQPEKWSV 83

  Fly    91 TKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKAN 155
            .|||:..|||:||.:|||||.:..||.|:|:|:||:|:.|:.|..|:|.||||||||:|.||..|
Human    84 AKHTQSYPTDSYGVLEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQN 148

  Fly   156 FDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIV 220
            |::|.|||:...|||:|||.||||||||||.:|||...|||||.....:..|||.:|||||||||
Human   149 FEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIV 213

  Fly   221 ERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKL 285
            |...:|:|.:......::|:|.|||:||||.|.:|:|.||||..|||||:.|||.|||.||..|:
Human   214 ENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKI 278

  Fly   286 HPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKY 350
            :....         ...|:|.||:|||.|.:..||||:.:.||:|||:|||||||:|:|:|.|||
Human   279 NTRLG---------QGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKY 334

  Fly   351 ASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQEL 415
            ..:|  ..:.||:|:.|:.||||||.....||.:|:..:::|.:.|.|:||||:..  ||: |::
Human   335 CEEG--GIINESLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGS--EGQ-QDI 394

  Fly   416 DQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPN-------------------- 460
            :..|||||.|..::|.|:||||||.|||||||||:|||:|..||.
Human   395 EMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPTDSKATEKEKKPP 459

  Fly   461 --------------------------------------GALDEAMMQALEHDRIDFVKLLLENGV 487
                                                  .||::||:.||..||:||||||:||||
Human   460 MATTKGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLLIENGV 524

  Fly   488 SMKKFLTIPRLEELYNTKHGPANTLGYILRDV-RPHIPKGYIYTLHDIGLVINKLMGGAYRSYYT 551
            :|:.|||||||||||||:.||.|||..::||| :.::|..|..:|.|||||:..|||||||..||
Human   525 NMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYT 589

  Fly   552 RRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSE----------------- 599
            |:.||.:|             ::.:..:|......|.:.....|...:
Human   590 RKNFRTLY-------------NNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDD 641

  Fly   600 --MALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYE 662
              ::.|::||:||::||||.|||:||:.:|..|||::||:||:||||||||||::|.||..:|.:
Human   642 PAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLVDDISQ 706

  Fly   663 ELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVI 727
            :|.:.:|:|.....:|||.||:.|.:.|.:|||.||.:|||.:||.|||||.||..:||.|||::
Human   707 DLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQML 771

  Fly   728 LADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQ 792
            |.|:|||.||.|||...|||:|:.:|..|..|:|::.::...  ||.:|     |.|..:.:...
Human   772 LTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSY--QTSKE-----NEDGKEKEEEN 829

  Fly   793 PDAESALLKAKRSISLRYRMGAGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNL 857
            .||.:               .||:...|
Human   830 TDANA---------------DAGSRKGD------------------------------------- 842

  Fly   858 SEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAY 922
             |.||.|:.:.:.:..|..|||.|||.|||..:|:|:.:|::|::.:||:|:..|..|||..|:|
Human   843 -EENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVISY 906

  Fly   923 ITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENT-MDIGRVIYC 986
            |.:|..||:|||:.|||..::.|..||....||..|..||..|:||...|.:... |..||||||
Human   907 IVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRVIYC 971

  Fly   987 VDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWS 1051
            ||.|:||:|:|:|.||||||||.|.|:|||:.:|:||||::.||||||||:|||||:|.::|:|.
Human   972 VDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWK 1036

  Fly  1052 LIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPI 1116
            |.:
Human  1037 LAR-------------------------------------------------------------- 1039

  Fly  1117 HNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDID-------PPCGED------PSQPGCVTGHWVT 1168
                         |:.:.||:|:||||||..||       |||||:      ...|.|:.|.|:|
Human  1040 -------------NIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLT 1091

  Fly  1169 PITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHF 1233
            |..|:.|||:|||||:|||||||||.|.||.|:|:|||.|||:.::|.:..:||||||.|.|.|.
Human  1092 PALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHI 1156

  Fly  1234 YSLLK----YCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERV 1294
            |.::.    .|.:|.:|.:.:||.||||||..::|:||::|||:||:..|.|:|.....|:|||:
Human  1157 YIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERI 1221

  Fly  1295 KNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGAD- 1358
            :.|:||||.||.::|:||::|.....::|.::.||.::||.|.::::.|        .:.||.|
Human  1222 RVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNAL--------ENLAGIDR 1278

  Fly  1359 -DLRGSTINIPGEMQR---MRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTT 1419
             ||..:......|.:.   :|..||:..:|.|                               ..
Human  1279 SDLIQARSRASSECEATYLLRQSSINSADGYS-------------------------------LY 1312

  Fly  1420 RRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREA---LNEQVVRKASMQSEADSDIY 1481
            |..||             .|...||...|...|...|:.:..   :.|:...|..:..|..:.::
Human  1313 RYHFN-------------GEELLFEDTSLSTSPGTGVRKKTCSFRIKEEKDVKTHLVPECQNSLH 1364

  Fly  1482 IPVSQRPS--------------TCETVKRTPYVTV-RQDTGASTESK--DTLTPMGNNDDDQTLV 1529
            :.:....|              ..|..|..|.:.: ::|....|:||  :|::|..|..|  .:.
Human  1365 LSLGTSTSATPDGSHLAVDDLKNAEESKLGPDIGISKEDDERQTDSKKEETISPSLNKTD--VIH 1427

  Fly  1530 GGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMSLT 1594
            |.|.||...             .|.||       ||.::.|.            .|....:..:|
Human  1428 GQDKSDVQN-------------TQLTV-------ETTNIEGT------------ISYPLEETKIT 1460

  Fly  1595 QSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNIL--LKLHSEYTSITDE---LESVCHMIASPTVS 1654
            :..||...:|.....|    :|.:::: .|.::  :....||:||||:   .|..|.      |.
Human  1461 RYFPDETINACKTMKS----RSFVYSR-GRKLVGGVNQDVEYSSITDQQLTTEWQCQ------VQ 1514

  Fly  1655 LPSNKASLDRPKTEMSRAEAAALLEKKHLKECEENDYMILEGL--IESRGSIDASAQGFE--IGV 1715
            ..:...|.|.|...   :|||...|.|......::::.:.|.:  |...........|.|  :.|
Human  1515 KITRSHSTDIPYIV---SEAAVQAEHKEQFADMQDEHHVAEAIPRIPRLSLTITDRNGMENLLSV 1576

  Fly  1716 SIDYSHRYPLRRETAVELSP-SKPSVDGDLMGGGEGGGAGGGDSSDTSGAGSCGAMVGISSGFQL 1779
            ..|.:..:|..|..::...| :..|:.|.|               |.||..|..:.:.|.||...
Human  1577 KPDQTLGFPSLRSKSLHGHPRNVKSIQGKL---------------DRSGHASSVSSLVIVSGMTA 1626

  Fly  1780 KNERPWQRNSSMEQQ 1794
            :.::..:..:|.|.:
Human  1627 EEKKVKKEKASTETE 1641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	141/275 (51%)
		TRPV	<872..1227	CDD:454755	153/368 (42%)
		TRPM_tetra	1291..1346	CDD:465156	21/54 (39%)
TRPM1	NP_001238949.1	LSDAT_euk	109..374	CDD:465665	141/275 (51%)
		TRPV	<751..1149	CDD:454755	197/532 (37%)
		TRPM_tetra	1218..1273	CDD:465156	21/62 (34%)