Protein Alignment Trpm and Trpm6

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_700466.1
• Gene: Trpm6 / 225997
• MGIID: 2675603
• Length: 2028
• Species: Mus musculus
• Alignment Length: 2151
• Identity: 665/2151 - (30%)
• Similarity: 1000/2151 - (46%)
• Gaps: 497/2151 - (23%)

  Fly    39 RSWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIP-------------------GIESGSP 84
            :||||..|.||||.||||..||..:|..| .||.|..:.                   .:..|..
Mouse     5 KSWIEGVFYKRECNKFIPSSKDPHRCTPG-CQICHNLVRCYCGRLIEEHHGLDRAWNLSVTEGHG 68

  Fly    85 GDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITV 149
            .:.|...|||...|||.:|||.||.|.|...::|:|.|:||:.:.|:.|..||||:|||||:|:|
Mouse    69 DEQWSVEKHTVKSPTDTFGTINFQDGEHIHHSKYIRTSWDTKSDHLLHLMLKEWNMELPKLVISV 133

  Fly   150 QGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGI 214
            .||..||.:.:|||:...:||:|||:||||||.|.|.|:||:|.|||||.....:...::.::||
Mouse   134 HGGLQNFKISSKLKETFSQGLVKAAETTGAWIITEGINSGVSKHVGDALKAHSSKSLRKIWTVGI 198

  Fly   215 APWGIVERNHELLGHNREVPC--HSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLE 277
            .|||::|...||:|  ::|.|  .::.:|.|||..||..|::|:|.|:||...||.|..|||.||
Mouse   199 PPWGVIENQRELVG--KDVVCMYQTLGNPLSKLTTLNCMHSHFILCDDGTVGMYGNEEKLRRNLE 261

  Fly   278 KFISNLKLHPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAAD 342
            |.:|..|:|         ..:....|||.||:|||.|.|..|.|.|.:..  |||||:|:|||||
Mouse   262 KHLSMQKIH---------TCSRQGVPVVGLVMEGGPNVILWVWETVKNKE--PVVVCEGTGRAAD 315

  Fly   343 LLAFVHKYASDGEEQPVLE-SMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQE 406
            ||||.:|:..||   .:|. .:::.|...||..|...|.||:.|:|.|::|..:|:.||:|   :
Mouse   316 LLAFTYKHLEDG---GILRPQVKEELFCLIQNMFNFSLRQSKHLFQILMECMVHKDSITIF---D 374

  Fly   407 KPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQAL 471
            ....|.|:||..|||||.|...||..|||:||:.|:|:|||:..|..|||.|..|||::||:.||
Mouse   375 ADSEEHQDLDLAILTALLKGTSLSISEQLNLAMAWDRMDIAKKHILTYGQHWKPGALEQAMLDAL 439

  Fly   472 EHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANT-LGYILRDVRPH-IPKGYIYTLHDI 534
            ..||:||||||:||||::.:||||||||||||||.||.|. |.::::||:.| :...|..||.||
Mouse   440 VMDRVDFVKLLIENGVNLHRFLTIPRLEELYNTKQGPTNKFLRHLVQDVKQHTLLSSYRITLIDI 504

  Fly   535 GLVINKLMGGAYRSYYTRRKFRPIY------AKVMNSYANACRKSSTYQYQRYAGANSLSLVTGL 593
            ||||..|:||||||.|||:.||.:|      .|.::|:|....:.|.  :||::..|........
Mouse   505 GLVIEYLIGGAYRSSYTRKSFRILYNNLYRKHKSVSSFAQGLSQHSL--HQRHSLRNRKESSEST 567

  Fly   594 L---------PFTS------------------------EMALFEFPFNELLIWAVLTKRQQMALL 625
            |         |:.|                        |.|.|.:|:|:||:||||.|||.||:.
Mouse   568 LHSQFFRTAQPYKSKEKPEDSQKSKKKSKERQSLSEEPEAAGFIYPYNDLLVWAVLMKRQNMAMF 632

  Fly   626 MWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKA 690
            .|.|||||..|::::..||:|||.||.|.::..:..|||::|:::|......:|:.:::|:...|
Mouse   633 FWQHGEEATVKAVIASILYRAMAREAKESNMVDDTSEELKNYSEQFGQLALDVLEKAFKQNEPMA 697

  Fly   691 QRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFY 755
            .:|||.||.:|||.:||.|||:...|..::|.|:|::|.|:|||.|:.|||:..|:|:.:.:|..
Mouse   698 MKLLTYELKNWSNSTCLKLAVSGGLRPFVSHSCTQMLLTDMWMGRLKMRKNSWLKIIISILLPPM 762

  Fly   756 IRQLDFKSKEELQQMPQTEE----EHLENQNLDNDDSDRSQPDAESALLKAKRSISLRYRMGAGA 816
            |..|:||||.|:..:||:::    .:..:|.|.|        ..|||.:|       .|.:..|.
Mouse   763 ILTLEFKSKAEMSHVPQSQDFQFTWNYSDQGLSN--------TKESACVK-------DYDLERGP 812

  Fly   817 NNR-DKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYT 880
            :.: |:.|..|..:|                                   .|.|...::.||||:
Mouse   813 DEKPDEPLHLDLRNV-----------------------------------PQSLPWTRRVYEFYS 842

  Fly   881 APITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHK 945
            ||..|||..::||:.||::|::||||:|:..|...||..|.||.|...||||||..|||.....|
Mouse   843 APFVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVHEWLVIIYIFTNAIEKVREICISEPSKFKQK 907

  Fly   946 FSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMD-IGRVIYCVDSIYWYLRILNILGVNKYLGPL 1009
            ..:|....||..:..||.||.:|...|:....:. .||:|||:|.|:|:.|:::...||::.||.
Mouse   908 VKMWLSEYWNLMETVAIGLFAVGFGLRWGHPPLQTAGRLIYCIDIIFWFSRLMDFFAVNQHAGPY 972

  Fly  1010 VTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIAGSITAPGFLGALGHNT 1074
            |||:.||..||.|.|:::|:||:||||:|:|||.|.:.|:|.|.::::
Mouse   973 VTMIAKMAANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWRLARDIV----------------- 1020

  Fly  1075 RSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGNLTNVTFQPYFML 1139
                                                                      |:||:|:
Mouse  1021 ----------------------------------------------------------FEPYWMM 1027

  Fly  1140 YGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQ 1204
            ||||:|.||| .|..:.|   |..|.::||...::||.:..|:::|||||.||||:.::.|:|::
Mouse  1028 YGEVYASDID-VCSNETS---CPPGSFLTPFLQAVYLFVQYIIMVNLLIACFNNIYLDIKSISNK 1088

  Fly  1205 VWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLK-YCVRKAKGLEVQRDNGLKLFLEKDDLERLY 1268
            :|.:.|:..:|.|.|||.||||||.|.|...||: .|.|.|...:.:.|.||||:|.||||::|:
Mouse  1089 LWKYNRYRYIMTYHQKPWLPPPFILLNHLCLLLRGLCCRPAPQDQEEGDGGLKLYLTKDDLKKLH 1153

  Fly  1269 DFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKME 1333
            ||||:|||.:|||:...||.|.:|:::.|:|||..|..:::::|:|       |..|:..|..::
Mouse  1154 DFEEQCVEKYFHEKTEGLNCSFEEQIRMTSERVSEMFFQLKEMNEK-------VSFIKDSLLSLD 1211

  Fly  1334 ESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTISISDTEGGSGPGGNGGGGGGG 1398
            ..    :.||              .||...|::      .::.:|..||
Mouse  1212 SQ----VGHL--------------QDLSAITVD------TLKVLSAVDT---------------- 1236

  Fly  1399 GAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREALN 1463
                       |..:.:.:..|:   .|....||.::.       .|:..     :|:...|:..
Mouse  1237 -----------LQEDEILLANRK---HSTCRKRPHSWT-------NVICA-----KVLSDMESCG 1275

  Fly  1464 EQVVRKASMQSEADSDIYIPVSQRPSTCETVKRT---PYVTVRQDTGASTESKDTLTPMGNNDDD 1525
            ::.::..||.              ||...::.|:   |.|    ..||..|...:.....:..::
Mouse  1276 KKKLQYYSMP--------------PSLLRSLARSQLPPSV----QRGALVEVTHSKREASHVREE 1322

  Fly  1526 QTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLTG-ADINRSHISLNQLASLSRR 1589
            |                    ..|.:.|||.:           :| :.:.::|....|...:
Mouse  1323 Q--------------------EEREMEQRTTA-----------SGISHVRQAHSKYGQFLLV--- 1353

  Fly  1590 QMSLTQSEPDSDKDAPIA-QGSAHPGKSVLHAKPSRNILLKLHSE--YTSITDELESVCHMIASP 1651
                    |.|.|..|:: :...|..:|...|.....:|..:|..  .|.:..:..:..|.
Mouse  1354 --------PSSGKQVPLSLETPPHLFRSSEEAGIDGLVLEHIHQSDLTTHLPQQTPAASHQ---- 1406

  Fly  1652 TVSLPSNKASLDRPKTEMSRAEAAALLEKKHLKECEENDYMILEGL--------IESR------- 1701
              :|.:.........|:||...|.|           |.|.:...|.        :.||
Mouse  1407 --ALVAEHKDQHEAVTQMSDKPAKA-----------EQDLLAFSGTPAPMTVTSLPSRAISMQDE 1458

  Fly  1702 -GSID-ASAQGFEIGVSIDYSHRYPLRRETAVEL-----SPSKPSVDGDLMGGGEGGGAGGGDSS 1759
             |.:: |.::..|.||       :..:::....|     |.|.|..|..|..||..|       .
Mouse  1459 GGYVNWAFSENDETGV-------FSFKKKWKTCLASTCNSDSNPGGDYFLHTGGRSG-------L 1509

  Fly  1760 DTSG--AGSCGAMVGISSGFQLKNERPWQRNSSMEQQTYPSPLVPTRATSDFLNPPYEGRLFKKS 1822
            |.|.  |.||....|           ||   :...:..:.:||...:|    |...:..|..|:.
Mouse  1510 DNSRRLAQSCECPAG-----------PW---TQARRSFWINPLCRDKA----LIKSHSFRFHKEE 1556

  Fly  1823 -----------SESLQKNSS-------TETDYSAHPYRFIKQSSNETN------TSLTGSYNVDT 1863
                       |:||:..|:       |:|       |.:.:...:|.      .::...|..|
Mouse  1557 KLRKTWKNNSHSKSLETRSTWLKAKLLTKT-------RSLSKKKRKTQGLQVPVITVNACYQSD- 1613

  Fly  1864 PSLTAEP-SLDAGDSHSATGISISVGAVGGTATARYQ-----PIRTASVGAADGRRLREESSSSL 1922
             .|.||| ..:..:..|...:|:|..:..|.....||     .|:..:..|:|..|..:|:....
Mouse  1614 -QLNAEPGETNTTEEFSKKWLSVSNFSQIGLEPYIYQKMKMKEIKRHTTQASDHLRQPQENRDKT 1677

  Fly  1923 DLSSSGPVTMQAAPAPPVRPMLLKKQFSVDQGKPSQTAAEAVPQTPE-----AAQAGQAKLISTL 1982
            ...:||..::.       |..|.:....|.:...|..:    ||.|.     ..:....:|..|:
Mouse  1678 PTWNSGSTSLS-------RSFLTRSPNEVHKISTSLKS----PQEPHHHYSAIERNNLMRLSQTI 1731

  Fly  1983 KPQPFASKLGMNV----LKESSSST-DESVGSSAKSSNPALSIPQISTHLVQDEIAKLSSNIKSS 2042
            ...|.....|..|    |:|||..| |:|:.|.::....|: |..:|...:...:.|....|  |
Mouse  1732 PFTPIQLFTGEEVTIYKLEESSPLTLDKSMSSWSQHGRAAM-IQVLSQEEMDGGLRKAMRVI--S 1793

  Fly  2043 TESEKD 2048
            |.||.|
Mouse  1794 TWSEDD 1799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	124/278 (45%)
		TRPV	<872..1227	CDD:454755	124/355 (35%)
		TRPM_tetra	1291..1346	CDD:465156	13/54 (24%)
Trpm6	NP_700466.1	LSDAT_euk	100..363	CDD:465665	124/278 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..601		2/23 (9%)
		TRPV	<661..1111	CDD:454755	185/578 (32%)
		TRPM_tetra	1176..1231	CDD:465156	16/85 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1313..1339		6/56 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1658..1694		8/42 (19%)
		Alpha_kinase_ChaK2_TRPM6	1742..1980	CDD:341222	19/61 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2009..2028