Protein Alignment Trpm and gtl-2

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_502118.4
• Gene: gtl-2 / 178036
• WormBaseID: WBGene00001796
• Length: 1406
• Species: Caenorhabditis elegans
• Alignment Length: 1555
• Identity: 515/1555 - (33%)
• Similarity: 788/1555 - (50%)
• Gaps: 269/1555 - (17%)

  Fly    29 INITVPRHQPRSWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSPGDL------ 87
            |.:|.....|  |||..|:|||||:|...|||..:|.||:....|.......|..|..|
 Worm    78 IELTEKLSPP--WIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQ 140

  Fly    88 -WLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQG 151
             |....:|:...|||:|||.||||||..||||||||:|:.|..::.|..|.|.||.|:|:|||.|
 Worm   141 TWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHG 205

  Fly   152 GKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEG--QQRTGRVVSIGI 214
            |.:||:|:.:|.:..|||:||||:||||||.|.|.::||.:.|..||...|  .:...::|:|||
 Worm   206 GMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGI 270

  Fly   215 APWGIVERNHELLGHNREV--PCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLE 277
            ||||:::|...|:..|..|  ..||: |..:.:.:||:||:||||.||||..::||:|.||:.||
 Worm   271 APWGVIKRKERLIRQNEHVYYDVHSL-SVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLE 334

  Fly   278 KFISNLKLHPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAAD 342
            ..|:....:..|            .||||.::|||.::|.|:.:|||..|.:|.:||||||||||
 Worm   335 NHIATFGCNGRK------------VPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAAD 387

  Fly   343 LLAFVHKYA-SDGE-EQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQ 405
            :::|..:|. |||. ...|.|.:|:.:.....:|     || |::::::.:|....:|:.:||..
 Worm   388 IISFAARYINSDGTFAAEVGEKLRNLIKMVFPET-----DQ-EEMFRKITECVIRDDLLRIFRYG 446

  Fly   406 EKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQA 470
            ::   |.:::|..||:.:.:.|:|.|.|||:|.|:|||||:|:|.:|..|::|.:..|::||..|
 Worm   447 QE---EEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDA 508

  Fly   471 LEHDRIDFVKLLLENGVSMKKFLTIPRLEELY-----NTKHGPANTLGYILRDVRPHIPKGYIYT 530
            |..||:|||:.|||||||||.||:|.|||.||     |:.|...|.:.. ...:.||.   |: |
 Worm   509 LYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAHSVRNWMEN-FDSMDPHT---YL-T 568

  Fly   531 LHDIGLVINKLMGGAYRSYYTRRKFRPIY--AKVMNSYANACRKSSTYQYQRYAGANSLSLVTGL 593
            :..||.|:.||||.|::.|||.|.|:..|  .|.:|..:...||....|.:.:...:...:...
 Worm   569 IPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDN- 632

  Fly   594 LPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDT 658
               ..|...|.:|||:||||||||.|..||..||.|||:|:||.|::.:||||.|..|.::.||.
 Worm   633 ---EEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDV 694

  Fly   659 EIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPC 723
            |..:.|...|.:......:|||..||.|.::..|||..||..|.|.:||||||.||.:..|||||
 Worm   695 EEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPC 759

  Fly   724 SQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDS 788
            .|::||:||.|.|:.|..:|.:|:..|..|..|..:.:|.|            |.:...|.::::
 Worm   760 CQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPK------------HSKTARLLSEET 812

  Fly   789 DRSQPDAESALLKAKRSISLRYRMGAGANNRDKALL-ADTYSVRDTKV---HENGKVSLTDSDTA 849
            ....|....::..   :.|.|||...|...:.:.|| ..:|:.:.|.:   ..:|..|:..|.::
 Worm   813 PEQLPYPRESITS---TTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNSGVASVYGSASS 874

  Fly   850 QFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRW 914
            ..           .|:...|...::|..||::||||||:..||::.||...:..:|::....|..
 Worm   875 MM-----------FKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSK 928

  Fly   915 QEWYSIAYITTLGFEKVREIISSEPVAITHKFSV----WAWNMWNPCDGAAIILFVIGLAFR--- 972
            .||.:..|..||..|.:|::::||...|..|..|    | :|:|.   .||::.|::|..||
 Worm   929 YEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKW-YNIWT---SAALLFFLVGYGFRLVP 989

  Fly   973 -FRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGV 1036
             :|.:.   |||:....::.:|::|...|.|:..|||.:.|..|||.:|.|..|||.|.||:|||
 Worm   990 MYRHSW---GRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGV 1051

  Fly  1037 SRQAILYPN-KQPTWSLIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTG 1100
            :|||:..|| |...|.|::
 Worm  1052 NRQALTEPNVKDWHWLLVR---------------------------------------------- 1070

  Fly  1101 SSSTVPAATTSTTAPIHNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDIDPPCGEDPSQPGCVTGH 1165
                                         |:.::|||||||||:||:|| .||::..:  |..|:
 Worm  1071 -----------------------------NIFYKPYFMLYGEVYAGEID-TCGDEGIR--CFPGY 1103

  Fly  1166 WVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIAL 1230
            ::.|:.|.::||:|||||:|||||:||||:|:....|.::|:|||:..:|||...|.|||||...
 Worm  1104 FIPPLLMVIFLLVANILLLNLLIAIFNNIYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIF 1168

  Fly  1231 CHFYSLLKYC--VRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDER 1293
            .|.|..:.|.  :|:......:.::.:||.:.:|:::|:.||||:|::.....:::.||  |.|.
 Worm  1169 AHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLN--TKEP 1231

  Fly  1294 VKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSE---QILSHLAVIHRFMSTHTA 1355
            : :.|:..|...|::.|:.|:..:..:.|.:||.::..:..||:   |||.:..:...|    .|
 Worm  1232 L-SVTDLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNF----AA 1291

  Fly  1356 GADDLRGSTINIPGEMQ-----RMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSL 1415
            .:..|..::|.:|...:     .:..:||.|......|                     |..|..
 Worm  1292 SSLSLPDTSIEVPKITKTLIDCHLSPVSIEDRLATRSP---------------------LLANLQ 1335

  Fly  1416 QVTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSEADSDI 1480
            :..|.|:::        ||. |..|                        ::.|:|.:.|.:.|
 Worm  1336 RDHTLRKYD--------DAN-FQPG------------------------KLQRRARLHSSSCS-- 1365

  Fly  1481 YIPVSQRPSTCETVKRTPYVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPD 1540
               :||.....:|...:..:. |:|:|..|.|..               ||.:||.:.||
 Worm  1366 ---ISQDMKEMKTSMSSRNLK-REDSGEITTSSH---------------GGYDSDVSGPD 1406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	118/281 (42%)
		TRPV	<872..1227	CDD:454755	119/363 (33%)
		TRPM_tetra	1291..1346	CDD:465156	14/57 (25%)
gtl-2	NP_502118.4	LSDAT_euk	170..433	CDD:465665	118/281 (42%)
		Ion_trans	899..1123	CDD:459842	91/308 (30%)