Protein Alignment Trpm and gtl-1

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_502111.3
• Gene: gtl-1 / 178031
• WormBaseID: WBGene00001795
• Length: 1694
• Species: Caenorhabditis elegans
• Alignment Length: 1799
• Identity: 547/1799 - (30%)
• Similarity: 846/1799 - (47%)
• Gaps: 407/1799 - (22%)

  Fly     3 KQKRLAKQKPKAKPIPWGLKKICW--------------GLINITVPRHQPR-------SWIETNF 46
            ||:..:..|......|..::|..|              |....:...|..|       :|||...
 Worm    46 KQRSTSSDKAPLNSAPRHVQKFDWKDMLHLADISGRKRGNSTTSHSGHATRAGSLKGKNWIECRL 110

  Fly    47 QKRECIKFIPCPKDDTKCCCGQAQ-----------------ITHQTIPGIESGSPGDL------- 87
            :.|:|..|:|..:...:|.||:.:                 :.|.|:|||......|.
 Worm   111 KMRQCSYFVPSQRFSERCGCGKERSKHTEEVLERSQNKNHPLNHLTLPGIHEVDTTDADADDNEV 175

  Fly    88 ------WLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLL 146
                  |....||...||||||.|.|:|.||  .|||.|:|||:.|..:|.|..|.|.|:.|||:
 Worm   176 NLTPGRWSIQSHTEIVPTDAYGNIVFEGTAH--HAQYARISFDSDPRDIVHLMMKVWKLKPPKLI 238

  Fly   147 ITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRT-GRVV 210
            ||:.||...||||.||.:..|||::|.||:|.|||.|.|.:.||.|.:..||...|...: ..||
 Worm   239 ITINGGLTKFDLQPKLARTFRKGIMKIAKSTDAWIITSGLDEGVVKHLDSALHDHGNHTSKNHVV 303

  Fly   211 SIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRK 275
            :||||.||::::....:|.:..|...:.....::|..||:.|:|||..||||..:||||:|:|::
 Worm   304 AIGIASWGMLKQRSRFVGKDSTVTYATNVFNNTRLKELNDNHSYFLFSDNGTVNRYGAEIIMRKR 368

  Fly   276 LEKFISNLKLHPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRA 340
            ||.:::            :.:...|:.|:||:|:|||..||:.|.:|||..|.:||:||||||||
 Worm   369 LEAYLA------------QGDKKRSAIPLVCVVLEGGAFTIKMVHDYVTTIPRIPVIVCDGSGRA 421

  Fly   341 ADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQ 405
            ||:|||.|:..|  :...:.:::|:.|:..:::.|......::||.:::::|:.||:|:|:||:
 Worm   422 ADILAFAHQAVS--QNGFLSDNIRNQLVNIVRRIFGYDPKTAQKLIKQIVECSTNKSLMTIFRL- 483

  Fly   406 EKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQA 470
              .|...::||..|::.|.|.|:|||||||.|||.|||.||||:|||..|.||....|..||::|
 Worm   484 --GESSREDLDHVIMSCLLKGQNLSPPEQLQLALAWNRADIARTEIFANGTEWTTQDLHNAMIEA 546

  Fly   471 LEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTL-GYILRDVRPHIPKGYIYTLHDI 534
            |.:||||||.|||||||||:||||..|||.||||..||.||| ..:|.|.:.||      .|.::
 Worm   547 LSNDRIDFVHLLLENGVSMQKFLTYGRLEHLYNTDKGPQNTLRTNLLVDSKHHI------KLVEV 605

  Fly   535 GLVINKLMGGAYRSYYTRRKF---------RPIYAKVMNSYANACR-------------KSSTYQ 577
            |.::..|||..|:|.||:.:|         |..:.|.::|.:|..|             :.|:.|
 Worm   606 GRLVENLMGNLYKSNYTKEEFKNQYFLFNNRKQFGKRVHSNSNGGRNDVIGPSGDAGRERMSSMQ 670

  Fly   578 YQRYAGANS--LSLVTG--------------------LLPFTSEMALFEFPFNELLIWAVLTKRQ 620
            ......|.:  :||..|                    .:.||     |.:|:::|:|||||||||
 Worm   671 ISLINNARNSIISLFNGGGRKRESDDEDDFSNLEEEANMDFT-----FRYPYSDLMIWAVLTKRQ 730

  Fly   621 QMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQ 685
            :||.||||||||.:||:||:.:||.::|..|:....:..:.::...::.||.....::|::..:.
 Worm   731 KMAKLMWTHGEEGMAKALVASRLYVSLAKTASLATGEIGMSQDFTEFSDEFSELAVEVLEYCTKH 795

  Fly   686 DAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGL 750
            ..::..|||||||.:|.:::|||||....||..|||||.|::|:|||.|||..:.|.|.||:..|
 Worm   796 GRDQTLRLLTCELANWGDETCLSLAANNGHRKFLAHPCCQMLLSDLWQGGLLMKNNQNSKVLTCL 860

  Fly   751 AMPFYIRQLDFKSKEELQQMPQTEEEHLE-----------------NQNLDNDDSDR-------- 790
            |.|..|..|.||:||:|...|:|..||.|                 :.:.|:||||.
 Worm   861 AAPPLIFLLGFKTKEQLMLQPKTAAEHDEEMSDSEMNSAEDTDTSSDSSSDSDDSDEEDAKLRAQ 925

  Fly   791 ----SQPDAESALLKAKRSISLRYRMGAG------------ANNRDKALLADTYSVRDTK----- 834
                .||.:...|::.|.:.|.:.:...|            ..||     |.|.|::.:|
 Worm   926 SLSADQPLSIHRLVRDKLNFSEKKKPDMGISRIVVAPPIVTGRNR-----ARTMSIKKSKKNVIK 985

  Fly   835 ------------------------VHENGK-----VSLT------------DSDTAQ--FREFFN 856
                                    ::..||     |::.            |:.|.|  .|||.:
 Worm   986 PPACLKIETSDDDEQEQKKATEMYINRTGKRGSVAVAMNHDDMYIDPSEELDTQTRQKSSREFSS 1050

  Fly   857 LSEYN-EVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSI 920
            ..... :|...:||..|||..|||.||||.:|....|:::|||:.::.:|||.:::..|.|||..
 Worm  1051 SRNVTVQVYTQRPLSWKKKIMEFYKAPITTYWLWFFAFIWFLILLTYNLLVKTQRIASWSEWYVF 1115

  Fly   921 AYITTLGFEKVREIIS------SEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMD 979
            |||.....|..|:::|      |:||  ..:..|:.:...|......::.::|....|....|..
 Worm  1116 AYIFVWTLEIGRKVVSTIMMDTSKPV--LKQLRVFFFQYRNGLLAFGLLTYLIAYFIRLSPTTKT 1178

  Fly   980 IGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYP 1044
            :||::...:|:.|.|::::.|.|.:.|||.:.::.:|:..||...||:.:.|.:||:.||:|.||
 Worm  1179 LGRILIICNSVIWSLKLVDYLSVQQGLGPYINIVAEMIPTMIPLCVLVFITLYAFGLLRQSITYP 1243

  Fly  1045 NKQPTWSLIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAAT 1109
            .:...|.|::
 Worm  1244 YEDWHWILVR------------------------------------------------------- 1253

  Fly  1110 TSTTAPIHNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDIDPPCG-------EDPSQP-------- 1159
                                |:..||||||||||:|.:|| .||       ||.:.|
 Worm  1254 --------------------NIFLQPYFMLYGEVYAAEID-TCGDEIWQTHEDENIPISMLNVTH 1297

  Fly  1160 -GCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVL 1223
             .||.|:|:.|:.:::::|..|:||:|:::|....||.:....:.::::|:|:..||||:..|.|
 Worm  1298 ETCVPGYWIAPVGLTVFMLATNVLLMNVMVAGCTYIFEKHIQSTREIFLFERYGQVMEYESTPWL 1362

  Fly  1224 PPPFIALCHFYSLLKYCVRKAKGLEVQR--DNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIIL 1286
            ||||..:.|...|.|.....::..|.:.  |..|||||..|::|:::.||||.||....|.|...
 Worm  1363 PPPFTIIYHVIWLFKLIKSSSRMFERKNLFDQSLKLFLSPDEMEKVHTFEEESVEDMKRETEKKN 1427

  Fly  1287 NQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMS 1351
            ..|.|||:..|.||.:.:..::..:.|.|......::.:|.:::.|:...::.::.:..:::.:.
 Worm  1428 LSSNDERIHRTAERTDAILNRVSHLTQLEFTLKEEIRELEHKMKNMDSRHKEQMNLMLDMNKKLG 1492

  Fly  1352 THTAGADDLRGSTINIPGEMQRMRTISISDTEGGSGPGGNGGGGGGGGAIV-------------- 1402
            ...:|... |||.                   |||  |.:||||....:.:
 Worm  1493 KFISGKYK-RGSF-------------------GGS--GSDGGGGSSDNSKLEPNNSVPMITVDGP 1535

  Fly  1403 -PLG----LGAGLNLNSLQ----VTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKS 1458
             |:|    .|..|..:|||    :|..||  .||.:.:..:..|:         |.|:.||  .:
 Worm  1536 SPIGSRRTSGQYLKRDSLQAKKKITENRR--SSLEQPKIPSIQFN---------LMEDQDE--SA 1587

  Fly  1459 REALNEQV----------VRKA--SMQSEADSDIYIPVSQRPSTCETVKRTP-----YVTV---- 1502
            .|:..|:|          ||:.  |.:|:...|..|.....|.|...:.|.|     |.|:
 Worm  1588 AESATEEVSISIPVPQMRVRQVTESDKSDLSEDDLITREDAPPTSINLPRGPRRHALYSTIADAI 1652

  Fly  1503 --RQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPDINFE 1544
              ..|..|.:.....:||:  ...|.:..|.::|.....|.::|
 Worm  1653 ETEDDFYADSPVPMPMTPV--QPADGSFFGENDSRYQRDDSDYE 1694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	110/276 (40%)
		TRPV	<872..1227	CDD:454755	103/376 (27%)
		TRPM_tetra	1291..1346	CDD:465156	10/54 (19%)
gtl-1	NP_502111.3	LSDAT_euk	208..471	CDD:465665	110/276 (40%)
		DUF6056	1078..>1191	CDD:437360	31/114 (27%)
		TRPV	<1192..1369	CDD:454755	65/252 (26%)