Protein Alignment Trpm and ced-11

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_499021.1
• Gene: ced-11 / 176288
• WormBaseID: WBGene00000425
• Length: 1418
• Species: Caenorhabditis elegans
• Alignment Length: 1415
• Identity: 256/1415 - (18%)
• Similarity: 464/1415 - (32%)
• Gaps: 448/1415 - (31%)

  Fly    74 QTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEW 138
            |..|.:..|||..|....||...:...|...:: ||                .|:|::.|
 Worm    31 QLCPALILGSPQALPGAIKHIYSRLAAAASEVD-QG----------------VPDLIISL----- 73

  Fly   139 NLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQ 203
                      :..|.:   |..|....:..||.......|.|:.:.|       :|.|.:
 Worm    74 ----------ISHGNS---LSTKYMSSVENGLKSFLIGCGTWLISSG-------EVNDPM----- 113

  Fly   204 QRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGA 268
               .||.|      |.::.....|.|..||           |.:|.|...  ::..:.|.:|...
 Worm   114 ---SRVAS------GALKNVLPQLEHQAEV-----------LHILVNSDD--MIASDTTNSKSVV 156

  Fly   269 E-------LILRRK----LEKFISNL-KLHPSKNHWLKTNVTHSSTPVVCLV------IEGGT-- 313
            :       ||.|::    .|...|:: ||..:      |.|..:..|...|:      :...|
 Worm   157 DTSLNTLLLICRKEPNDSYETVASSIAKLRAA------TAVKLAHPPPALLIGVPSEPMSPSTYG 215

  Fly   314 NTIRAVLEYVTDSPPVPVVVCDGSGR---------------------AADLLAFVHK-----YAS 352
            |:...:|....|..|.||.:..|:.:                     :.:|.|.:|.     ..|
 Worm   216 NSAAILLSPSNDKRPFPVAIFAGASKESLIELLFFVEHGIPVIILQDSCELCAILHSSHLLLETS 280

  Fly   353 DGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQ 417
            :.:....:..:|..|       :.:||.....|..:||.   :.|...|..|:.....:..||..
 Worm   281 NFDNDKFISWLRSQL-------YPLGLADCYTLITKLLV---SSNSGDVQLIEFIDSSQLSELSS 335

  Fly   418 TIL--------------TALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMM 468
            .::              ..|..:..|:.|..||      .:|:|             ..|||.::
 Worm   336 VVVDRCLECYATTGEERQVLLLAAKLNSPSVLS------SMDVA-------------AQLDEELL 381

  Fly   469 QAL------EHDRIDFVKLLLE-----NGVSMKKFLTIPRLEELYNTKHGPANTLG--YILRDVR 520
            ..:      :.|::.|:..:|:     ...|......:...:|.:.|.......:|  ||..::.
 Worm   382 TMILCECITKDDQLHFLSSVLQLSPPIRVTSNMLIRMMHHADEHFFTTIVLCQCMGYSYIPSEID 446

  Fly   521 PHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGAN 585
            |..       .:||..::.||      |:.....|.|      |.:.|.......::..|.
 Worm   447 PRF-------ANDIQKLVKKL------SFGVDNLFDP------NVFCNDSSHRDKHESIRI---- 488

  Fly   586 SLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHE 650
                                    |.||::|..|..:...:....:|.:|.|:|..::.:::.||
 Worm   489 ------------------------LAIWSLLLHRPGIVKCLAAFADEPVAFSMVLSRIARSLGHE 529

  Fly   651 AAEDDLDTEIYEE-LRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAAN 714
            :.    |...||: |.:.:.........|.|..:.....||.:||...:..:...:...||...|
 Worm   530 SH----DWHFYEKSLNTLSDSLSGSATTLFDTVFSTSPAKAYQLLCQPMEYFYGFNMTQLAFHCN 590

  Fly   715 HRALLAHPCSQVILADLWMGGLRTRKNTNFKVILG----------LAMPFYIRQLDFKSKEELQQ 769
            .|.::||.|.|..:.....|.|:.:   ||.:.|.          |.:|.....| .:.:|..:|
 Worm   591 AREIIAHECCQRWVHRKLYGNLQAK---NFPIFLPKWAKICISAVLIIPVKFWML-VRPRERTKQ 651

  Fly   770 MPQTEEEHLENQNLDNDDSDRSQPDAESALL------KAKRSISLRYRMGAGANNRDKALLADTY 828
                               |...|..  |||      :.:|:|| .|.:   .::|.:||.|.|.
 Worm   652 -------------------DTVSPTV--ALLDVGKFPQKQRAIS-TYSV---ISSRSEALTALTA 691

  Fly   829 SVRDTKVHENGKVSLTDSDTAQFREF-FNLSEYNEVKQHQPLRLKKKFYE--------FYTAPIT 884
            .: .|....|..::..:|.|.|...| .|:.|.:  |..:|...|.:...        ||:.||.
 Worm   692 PL-STAFGFNSALNGAESATPQSMVFPLNIEEID--KDPRPFGKKNRIRRAHAPTLSTFYSTPIV 753

  Fly   885 KFWADSIAYMFFLIMFSFTVLVKMEQMPRWQE---------WYSIAYITTLGFEKVREIISSEPV 940
            |:|...:..:.|:...:::|::.......|..         |....::.|....|:       |:
 Worm   754 KYWLSLLFRIVFICCLAYSVVLPGCGSNLWDTGMWVWSFFWWIENCFVLTARARKI-------PL 811

  Fly   941 AITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDIGRV-----IYCVDSIY--------- 991
            ::.         .|...|..|..:|:|.|.      .|.:..|     :..:||||
 Worm   812 SLM---------PWRVFDVFAFFVFLILLL------VMKVFPVTPVLEVLGIDSIYSAKVVSAFF 861

  Fly   992 ----WYLRILNILGVNKYLGPLVTMMGKM-VKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWS 1051
                .|..:...:.::...||::..:..| :::...|:.::|:|::|..|:.||:::|::..|..
 Worm   862 VLYVSYSTLFTYIPLSDIFGPMIVRVKLMLLRDFTNFLFMIALVMLSSAVAIQAVVFPDRPVTME 926

  Fly  1052 LIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPI 1116
            :.::.::. |....|...|.:.:.|...| ...:|||
 Worm   927 VFRKTLSW-IWLSLFTTDLSNLSESETCR-KSFLGAP---------------------------- 961

  Fly  1117 HNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLLIANI 1181
                             :.|....|:.             :.|.|.:......:.:..|.:|..:
 Worm   962 -----------------KRYCSSVGQY-------------ANPSCPSQSLPAYLIVIEYFVILKL 996

  Fly  1182 LLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKG 1246
            ||..:|.|.|:.....|:..:.::|.||.:::..:::.:|.||||....|...|.   |.|.:
 Worm   997 LLWPILFAFFSKTAKNVDDEADKIWRFQLYSLAEDFRLRPPLPPPLTIFCLICSA---CCRFS-- 1056

  Fly  1247 LEVQRDNGLKLFLEKDDLERLYDFE------------------------EECVEGFFHEQEIILN 1287
                  |....|....|..   |||                        .|.|..|:.:..:
 Worm  1057 ------NSFSGFFSDFDHP---DFEARDKCRTTWKFGSIYRNPSVPFKRNEFVNSFWRKLSM--- 1109

  Fly  1288 QSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSE 1337
                |:.|||.::.:..:.|.| :.:..||..      ..|:..:.:|.|
 Worm  1110 ----EQWKNTQQKAKISANKSE-LQELHNIHN------HIRMMTLRDSYE 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	56/321 (17%)
		TRPV	<872..1227	CDD:454755	66/390 (17%)
		TRPM_tetra	1291..1346	CDD:465156	11/47 (23%)
ced-11	NP_499021.1	TRPV	<856..1024	CDD:454755	34/227 (15%)
		NUDIX_Hydrolase	1249..>1268	CDD:469772