Protein Alignment Trpm and Trpm1

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_001034193.2
• Gene: Trpm1 / 17364
• MGIID: 1330305
• Length: 1622
• Species: Mus musculus
• Alignment Length: 1786
• Identity: 657/1786 - (36%)
• Similarity: 926/1786 - (51%)
• Gaps: 412/1786 - (23%)

  Fly    39 RSWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSPGDL-------------WLP 90
            ::|||..|.|||||..||..||..:||||  |:|:|.||.:.||:|...             |..
Mouse    28 KAWIEKTFCKRECIFVIPSTKDPNRCCCG--QLTNQHIPPLPSGAPSTTGEDTKQADTQSGKWSV 90

  Fly    91 TKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKAN 155
            :|||:..|||:||.:|||||.:..||.|:|:|:||:|:.|:.|..|:|.||||||||:|.||..:
Mouse    91 SKHTQSYPTDSYGILEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQS 155

  Fly   156 FDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIV 220
            |::|.|||:...|||:|||.||||||||||.:|||...|||||.....:..||:.:|||||||:|
Mouse   156 FEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVVSHVGDALKDHSSKSRGRLCAIGIAPWGMV 220

  Fly   221 ERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKL 285
            |...:|:|.:......::|:|.|||:||||.|.:|:|.||||..|||||:.|||:|||.||..|:
Mouse   221 ENKEDLIGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRQLEKHISLQKI 285

  Fly   286 HPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKY 350
            :....         ...|||.||:|||.|.:..||||:.:.||||||||||||||:|:|:|.|||
Mouse   286 NTRLG---------QGVPVVGLVVEGGPNVVSIVLEYLKEDPPVPVVVCDGSGRASDILSFAHKY 341

  Fly   351 ASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQEL 415
            ..:|  ..:.||:||.|:.||||||.....||.:|:..:::|.:.|.|:||||:..  ||: |::
Mouse   342 CDEG--GVINESLRDQLLVTIQKTFNYSKSQSYQLFAIIMECMKKKELVTVFRMGS--EGQ-QDV 401

  Fly   416 DQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPN-------------------- 460
            :..|||||.|..:.|.|:||||||.|||||||||:|||:|..||.
Mouse   402 EMAILTALLKGTNASAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPVDTKATEKEKKPP 466

  Fly   461 -------------------------------------GALDEAMMQALEHDRIDFVKLLLENGVS 488
                                                 .||::||:.||..||:||||||:||||:
Mouse   467 TATTKGRGKGKGKKKGKVKEEVEEETDPRKLELLNWVNALEQAMLDALVLDRVDFVKLLIENGVN 531

  Fly   489 MKKFLTIPRLEELYNTKHGPANTLGYILRDV-RPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTR 552
            |:.|||||||||||||:.||.|||..::||| :.::|..|..:|.|||||:..|||||||..|||
Mouse   532 MQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTR 596

  Fly   553 RKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSE------------------ 599
            :.||.:|             ::.:..:|......|.:.....|...:
Mouse   597 KSFRTLY-------------NNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDP 648

  Fly   600 -MALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEE 663
             ::.|::||:||::||||.|||:||:.:|..|||.:||:||:||||||||||::|.:|..:|.::
Mouse   649 AVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEECMAKALVACKLYKAMAHESSESELVDDISQD 713

  Fly   664 LRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVIL 728
            |.:.:|:|.....:|||.||:.|.:.|.:|||.||.:|||.:||.|||||.||..:||.|||::|
Mouse   714 LDNNSKDFGQLAVELLDQSYKHDEQVAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLL 778

  Fly   729 ADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQP 793
            .|:|||.||.|||...|||:|:.:|..|..|:|::.::...  ||.:|     |.|..:.:....
Mouse   779 TDMWMGRLRMRKNPGLKVIMGILIPPTILFLEFRTYDDFSY--QTSKE-----NEDGKEKEEENV 836

  Fly   794 DAESALLKAKRSISLRYRMGAGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLS 858
            ||.:               .||:...|
Mouse   837 DANA---------------DAGSRKGD-------------------------------------- 848

  Fly   859 EYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYI 923
            |.||.|:.:.:.:..|..|||.|||.|||..:|:|:.:|::|::.:||:|:..|..|||..|:||
Mouse   849 EENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSPQEWIVISYI 913

  Fly   924 TTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENT-MDIGRVIYCV 987
            .:|..||:|||:.|||..::.|..||....||..|..||.:|::|...|.:... |..|||||||
Mouse   914 VSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMVGAILRLQSQPYMGYGRVIYCV 978

  Fly   988 DSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSL 1052
            |.|.||:|:|:|.||||||||.|.|:|||:.:|:||||::.||||||||:|||||:|.::|:|.|
Mouse   979 DIILWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKL 1043

  Fly  1053 IKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIH 1117
            .:
Mouse  1044 AR--------------------------------------------------------------- 1045

  Fly  1118 NEHSNLTSGNLTNVTFQPYFMLYGEVFAGDID-------PPCGED------PSQPGCVTGHWVTP 1169
                        |:.:.||:|:||||||..||       |||||:      ...|.|:.|.|:||
Mouse  1046 ------------NIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTP 1098

  Fly  1170 ITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFY 1234
            ..|:.|||:|||||:|||||||||.|.||.|:|:|||.|||:.::|.:..:||||||.|.|.|.|
Mouse  1099 ALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIY 1163

  Fly  1235 SLLK----YCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVK 1295
            .::.    .|.:|.:|.:.:||.||||||..::|::|::|||:||:..|.|:|.....|:|||::
Mouse  1164 IIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKKLHEFEEQCVQEHFREKEDEQQSSSDERIR 1228

  Fly  1296 NTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILS---HLAVIHR--FMSTHTA 1355
            .|:||||.||.::|:||::||....::|.::.||.::||.|.:::|   :||.|.|  .:...:.
Mouse  1229 VTSERVENMSMRLEEINERENFMKTSLQTVDLRLSQLEELSGRMVSALENLAGIDRSDLIQARSR 1293

  Fly  1356 GADD------LRGSTIN--------------------------IPGEMQRMRTIS---------- 1378
            .:.:      ||.|:||                          .||...|.:|.|
Mouse  1294 ASSECEATYLLRQSSINSADGYSLYRYHFNGEELLFEEPALSTSPGTAFRKKTYSFRVKDEDAKS 1358

  Fly  1379 -------ISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRPDAYI 1436
                   :..|.|.|.|...|..        .|.|...|:                ||:||.:
Mouse  1359 HLDQPSNLHHTPGPSPPATPGRS--------RLALEGPLS----------------TELRPGS-- 1397

  Fly  1437 FDEGTHFEVVPLPE-EPDEVVKSREA---LNEQVVRKASMQSEA-------DSDI--YIPVSQRP 1488
             |.|     :...| :|....||.||   ||...|....:..|:       :|.:  |.|..  |
Mouse  1398 -DPG-----ISAGEFDPRADFKSTEAAPSLNAAGVTGTQLTVESTDSHPLRESKLVRYYPGD--P 1454

  Fly  1489 STCETVKRTPYVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQ 1553
            :|.:|:|...:|        .||.:..:..:.|...:.:.:    .|.|.....:.....|..|.
Mouse  1455 NTYKTMKSRSFV--------YTEGRKLVRGLSNWSAEYSSI----MDQAWNATEWRCQVQRITRS 1507

  Fly  1554 RTVSLCRRNSETY-----------SLTGADINRSHISLNQLASLSRRQMSLTQSEPDSDKDAPIA 1607
            |:..:....||..           ||....|:||.::::.    ...:.:|...:|......|..
Mouse  1508 RSTDIPYIVSEAASQDELEDEHRGSLLDPQISRSALTVSD----RPEKENLLSVKPHQTLGFPCL 1568

  Fly  1608 QG--------SAHPGKSVL----HAKPSRNI 1626
            :.        ||.|..|.|    ||..:.|:
Mouse  1569 RSRSLHGRPRSAEPAPSKLDRAGHASSTSNL 1599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	142/275 (52%)
		TRPV	<872..1227	CDD:454755	152/368 (41%)
		TRPM_tetra	1291..1346	CDD:465156	24/57 (42%)
Trpm1	NP_001034193.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..95		7/30 (23%)
		LSDAT_euk	116..381	CDD:465665	142/275 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..490		0/39 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	618..641		2/22 (9%)
		TRPV	<757..1155	CDD:454755	196/532 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..856		12/91 (13%)
		TRPM_tetra	1224..1279	CDD:465156	22/54 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1354..1383		5/36 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1389..1408		8/42 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1567..1622		8/33 (24%)