Protein Alignment Trpm and Trpm4

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_001129701.1
• Gene: Trpm4 / 171143
• RGDID: 620244
• Length: 1208
• Species: Rattus norvegicus
• Alignment Length: 1441
• Identity: 371/1441 - (25%)
• Similarity: 615/1441 - (42%)
• Gaps: 376/1441 - (26%)

  Fly    33 VPRHQPRSWIETNFQKRECIKFIPCPKDD---TKCCCGQAQITHQTIPGIESGSPGDL---WLPT 91
            |.:.:.:|||...|:|:.|..||....||   |.|.|||.:..|.:: .:|......:   |...
  Rat     2 VGQEKEQSWIPKIFRKKVCTTFIVDLHDDAGGTLCQCGQPRDAHPSV-AVEDAFGAAVVTEWNSD 65

  Fly    92 KHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANF 156
            :||..:||||||.::|......: :.::|||..|.|..:..|.|:.|....|.|:::|.||....
  Rat    66 EHTTEKPTDAYGDLDFTYSGRKS-SNFLRLSDRTDPATVYSLVTRSWGFRAPNLVVSVLGGSEGP 129

  Fly   157 DLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTG--RVVSIGIAPWGI 219
            .||..|:..:|:||::||::|||||.|||.:||:.:.||.|:.......||  :||::|:||||:
  Rat   130 VLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQTASTGGSKVVAMGVAPWGV 194

  Fly   220 VERNHELLGHN----------REVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRR 274
            | ||.::|.:.          |..|...:..|      |:..::.|.|||:||..:.|.|...|.
  Rat   195 V-RNRDMLINPKGSFPARYRWRGDPEDGVEFP------LDYNYSAFFLVDDGTYGRMGGENRFRL 252

  Fly   275 KLEKFISNLKLHPSKNHWLKTNV--THSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGS 337
            :.|.:::.          .||.|  |....||:.|:|||....::.: |..|.: .:|.::..||
  Rat   253 RFESYVAQ----------QKTGVGGTGIDIPVLLLLIEGDEKMLKRI-EDATQA-QLPCLLVAGS 305

  Fly   338 GRAADLLAFVHKYASDGEEQPVLESMRDYLI------------GTIQKTFEVGLDQSEKLYQELL 390
            |.|||.|               :|::.|.|.            ..|::.|..|  ..|.|..::.
  Rat   306 GGAADCL---------------VETLEDTLAPGSGGLRRGEARDRIRRYFPKG--DPEVLQAQVE 353

  Fly   391 QCTRNKNLITVFRIQEKPEGEAQELDQTILTALFK----SQHLSPPEQLSLALTWNRVDIARSEI 451
            :....|.|:||:    ..|..::|.:..:|.||.|    |:..:..::|.||:.|||||||:||:
  Rat   354 RIMTRKELLTVY----SSEDGSEEFETIVLRALVKACGSSEASAYLDELRLAVAWNRVDIAQSEL 414

  Fly   452 FVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELY-------------- 502
            |....:|.:..|:.::|.||.:||.:||:||:.:|:|:..|||..||.:||
  Rat   415 FRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPVRLAQLYSAVSPNSLIRNLLD 479

  Fly   503 ------NTKHGPANTLGYILRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAK 561
                  ::|..|||...    ::||          .::|.|:..|:|......|..|.
  Rat   480 QASHASSSKSPPANGAA----ELRP----------PNVGQVLRTLLGETCAPRYPARN------- 523

  Fly   562 VMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLM 626
                    .|.|...|..|    .:.||:........:.:..:.|:::|||||:|..|.|||:..
  Rat   524 --------TRHSLLGQDHR----ENDSLLMDWANMQQDASFEQAPWSDLLIWALLLNRAQMAIYF 576

  Fly   627 WTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELR--SYAKEFESKGNKLLDFSYRQDAEK 689
            |..|..::|.:|.:|.|.:.||.      |:.|..|..|  ..|.:|||....|....|.....:
  Rat   577 WEKGSNSVASALGACLLLRVMAR------LEWEAEEAARRKDLAAKFESMSVDLFGECYHNSEYR 635

  Fly   690 AQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPF 754
            |.|||......|...:||.||:.|:.||..|....|.:|...|.|.:   .:||  .|..|.:.|
  Rat   636 AARLLLRRCPLWGEATCLQLAMQADARAFFAQDGVQSLLTQKWWGEM---DSTN--PIWALLLTF 695

  Fly   755 YIRQLDF-------KSKEELQQMPQTEEEHLENQNLDND-DSDR--------SQPDAESALLKAK 803
            :...|.:       ||:||..|           ::||.| ||..        ::|.|:.||.:.:
  Rat   696 FCPPLIYTNLILFRKSEEEPTQ-----------KDLDFDMDSSMNGAGPLGPAEPSAKVALERRR 749

  Fly   804 RSISLRYRMG-----AGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEV 863
            |.     |.|     .|.:
  Rat   750 RR-----RPGHTLCCGGCS---------------------------------------------- 763

  Fly   864 KQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKME-QMPRWQEWYSIAYITTLG 927
                     |::..|:.||:|.|..:.::|:.||::|:..:||..: ..|...|.....:..||.
  Rat   764 ---------KRWSYFWGAPVTAFLGNVVSYLLFLLLFAHVLLVDFQPTKPGVFELLLYFWAFTLL 819

  Fly   928 FEKVRE--------IISSEP----VAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDI 980
            .|::|:        :.:..|    ..:.|:..::..:.||.||..|:..|::|:..|......|:
  Rat   820 CEELRQGLGGGWGTLANGGPGPGKAPLRHRLHLYLLDTWNQCDLLALTCFLLGVGCRLTPGLFDL 884

  Fly   981 GRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPN 1045
            ||.:.|:|.:.:.||:|:|..|||.|||.:.::.||:|::.:|:..|.|.|:::||:.:.||.|.
  Rat   885 GRTVLCLDFMIFTLRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLCVWLVAYGVATEGILRPQ 949

  Fly  1046 KQPTWSLIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATT 1110
            .:...|:::.|.
  Rat   950 DRSLPSILRRVF----------------------------------------------------- 961

  Fly  1111 STTAPIHNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDID------PPCG---------EDPSQPG 1160
                                  ::||..::|::...::|      ..|.         |.|....
  Rat   962 ----------------------YRPYLQIFGQIPQEEMDVALMNPSNCSAERGSWAHPEGPVAGS 1004

  Fly  1161 CVT--GHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVL 1223
            ||:  .:|:..:.:.::||:|||||:|||||:|:..||:|:..|...|..||::::.|:..:|.|
  Rat  1005 CVSQYANWLVVLLLIVFLLVANILLLNLLIAMFSYTFNKVHGNSDLYWKAQRYSLIREFHSRPAL 1069

  Fly  1224 PPPFIALCHFYSLLKYCVRKAKGLEVQRDN--------GLKLFLEKDDLERLYDFEEECVEGFFH 1280
            .||.|.:.|...|.|:..|      ..|.|        ..::.|.|:....|..:|.      .|
  Rat  1070 APPLIIISHLRLLFKWLRR------CHRTNLPASPVFEHFRVCLSKEAERTLLTWES------VH 1122

  Fly  1281 EQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSE-------- 1337
            ::..:|.|:.|:| .:.:||::..|||::...:    |...::..:.|||.:|...:
  Rat  1123 KENFLLAQARDKR-DSDSERLKRTSQKVDTALK----QLGQIREYDRRLRGLEREVQHCSRVLTW 1182

  Fly  1338 --QILSHLAVI 1346
              :.|||.|::
  Rat  1183 MAEALSHSALL 1193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	89/301 (30%)
		TRPV	<872..1227	CDD:454755	91/384 (24%)
		TRPM_tetra	1291..1346	CDD:465156	16/64 (25%)
Trpm4	NP_001129701.1	LSDAT_euk	89..346	CDD:476852	87/292 (30%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q7TN37	969..971		0/1 (0%)
		Calmodulin-binding. /evidence=ECO:0000250	1070..1170		27/116 (23%)
		Mediates modulation by decavanadate and PIP2-binding. /evidence=ECO:0000250|UniProtKB:Q8TD43	1130..1135		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1189..1208		2/5 (40%)