Protein Alignment Trpm and trpm4

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_002934673.1
• Gene: trpm4 / 100491327
• XenbaseID: XB-GENE-960842
• Length: 1218
• Species: Xenopus tropicalis
• Alignment Length: 1407
• Identity: 371/1407 - (26%)
• Similarity: 633/1407 - (44%)
• Gaps: 318/1407 - (22%)

  Fly    39 RSWIETNFQKRECIKFIPCPKDD---TKCC-CGQAQITHQTIPGIESGSPGDL---WLPTKHTRP 96
            :|||...|:|:.|..||...||.   ||.| ||...|.|.:: .:|......:   |...:||..
 Frog     9 QSWIPKLFKKKTCTTFIEDTKDSSSPTKLCQCGALMINHVSV-AMEDNFGAAMVSTWNSAEHTTE 72

  Fly    97 QPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAK 161
            :||||||.:||. ||....::::|||.||.|..:..|.|..|.:..|.|:::|.||..:|.::..
 Frog    73 EPTDAYGDVEFV-GAGRKHSKFIRLSNDTDPASVYSLITYNWKIPPPNLVVSVVGGDGDFKMKTW 136

  Fly   162 LKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDAL----LLEGQQRTGRVVSIGIAPWGIVER 222
            ||..:||||:|||::|||||.|||...|:.|.||:|:    ......|| :||::||||||||
 Frog   137 LKDILRKGLVKAAQSTGAWIMTGGMQVGIGKYVGEAVRDHATANSNSRT-KVVAMGIAPWGIV-- 198

  Fly   223 NHELLGHNREVPCHSISSPRSKLAV-------------LNNRHAYFLLVDNGTQAKYGAELILRR 274
                  |||:    |:.:|:.....             |:|.::.|||.|:||..:.|.|...|.
 Frog   199 ------HNRQ----SLVNPKGSFPATYYMDNVDGPTYSLDNNYSVFLLADDGTHGQMGGETSFRF 253

  Fly   275 KLEKFISNLKLHPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGR 339
            :||:.||..|........::       .||:|::|.|.:..:..|  |.....|:|.::..|||.
 Frog   254 RLEEHISRQKTGAGGKGSIE-------IPVLCMLIAGESKMLGRV--YNATKSPIPCLLVAGSGG 309

  Fly   340 AADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRI 404
            .||.||.:.      ||...|||:|..:...::..|.  .:...|:.:::.:...|::|:||:
 Frog   310 VADCLAEIL------EESIALESIRGLIEEKLKHYFP--NENLTKMVEKVERIVENRDLVTVY-- 364

  Fly   405 QEKPEGEAQELDQTILTALFKS--QHLSPP----EQLSLALTWNRVDIARSEIFVYGQ-EWPNGA 462
             ...:| .::.:..||.||.|:  :|.|..    ::|.||:.|||.|||::|:| :|: .|....
 Frog   365 -SDADG-IEDFETVILKALVKACKKHSSDAVEYLDELKLAVAWNREDIAKTELF-HGEILWKATD 426

  Fly   463 LDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYIL----------R 517
            ||:.|..||.:::..||||.::||:::..:||..||||||::...  |||.|.|          .
 Frog   427 LDDTMTDALINNKPKFVKLFVDNGLNIVDYLTYGRLEELYSSVLD--NTLLYQLLKSKHDEHRNS 489

  Fly   518 DVRPHIP--------KGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSS 574
            ..:.|..        ||..:.|:::..::..|:|....::||.         |:.:...:..|
 Frog   490 KTKDHHELLFMESNGKGREFKLYEVSKILRDLLGDVCTTFYTH---------VLGNMKGSVNK-- 543

  Fly   575 TYQYQRYAGANSLSLVTGLLPFTSEMALFEF-------PFNELLIWAVLTKRQQMALLMWTHGEE 632
                 |.:|..|:          .::|:.::       |:.:|.|||:|..|.:||...|..|.|
 Frog   544 -----RNSGKKSM----------EQIAVEKYQPRKSTSPWIDLFIWAILQNRDEMATYFWEMGSE 593

  Fly   633 ALAKSLVSCKLYKAMAHEAAEDDLDTEIYEEL--RSYAKEFESKGNKLLDFSYRQDAEKAQRLLT 695
            |:..:|.:.|:.|.::.      :::|..|.|  |..|.:||.....:.:..||....:|.:||.
 Frog   594 AVTSALAAMKILKELSR------MESEAEESLAMRDLAAKFEQLAIGVFNECYRNSENRAFKLLV 652

  Fly   696 CELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTN-FKVILGLAMP--FYIR 757
            .....|...:||.||..|:.|...|....|.:|.:.|.|  :..:||. :.::|....|  .|..
 Frog   653 RRSVIWGGATCLQLAYEADARNFFAQDGVQSMLTENWWG--QMAQNTPVWAMVLTFFCPPLIYTD 715

  Fly   758 QLDFKSKEELQQMPQTEEEHLENQNLDND---------DSDRSQPDAESALLKAKRSISLRYRMG 813
            .:.|||.:....:...  :.:|..:||.|         :.:....:||...||
 Frog   716 LITFKSIDHENGIESA--QRMEMDSLDTDIKTTVAEIMEGEEKDDNAEEVPLK------------ 766

  Fly   814 AGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEF 878
                                      |:|:..|.|.:      ..|...:|:.|..|..:::.:|
 Frog   767 --------------------------KMSVKKSKTKK------APEAEIIKEKQRPRWMQRWKQF 799

  Fly   879 YTAPITKFWADSIAYMFFLIMFSFTVLVKMEQM----PRWQEWYSIAYITTLGFEKVRE--IISS 937
            ::||:|.|:.:.:.|..||.:||:.:|::.:..    |...|:....:|.|:..|::|:  .:.:
 Frog   800 WSAPVTAFFGNVVMYFAFLFLFSYVLLLEFKMPPPDGPANSEFILYFWIFTMVCEEIRQSFFVGT 864

  Fly   938 EPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDIGRVIYCVDSIYWYLRILNILGV 1002
            .|||  .|...:..:.||..|..|:.||:|||..|....:.:.||.|.|.|.:.:.||:::|..|
 Frog   865 MPVA--QKVKQYLQDSWNHVDIIALCLFIIGLICRMFNESFEAGRTILCFDFMVFTLRLIHIFAV 927

  Fly  1003 NKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYP-NKQPTWSLIKEVIAGSITAPGF 1066
            ||.|||.:.::.||:|::.:|:..|.|.|:::||:.:.:|:| :.:.:|.
 Frog   928 NKQLGPKIIIVRKMMKDVFFFLFFLGVWLIAYGVTTEGLLHPTDMRLSWI--------------- 977

  Fly  1067 LGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGNLTNV 1131
                                                                         ...|
 Frog   978 -------------------------------------------------------------FRRV 981

  Fly  1132 TFQPYFMLYGEVFAGDIDPP------CGEDP-------SQPGCVT--GHWVTPITMSMYLLIANI 1181
            .::||..::|::...:.|..      |..||       ::| |..  .:|:..:.:.::||:|||
 Frog   982 FYRPYLQIFGQIPQEEFDASKIASSNCTNDPIAIMLEEAEP-CTNTYANWLVILLLVVFLLVANI 1045

  Fly  1182 LLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKG 1246
            ||:|||||:|:..|::|...|...|.|||:.:::||..:|.|.||||.:.|..:.:|..:||...
 Frog  1046 LLLNLLIAMFSYTFSKVQGNSDIYWKFQRYNLIVEYHNRPALAPPFIIISHINTFIKRKIRKVAS 1110

  Fly  1247 LEVQRDNGLKLFLEKDDL--ERLYDFEEECVEGFF-----HEQEIILNQSTDERVKNTTERVETM 1304
            .:::.     ..||..:.  .|:..:|....|.:.     |:::     |..||::.|:::|:..
 Frog  1111 QKIRH-----FMLELTETLDNRMLIWEAVQKENYMVSVAKHKRD-----SDTERLRRTSQKVDNA 1165

  Fly  1305 SQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVI 1346
            .:.:.:|.:.:.           ||:.||...|...:.|:.|
 Frog  1166 LKLLNEIKEHDR-----------RLKAMENEMEYCRNALSWI 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	94/292 (32%)
		TRPV	<872..1227	CDD:454755	93/376 (25%)
		TRPM_tetra	1291..1346	CDD:465156	11/54 (20%)
trpm4	XP_002934673.1	LSDAT_euk	91..315	CDD:476852	84/245 (34%)
		Ion_trans	815..>945	CDD:459842	42/131 (32%)