Protein Alignment Trpm and trpm6

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_031746734.1
• Gene: trpm6 / 100487366
• XenbaseID: XB-GENE-958179
• Length: 2036
• Species: Xenopus tropicalis
• Alignment Length: 1954
• Identity: 630/1954 - (32%)
• Similarity: 934/1954 - (47%)
• Gaps: 415/1954 - (21%)

  Fly    39 RSWIETNFQKRECIKFIPCPKDD-------------TKCCCGQAQITHQTIPGIESGSP------ 84
            :||||..|.||||.|.||..|:.             .:||||:....|   ||::.|.|
 Frog     9 KSWIEGLFNKRECAKIIPSSKEPHRCHGGCQVCQNLIRCCCGRLIGDH---PGLDYGWPINPSPQ 70

  Fly    85 ---GDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLL 146
               .:.|....||:|.||||:|||.||.|.|...|:|:|:|:||..|||:.|..|||.:|||||:
 Frog    71 EREDEEWSILNHTKPSPTDAFGTINFQDGDHTYHAKYIRISYDTTLELLMHLMIKEWQMELPKLV 135

  Fly   147 ITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVS 211
            |:|.||..||.|.:|:|:...|||:|||:||||||.|.|.|||.:|.|||||.....|...::.:
 Frog   136 ISVHGGIQNFKLPSKIKQVFGKGLVKAAETTGAWILTEGINTGASKHVGDALKAHASQHLRKICA 200

  Fly   212 IGIAPWGIVERNHELLGHNREVPC--HSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRR 274
            :||.|||.:|...:|:|  ::|.|  .::.:|.|||..||:.|::|::||:||..|||.|:.|||
 Frog   201 VGIPPWGAIENQQDLIG--KDVVCLYQTLINPMSKLTSLNSMHSHFIMVDDGTVGKYGNEMKLRR 263

  Fly   275 KLEKFISNLKLHPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGR 339
            .||.|||..|:|....         ...|||.||||||.|.|..|.|||..:||||||||:|:||
 Frog   264 NLEDFISLQKIHTRMG---------QGVPVVGLVIEGGPNVILMVWEYVRSTPPVPVVVCEGTGR 319

  Fly   340 AADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRI 404
            |||:|||.||:.:|.|:  :...:::.::..|||||.:|..||..:...|::|...:..||:|..
 Frog   320 AADILAFTHKHTTDTEQ--ISPQLKEEILEMIQKTFNLGHRQSNHVLYILMECMERRASITIFDA 382

  Fly   405 QEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQ 469
            :.:   |.|::|..|||||.|..::|..:||||||||||||||:..|.:|||.|..|:|::||..
 Frog   383 ESE---EQQDIDLAILTALLKGTNMSAQDQLSLALTWNRVDIAKKHILIYGQHWKVGSLEQAMQD 444

  Fly   470 ALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPAN-TLGYILRDVRPHIPK-GYIYTLH 532
            ||..||:||||||:|.||:|.:||||..||||||||.||.| .|.:::|||:...|. .|..:|.
 Frog   445 ALVMDRVDFVKLLIEYGVNMHRFLTIGHLEELYNTKQGPTNLLLHHLVRDVKQSNPSPDYRISLI 509

  Fly   533 DIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSY------------------------------- 566
            |:||||..|:||||||.|||:.||.:|..:...:
 Frog   510 DVGLVIEYLIGGAYRSSYTRKSFRVLYNSLFRKHKKSVPSSSSSLAQSLSHLSINQSSQMSSKLE 574

  Fly   567 -------------ANAC-RKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLT 617
                         |..| ||..|..:|:....:.::...     .:|...|.:|:|:||:||||.
 Frog   575 SPESTLHSQFFRTAQPCRRKDKTTCHQKSKKKDEVTCTE-----DNEPVGFIYPYNDLLVWAVLM 634

  Fly   618 KRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFS 682
            |||:||:..|.|||||:.|::::||||:||||||.:..:..:..|||:.|:|||......:|:.:
 Frog   635 KRQKMAMFFWQHGEEAMVKAVIACKLYRAMAHEAKQSTMVDDTSEELKKYSKEFGQLALDILENA 699

  Fly   683 YRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVI 747
            ::.:.:.|.:|||.:|.:|||.:||.|||::..|..::|.|:|::|.|:|||.|:.||::..|||
 Frog   700 FKMNEQMAMKLLTYQLKNWSNSTCLKLAVSSTLRPFVSHTCTQMLLTDMWMGRLKMRKHSWLKVI 764

  Fly   748 LGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAESALLKAKRSISLRYRM 812
            ||:.:|.::..|:||:|.|:..:||:.|.|         ...|...|..|...|.:.........
 Frog   765 LGILLPPFVLMLEFKTKAEMSHVPQSLEFH---------QFSRLYVDPPSLSTKEEHITDFDAER 820

  Fly   813 GAGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYE 877
            |:.....|                :|.|:|                  |.:   ..|.:.:|..|
 Frog   821 GSKQPGED----------------QNQKIS------------------NGL---GILPITRKICE 848

  Fly   878 FYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAI 942
            ||:|||.|||..::.|:.||::|::||||||:..|..|||..|.||.|...|||||:..|||...
 Frog   849 FYSAPIVKFWFHTMVYLAFLMLFTYTVLVKMDPQPSVQEWCVIIYIFTTAVEKVREVFVSEPGKF 913

  Fly   943 THKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMD-IGRVIYCVDSIYWYLRILNILGVNKYL 1006
            :.|..||....||..|..||.||.||...|:.:.... .||:|||:|.|:||:|:|:...||:..
 Frog   914 SQKVKVWINEYWNLTDSIAIFLFFIGFGLRWPDPPFQTAGRIIYCLDIIFWYVRLLDFFAVNQQA 978

  Fly  1007 GPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIAGSITAPGFLGALG 1071
            ||.:||:|||..||...|:::|:||::|||||:|||.|:..|:|:|.::::
 Frog   979 GPYITMLGKMTSNMFGIVIIMAIVLLAFGVSRKAILSPDHPPSWTLARDIV-------------- 1029

  Fly  1072 HNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGNLTNVTFQPY 1136
                                                                         ||||
 Frog  1030 -------------------------------------------------------------FQPY 1033

  Fly  1137 FMLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSV 1201
            :|::|||:||:|| .|.|||.   |..|.::||...::||.:..|:::||||::|||::..:|||
 Frog  1034 WMMFGEVYAGEID-ACEEDPD---CPPGSFITPFLQAVYLFVQYIIMVNLLISLFNNVYRVLNSV 1094

  Fly  1202 SHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEV---QRDNGLKLFLEKDD 1263
            ||::|.:.|:..:|.|.:||.||||.|.|.|.|.|:..........|.   :.|.||||:|..::
 Frog  1095 SHKLWKYNRYRYIMTYYEKPWLPPPLIFLSHIYILINRLCHHRSHSEFDPEETDMGLKLYLSDNE 1159

  Fly  1264 LERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFR 1328
            |.:|:||||:|||.:|||:...|:.|.:||::.||||.|.|..:::::|.|......::.:::.:
 Frog  1160 LRKLHDFEEKCVETYFHEKNESLHSSKNERIRVTTERTEEMFAQLKEVNDKVFYIKDSLSSLDSQ 1224

  Fly  1329 LRKMEESSEQILSHLAVIHRF--MSTHTAGADDLRGSTI--------NIP-GEMQR--------- 1373
            |..:::.|...:..|.:|...  :....|...|.:|.|.        |:| ...||
 Frog  1225 LGHLQDLSALTVDTLKIISAVDSLQVEEAFIKDKKGLTCKKLPHSWSNVPYSHHQREYNYYSMPP 1289

  Fly  1374 --MRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSL------QVTTRRRFNRS---- 1426
              :||::.|...                              ||      |:|.:...:.|
 Frog  1290 SLLRTLARSQCP------------------------------SLYQCPPQQLTAQLEIHNSEEPK 1324

  Fly  1427 -----LTEVRP-DAYIFDEGTHFEVVPL--PEEP---------DEVVKSREALNEQVVRKASMQS 1474
                 :|...| |:.......::.:||.  |..|         .:::...||::.|...|..:.|
 Frog  1325 IEVDIVTMAVPLDSKSAQHYGNYLLVPSVGPPAPTDSAFKETCSDMLSEGEAISVQATTKERICS 1389

  Fly  1475 EADSDIYIPVSQRPSTCETVKRTPYVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATP 1539
             ..||..:...|:     .||.:...|:::|          |.|:..|.|:..   .:.|.:.:.
 Frog  1390 -IHSDQCLCSKQK-----HVKESSRKTMKED----------LKPLVTNTDESQ---NEESHECSC 1435

  Fly  1540 DINFEAARHRALRQRTVSLCRRNSETYSLT---GADINRSHISLNQLASLSRRQMSLTQSEPDSD 1601
            |            |.|..:....|.|.::.   |..:|.:.....:.|..|........|.|...
 Frog  1436 D------------QFTAHVTVETSITCNIIDPGGGYVNLAFSEEGETALFSGGSSKTLCSRPTQS 1488

  Fly  1602 KDAPIAQGSAHPGKSVLHAKPSR-NILLKLHSEYTSITDELESVCHMIASPTVSLPSNKASLDRP 1665
                 ::.:..|.||    ..|| |...:..|.|...|..|::..:...||..|...:|
 Frog  1489 -----SKSNVFPNKS----DGSRANDRPEFGSGYKQKTSFLKNSLYRNNSPRGSSKRHK------ 1538

  Fly  1666 KTEMSRAEAAALLEKKHLKECEENDY-------MILEGLIESRGSIDASAQGFEIGVSIDYSHRY 1723
                         |||..|.|...|:       .:.....:.|.:...|.:.
 Frog  1539 -------------EKKDGKICTIKDFAKPPESSKVTWAKEKLRSTFRKSVKD------------- 1577

  Fly  1724 PLRRETAVELSPSKPSVDG---DLMGGGEGGGAGGGDSSDTSGAGSCGAMVGISSGFQLKNERPW 1785
               :....:|.....:|||   ......|....|...|.|.....    .:.:||..||..:...
 Frog  1578 ---KPRPTQLQVPVITVDGCSQSTQMSSEPADCGSWKSEDEPSKN----RLTVSSFNQLSLDHMT 1635

  Fly  1786 QRNSSMEQQTYPSPLVPTRATSDFLNPPYE----------GRLFKKSSE------SLQKNSSTET 1834
            .....::.|.:...||   .||::|....|          ..||:.|.|      ||:.:.....
 Frog  1636 YMRQQLKTQEFERHLV---QTSEYLRQSREDLHNTTQLRRSSLFRNSDEVKKMAASLKASQDLSN 1697

  Fly  1835 DYSA 1838
            .|||
 Frog  1698 HYSA 1701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	132/277 (48%)
		TRPV	<872..1227	CDD:454755	131/355 (37%)
		TRPM_tetra	1291..1346	CDD:465156	13/54 (24%)
trpm6	XP_031746734.1	LSDAT_euk	105..370	CDD:465665	132/277 (48%)
		TRPV	<724..1119	CDD:454755	172/519 (33%)
		TRPM_tetra	1187..1242	CDD:465156	13/54 (24%)
		Alpha_kinase_ChaK2_TRPM6	1725..1963	CDD:341222