DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and trpm6

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	XP_031746734.1	Gene:	trpm6 / 100487366	XenbaseID:	XB-GENE-958179	Length:	2036	Species:	Xenopus tropicalis

Alignment Length:	1852	Identity:	630/1852 - (34%)
Similarity:	934/1852 - (50%)	Gaps:	320/1852 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RSWIETNFQKRECIKFIPCPKDD-------------TKCCCGQAQITHQTIPGIESGSP------ 160
            :||||..|.||||.|.||..|:.             .:||||:....|   ||::.|.|
Frog     9 KSWIEGLFNKRECAKIIPSSKEPHRCHGGCQVCQNLIRCCCGRLIGDH---PGLDYGWPINPSPQ 70

  Fly   161 ---GDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLL 222
               .:.|....||:|.||||:|||.||.|.|...|:|:|:|:||..|||:.|..|||.:|||||:
Frog    71 EREDEEWSILNHTKPSPTDAFGTINFQDGDHTYHAKYIRISYDTTLELLMHLMIKEWQMELPKLV 135

  Fly   223 ITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVS 287
            |:|.||..||.|.:|:|:...|||:|||:||||||.|.|.|||.:|.|||||.....|...::.:
Frog   136 ISVHGGIQNFKLPSKIKQVFGKGLVKAAETTGAWILTEGINTGASKHVGDALKAHASQHLRKICA 200

  Fly   288 IGIAPWGIVERNHELLGHNREVPC--HSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRR 350
            :||.|||.:|...:|:|  ::|.|  .::.:|.|||..||:.|::|::||:||..|||.|:.|||
Frog   201 VGIPPWGAIENQQDLIG--KDVVCLYQTLINPMSKLTSLNSMHSHFIMVDDGTVGKYGNEMKLRR 263

  Fly   351 KLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVH 415
            .||.|||..|:|.......|||.||||||.|.|..|.|||..:||||||||:|:|||||:|||.|
Frog   264 NLEDFISLQKIHTRMGQGVPVVGLVIEGGPNVILMVWEYVRSTPPVPVVVCEGTGRAADILAFTH 328

  Fly   416 KYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQ 480
            |:.:|.|:  :...:::.::..|||||.:|..||..:...|::|...:..||:|..:.:   |.|
Frog   329 KHTTDTEQ--ISPQLKEEILEMIQKTFNLGHRQSNHVLYILMECMERRASITIFDAESE---EQQ 388

  Fly   481 ELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDF 545
            ::|..|||||.|..::|..:||||||||||||||:..|.:|||.|..|:|::||..||..||:||
Frog   389 DIDLAILTALLKGTNMSAQDQLSLALTWNRVDIAKKHILIYGQHWKVGSLEQAMQDALVMDRVDF 453

  Fly   546 VKLLLENGVSMKKFLTIPRLEELYNTKHGPAN-TLGYILRDVRPHIPK-GYIYTLHDIGLVINKL 608
            ||||:|.||:|.:||||..||||||||.||.| .|.:::|||:...|. .|..:|.|:||||..|
Frog   454 VKLLIEYGVNMHRFLTIGHLEELYNTKQGPTNLLLHHLVRDVKQSNPSPDYRISLIDVGLVIEYL 518

  Fly   609 MGGAYRSYYTRRKFRPIYAKVMNSY---------------------------------------- 633
            :||||||.|||:.||.:|..:...:
Frog   519 IGGAYRSSYTRKSFRVLYNSLFRKHKKSVPSSSSSLAQSLSHLSINQSSQMSSKLESPESTLHSQ 583

  Fly   634 ----ANAC-RKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLM 693
                |..| ||..|..:|:....:.::...     .:|...|.:|:|:||:||||.|||:||:..
Frog   584 FFRTAQPCRRKDKTTCHQKSKKKDEVTCTE-----DNEPVGFIYPYNDLLVWAVLMKRQKMAMFF 643

  Fly   694 WTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQ 758
            |.|||||:.|::::||||:||||||.:..:..:..|||:.|:|||......:|:.:::.:.:.|.
Frog   644 WQHGEEAMVKAVIACKLYRAMAHEAKQSTMVDDTSEELKKYSKEFGQLALDILENAFKMNEQMAM 708

  Fly   759 RLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYI 823
            :|||.:|.:|||.:||.|||::..|..::|.|:|::|.|:|||.|:.||::..|||||:.:|.::
Frog   709 KLLTYQLKNWSNSTCLKLAVSSTLRPFVSHTCTQMLLTDMWMGRLKMRKHSWLKVILGILLPPFV 773

  Fly   824 RQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDS 888
            ..|:||:|.|:..:||:.|.|                ....|..|..|:...:.|      :||.
Frog   774 LMLEFKTKAEMSHVPQSLEFH----------------QFSRLYVDPPSLSTKEEH------ITDF 816

  Fly   889 DTAQFREFFNLSEYNEVKQHQP-------LRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTV 946
            |..:.      |:.....|:|.       |.:.:|..|||:|||.|||..::.|:.||::|::||
Frog   817 DAERG------SKQPGEDQNQKISNGLGILPITRKICEFYSAPIVKFWFHTMVYLAFLMLFTYTV 875

  Fly   947 LVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGL 1011
            ||||:..|..|||..|.||.|...|||||:..|||...:.|..||....||..|..||.||.||.
Frog   876 LVKMDPQPSVQEWCVIIYIFTTAVEKVREVFVSEPGKFSQKVKVWINEYWNLTDSIAIFLFFIGF 940

  Fly  1012 AFRFRENTMD-IGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMS 1075
            ..|:.:.... .||:|||:|.|:||:|:|:...||:..||.:||:|||..||...|:::|:||::
Frog   941 GLRWPDPPFQTAGRIIYCLDIIFWYVRLLDFFAVNQQAGPYITMLGKMTSNMFGIVIIMAIVLLA 1005

  Fly  1076 FGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMS 1140
            |||||:|||.|:..|:|:|.:::.||||:|::|||:||:|| .|.|||.   |..|.::||...:
Frog  1006 FGVSRKAILSPDHPPSWTLARDIVFQPYWMMFGEVYAGEID-ACEEDPD---CPPGSFITPFLQA 1066

  Fly  1141 MYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLK 1205
            :||.:..|:::||||::|||::..:|||||::|.:.|:..:|.|.:||.||||.|.|.|.|.|:.
Frog  1067 VYLFVQYIIMVNLLISLFNNVYRVLNSVSHKLWKYNRYRYIMTYYEKPWLPPPLIFLSHIYILIN 1131

  Fly  1206 YCVRKAKGLEV---QRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTER 1267
            .........|.   :.|.||||:|..::|.:|:||||:|||.:|||:...|:.|.:||::.||||
Frog  1132 RLCHHRSHSEFDPEETDMGLKLYLSDNELRKLHDFEEKCVETYFHEKNESLHSSKNERIRVTTER 1196

  Fly  1268 VETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRF--MSTHTAGADDLRGS 1330
            .|.|..:::::|.|......::.:::.:|..:::.|...:..|.:|...  :....|...|.:|.
Frog  1197 TEEMFAQLKEVNDKVFYIKDSLSSLDSQLGHLQDLSALTVDTLKIISAVDSLQVEEAFIKDKKGL 1261

  Fly  1331 TI--------NIP-GEMQR-----------MRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGA 1375
            |.        |:| ...||           :||::.|...
Frog  1262 TCKKLPHSWSNVPYSHHQREYNYYSMPPSLLRTLARSQCP------------------------- 1301

  Fly  1376 GLNLNSL------QVTTRRRFNRS---------LTEVRP-DAYIFDEGTHFEVVPL--PEEP--- 1419
                 ||      |:|.:...:.|         :|...| |:.......::.:||.  |..|
Frog  1302 -----SLYQCPPQQLTAQLEIHNSEEPKIEVDIVTMAVPLDSKSAQHYGNYLLVPSVGPPAPTDS 1361

  Fly  1420 ------DEVVKSREALNEQVVRKASMQSEADSDIYIPVSQRPSTCETVKRTPYVTVRQDTGASTE 1478
                  .:::...||::.|...|..:.| ..||..:...|:     .||.:...|:::|
Frog  1362 AFKETCSDMLSEGEAISVQATTKERICS-IHSDQCLCSKQK-----HVKESSRKTMKED------ 1414

  Fly  1479 SKDTLTPMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLT---GADI 1540
                |.|:..|.|:..   .:.|.:.:.|            |.|..:....|.|.::.   |..:
Frog  1415 ----LKPLVTNTDESQ---NEESHECSCD------------QFTAHVTVETSITCNIIDPGGGYV 1460

  Fly  1541 NRSHISLNQLASLSRRQMSLTQSEPDSDKDAPIAQGSAHPGKSVLHAKPSR-NILLKLHSEYTSI 1604
            |.:.....:.|..|........|.|...     ::.:..|.||    ..|| |...:..|.|...
Frog  1461 NLAFSEEGETALFSGGSSKTLCSRPTQS-----SKSNVFPNKS----DGSRANDRPEFGSGYKQK 1516

  Fly  1605 TDELESVCHMIASPTVSLPSNKASLDRPKTEMSRAEAAALLEKKHLKECEENDY-------MILE 1662
            |..|::..:...||..|...:|                   |||..|.|...|:       .:..
Frog  1517 TSFLKNSLYRNNSPRGSSKRHK-------------------EKKDGKICTIKDFAKPPESSKVTW 1562

  Fly  1663 GLIESRGSIDASAQGFEIGVSIDYSHRYPLRRETAVELSPSKPSVDG---DLMGGGEGGGAGGGD 1724
            ...:.|.:...|.:.                :....:|.....:|||   ......|....|...
Frog  1563 AKEKLRSTFRKSVKD----------------KPRPTQLQVPVITVDGCSQSTQMSSEPADCGSWK 1611

  Fly  1725 SSDTSGAGSCGAMVGISSGFQLKNERPWQRNSSMEQQTYPSPLVPTRATSDFLNPPYE------- 1782
            |.|.....    .:.:||..||..:........::.|.:...||   .||::|....|
Frog  1612 SEDEPSKN----RLTVSSFNQLSLDHMTYMRQQLKTQEFERHLV---QTSEYLRQSREDLHNTTQ 1669

  Fly  1783 ---GRLFKKSSE------SLQKNSSTETDYSA 1805
               ..||:.|.|      ||:.:......|||
Frog  1670 LRRSSLFRNSDEVKKMAASLKASQDLSNHYSA 1701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	97/216 (45%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	11/50 (22%)
trpm6	XP_031746734.1	LSDAT_euk	105..370	CDD:407971	132/268 (49%)
		trp	<724..1119	CDD:273311	172/426 (40%)
		TRPM_tetra	1187..1241	CDD:406826	13/53 (25%)
		Alpha_kinase_ChaK2_TRPM6	1725..1963	CDD:341222
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	408	1.000	Domainoid score	I685
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1172	1.000	Inparanoid score	I201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48134
Panther	1	1.100	-	-	O	PTHR13800
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X538
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070