Protein Alignment Trpm and trpm7

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_002939674.2
• Gene: trpm7 / 100329113
• XenbaseID: XB-GENE-486884
• Length: 1875
• Species: Xenopus tropicalis
• Alignment Length: 1805
• Identity: 631/1805 - (34%)
• Similarity: 928/1805 - (51%)
• Gaps: 309/1805 - (17%)

  Fly    39 RSWIETNFQKRECIKFIPCPKDD-------------TKCCCGQAQITHQTIPGIESGSPGDL--- 87
            :||||.:|.||||...||..||.             .:||||:....|.......:....|:
 Frog     5 KSWIENSFTKRECTYIIPSSKDPHRCLPGCQICQQLVRCCCGRLVRQHACFTASVATKYSDVKLG 69

  Fly    88 ---------WLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELP 143
                     |...|||...||||||.|.||||:|..:|:|||||:|::||.::||..|||.:|||
 Frog    70 EQFNEELEEWSVEKHTEESPTDAYGVINFQGGSHSYRAKYVRLSYDSKPEAILQLMLKEWQMELP 134

  Fly   144 KLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGR 208
            ||:|:|.||...|:|..::|:.|.|||:|||.||||||.|||.|.||.|.|||||.....:.:.:
 Frog   135 KLVISVHGGMQKFELHPRIKQLIGKGLIKAAVTTGAWILTGGVNAGVAKHVGDALKEHASRSSRK 199

  Fly   209 VVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILR 273
            :.:|||||||::|..::|:|.:...|..::.:|.|||.||||.|::|:|||:||..|||||:.||
 Frog   200 ICTIGIAPWGVIENRNDLIGRDVIAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVNLR 264

  Fly   274 RKLEKFISNLKLHPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSG 338
            |:|||.|:..::|..         .....|||.|:.|||.|.|..||||:.:|||||||||:|:|
 Frog   265 RELEKTINLQRIHAR---------IGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTG 320

  Fly   339 RAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFR 403
            ||||:||:|||...:|...|  |.....:|.||:|||.....::..|:|..::|.::|.|||||.
 Frog   321 RAADILAYVHKQTEEGGTLP--EGADLEIISTIKKTFNFSQSEAIHLFQTTMECMKSKELITVFH 383

  Fly   404 IQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMM 468
            |   ...|.|::|..|||||.|..:.|..:||.|.|.|:|||||::.:|||||:|..|:|::||:
 Frog   384 I---GSDEHQDIDVAILTALLKGTNASALDQLVLTLAWDRVDIAKNHVFVYGQQWLVGSLEQAML 445

  Fly   469 QALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPAN-TLGYILRDVRP-HIPKGYIYTL 531
            .||..||:.|||||:||||||.|||||||||||||||.||.| ||.:::|||:. ::|.||..||
 Frog   446 DALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPTLFHLVRDVKQGNLPPGYKITL 510

  Fly   532 HDIGLVINKLMGGAYRSYYTRRKFRPIYAKVM---------------------NSYANACRKSST 575
            .|:||||..||||.||..|||::||.||..:.                     .|:.|...|...
 Frog   511 IDVGLVIEFLMGGTYRCTYTRKRFRIIYNNIQGGNRRSGRNTSSNTPQMRKSHESFGNRADKKEK 575

  Fly   576 YQY-------QRYAGANSLSLVTGLLPFTS---------EMALFEFPFNELLIWAVLTKRQQMAL 624
            .::       |.|.....:|...|....|.         ||..|::||||||:|:||.|||:|||
 Frog   576 MRHNHFIKTAQPYKPKQDVSADDGKKKKTKEEIVDIDDPEMKRFQYPFNELLVWSVLMKRQKMAL 640

  Fly   625 LMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEK 689
            ..|.||||::||:||:|||.:.||:||.:.|:..||.||.:.::.||......|||.::|||...
 Frog   641 FFWQHGEESMAKALVACKLCRTMAYEAKQSDVVDEIAEEFKEHSSEFGQLAVDLLDQAFRQDETM 705

  Fly   690 AQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPF 754
            |.:|||.||.:|||.:||.|||::..|..:||.|:|::|:|:|||.|..|||:.:||||.:.:|.
 Frog   706 AMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPP 770

  Fly   755 YIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRS-QPDAESALLKAKRSISLRYRMGAGANN 818
            .|..|::|:|.|:..:||:::.    ..:..|||:.: |...|:..:...|.:
 Frog   771 TILMLEYKTKAEMSHIPQSQDA----LQMTMDDSENNFQNLPENIAMNVFREV------------ 819

  Fly   819 RDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVK-QHQP--LRLKKKFYEFYT 880
                                             |.|..:...:|:: |.:|  |.:.:|||.||.
 Frog   820 ---------------------------------RPFDTMEVKHEIETQAKPRKLPITQKFYAFYH 851

  Fly   881 APITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHK 945
            |||.|||.:::.|:.||::|::.||||||.:|..|||..|:||.|...||:|||..||...|..|
 Frog   852 APIVKFWFNTLFYLGFLMLFTYVVLVKMESLPSVQEWIVISYIFTSAVEKIREIFMSEAGKINQK 916

  Fly   946 FSVWAWNMWNPCDGAAIILFVIGLAFR----------------FRENTMDIGRVIYCVDSIYWYL 994
            ..||..:.:|..|..|||.|.||...|                :.|.....||:.||::.|:||:
 Frog   917 VKVWFGDYFNITDTIAIITFFIGCGLRLGAYRDVPEDQLKDDEYNETISLAGRLTYCLNIIFWYV 981

  Fly   995 RILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIAG 1059
            |:|:.|.||:..||.|.|:||||.||.|.||::||||:||||.|||||||:::|:|.|.::::
 Frog   982 RLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMAVVLLSFGVPRQAILYPHQEPSWRLARDIV-- 1044

  Fly  1060 SITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLT 1124
                                                                             
 Frog  1045 ----------------------------------------------------------------- 1044

  Fly  1125 SGNLTNVTFQPYFMLYGEVFAGDIDPPCGEDPSQPG-CVTGHWVTPITMSMYLLIANILLINLLI 1188
                    ||||:|::|||:|.:|| .|..:...|. |..|.|:||...::||.:..|:::||||
 Frog  1045 --------FQPYWMIFGEVYAYEID-VCANNSEVPDLCDVGTWLTPFLQAVYLFVQYIIMVNLLI 1100

  Fly  1189 AVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKY-CVRKAKGLEVQRD 1252
            |.|||::.||.::||.||.:||:..:|.|.:|||||||.|.|.|..||..: |.|:.|.   :..
 Frog  1101 AFFNNVYFEVKAISHIVWKYQRYHFIMAYHEKPVLPPPLIILSHLASLFGFVCKRRKKD---KTS 1162

  Fly  1253 NGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENI 1317
            :|.||||.::|.::|:||||:|||.:|:|::...:..::||::.|:||||.|..:|:::..:.|.
 Frog  1163 HGPKLFLTEEDQKKLHDFEEQCVETYFNEKDDKFHLGSEERIRVTSERVEQMCIQIKEVGDRVNY 1227

  Fly  1318 QTATVQNIEFRLRKMEESS-----------EQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEM 1371
            ...::.:::.::..:::.|           .|..|..:.:|..::...:.:..| |.|:...|.:
 Frog  1228 IKRSLHSLDTQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHL-GQTVVDDGPL 1291

  Fly  1372 QRMR-TISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTR-----RRFNRSLTEV 1430
            :.:| ..|:.:..|.|.|.||  .......|..:.|....|..|.:....     ||.|.::.|.
 Frog  1292 RSLRKKHSVGNFFGSSFPQGN--QESNSNLIFNISLRNERNSQSRKTGDEFCFPYRRENLNIPEA 1354

  Fly  1431 RPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSEADS-----DIYIPVSQRPST 1490
            .|.....   .|.:  ..|.:..|..:..|:|.:..:......||.:|     ..::....:|::
 Frog  1355 GPSGSAL---LHSK--DCPTDAMENTEGTESLTDNQIVDNVASSEPNSVSGMATFFVSTPTQPNS 1414

  Fly  1491 CETVKRTPYVT--VRQDTGASTESKDTLTPMGNNDD----DQTLVGGDNSDDATPDINFEAARHR 1549
            ...::..|.:.  :.|......||.:....:|:.|:    ......|.:.::|.......|....
 Frog  1415 ASQLELEPKMEKYINQRAAREAESIEFGAFVGHRDNVILHKYKEPEGKSKEEAKATDVVVAPALP 1479

  Fly  1550 ALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMSLTQSEPDSDKDAPIAQGSAHPG 1614
            :|:|  |..|....:.     :.|:||. .||:|.|.|||......|..:..|:|.:........
 Frog  1480 SLKQ--VRSCAGFMDL-----STISRSS-QLNKLHSSSRRASLTEDSNLEETKEAFLTNWLQAHS 1536

  Fly  1615 KSVLHAKP--------------------------SRNILLKLHSE--YTSI--TDELESVCHMIA 1649
            .|...|||                          .||.|::|...  :|.:  ..||.:|..:..
 Frog  1537 SSTSKAKPPEDDAFNAIGSPFKPIVDINYCYSAVERNNLMRLAQSIPFTPVPPKGELVTVYRLEE 1601

  Fly  1650 SPTVSLPSNKASLDR----PKTE-MSRAEAAALLEKKHLKEC--EENDYM 1692
            |....|.::.:|..:    .|.| :|:.|....|.:.....|  .|||.:
 Frog  1602 SSPNMLNNSMSSWSQRGLCAKIEFLSKEEMGGGLRRAVKVVCTWSENDIL 1651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	134/275 (49%)
		TRPV	<872..1227	CDD:454755	138/371 (37%)
		TRPM_tetra	1291..1346	CDD:465156	13/65 (20%)
trpm7	XP_002939674.2	LSDAT_euk	107..372	CDD:465665	134/275 (49%)
		TRPV	<672..1174	CDD:454755	216/629 (34%)
		TRPM_tetra	1201..1256	CDD:465156	11/54 (20%)
		Alpha_kinase_ChaK1_TRMP7	1592..1830	CDD:341221	15/60 (25%)