Protein Alignment Trpm and trpm8b

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_012825655.2
• Gene: trpm8b / 100302009
• XenbaseID: XB-GENE-12442826
• Length: 1090
• Species: Xenopus tropicalis
• Alignment Length: 1327
• Identity: 335/1327 - (25%)
• Similarity: 561/1327 - (42%)
• Gaps: 316/1327 - (23%)

  Fly    45 NFQKRECIKFIPCP-KDDTKCCCGQAQITHQTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQ 108
            :.:|||||.|...| ..::.|.||  .:..|...|::: :..|.|..|:||:...|||||.|:|:
 Frog    39 DIKKRECIVFTQDPSSQESLCKCG--YLKRQHTEGVQT-NQNDRWNYTRHTKELSTDAYGEIQFE 100

  Fly   109 GGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKA 173
              ....:|:|:|||.||.|.:|.:|.|..|.|:.|.|:|:|.||..||.|:.:::|.||: |:..
 Frog   101 --TFGRRAKYIRLSRDTAPAILYKLMTSYWQLKTPNLIISVTGGARNFSLKPRIRKIIRR-LIYI 162

  Fly   174 AKTTGAWIFTGGTNTGVTKQVGDALL--LEGQQRTGRVVSIGIAPWGIVERNHELL---GHNREV 233
            |::.|||||||||:.|:||.:|:.:.  ...|...|:|.:||||.||::.....|:   ....:.
 Frog   163 AQSKGAWIFTGGTHNGLTKYIGEVVRDNTISQSSEGKVAAIGIAAWGMISNRDSLIRSPDDEGKY 227

  Fly   234 PCHSISSPRSK--LAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPSKNHWLKTN 296
            ..|.:...:.:  |..|:|.|.:|:|||||:......|..||..||..||.|.. |..::
 Frog   228 IAHYVMDEKKEDGLYCLDNNHTHFILVDNGSHKHPTIEAELRASLEGCISELTA-PDSDY----- 286

  Fly   297 VTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQP--- 358
              ....|:||.|..||..|::|:...:...  :|.||.:|||:.||::|.:  ..::|...|
 Frog   287 --SGKIPIVCFVHSGGKETLKAINRAIKSK--IPCVVVEGSGQIADVIASL--VETEGTSVPSTI 345

  Fly   359 VLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTAL 423
            :.|.|..:|..|:.:..|   |:.|...|.:.:...:.||:||.:|.|..:   :.:...|..||
 Frog   346 IKEKMLHFLKYTVSRLTE---DELEAWIQWIKEIMESPNLLTVIKIDEAGD---ETVSDAISAAL 404

  Fly   424 FKSQHLSPPE------QLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLL 482
            :|:......:      ||.|.|.||::::|.:|:|..||.|....|::||..||..||.:||:||
 Frog   405 YKAYSTRELDKGNWNAQLKLLLEWNQLELANNELFANGQHWKTADLEDAMFTALVKDRPEFVRLL 469

  Fly   483 LENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDVRPHIPKGYIYTLHDIGLVINKLMGGAYR 547
            ||||:.:.|||:...|.:|::                 .|.......:|.......|.|:...:|
 Frog   470 LENGLDLDKFLSSEVLRQLFS-----------------EHFSTHAFKSLEMADKSYNPLLTFVWR 517

  Fly   548 SYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLI 612
            ....   ::|...:..|        ||.|:.|     |..||:.            ..|...|.|
 Frog   518 MVLV---YQPSNKEKWN--------SSDYKIQ-----NISSLIK------------RHPTQVLFI 554

  Fly   613 WAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNK 677
            ||:|..:::::.::|...:.....:|.:.||.|.:    |:.:.|.:..:|....|.|:|::...
 Frog   555 WAILQNKRELSTVIWEQTKACTLAALGASKLLKHL----AKVNKDIKTAQESEEMAHEYETRAVD 615

  Fly   678 LLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNT 742
            |....|..|.:.|..||.....:|...:||.:|||||.:..:|.|..|..|:..|.|.: :|...
 Frog   616 LFTECYSNDKKLAGMLLVHSCEAWGKSNCLDMAVAANDQQFIAQPGVQNFLSKQWYGAI-SRDTK 679

  Fly   743 NFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAESALLKAKRSIS 807
            .:|::|.|    :|..|                                              ||
 Frog   680 TWKILLSL----FIFPL----------------------------------------------IS 694

  Fly   808 LRYRMGAGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLK 872
            ..:......:||.::.|
 Frog   695 CGFITFRNISNRKRSRL------------------------------------------------ 711

  Fly   873 KKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISS 937
            .|:.:|:|:|...|....|.|:.||.:|::.:|:..:.:|...|......:..|...::|::|.|
 Frog   712 WKYCDFFTSPFVVFSWTVIFYIGFLFLFAYVLLMDFQPIPTGLEIVVYLLVFILLCIEIRQMIIS 776

  Fly   938 EPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRE---NTMDIGRVIYCVDSIYWYLRILNI 999
            .        :.::.:.||..|..||:.|::|:.||.:.   :.:.:||||.|:|.|.:.||::.|
 Frog   777 R--------AEYSRDCWNIMDCMAILYFIVGVLFRLQNSNPSALYVGRVILCLDYIIFTLRLIQI 833

  Fly  1000 LGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIAGSITAP 1064
            ..:::.|||.:.|:.:|..::.:|:.|.||.:::|||:.|.||..|:. .|..|
 Frog   834 FTISQNLGPKIIMLQRMFVDVFFFLFLFAVWIVAFGVANQGILRLNEH-RWEWI----------- 886

  Fly  1065 GFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGNLT 1129
                                                                           ..
 Frog   887 ---------------------------------------------------------------FR 888

  Fly  1130 NVTFQPYFMLYGEVFAGDID-----------------PPCGEDPSQPGCVTGHWVTPITMSMYLL 1177
            :|.:|||..::|..|: |:|                 |.|.|..|:.......|:|...:|:|:|
 Frog   889 SVIYQPYLAMFGGPFS-DVDEATYDFDKCTITGNESKPLCVEVDSENNPRFPEWITIPLVSVYML 952

  Fly  1178 IANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFY----SLLK 1238
            ..||||:|||||:|......|...:.|||.|||:.:|.||..:..:|.||:...:.|    :|..
 Frog   953 STNILLVNLLIAMFGYTVGSVQDNNEQVWKFQRYFLVQEYCSRITIPFPFVIFGYIYLIMRNLFS 1017

  Fly  1239 YCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVET 1303
            :|.:|      |....|.....|:|.:.|      ..|....|..::...|..:..:....|.:.
 Frog  1018 WCYKK------QEPPPLPCCFNKEDNKTL------AWEAVMKENYLVKKISETQNNREMEHRFKQ 1070

  Fly  1304 MSQKIEDINQKENIQTATVQNIEFRLR 1330
            :..|:.:::       :.|.::..|::
 Frog  1071 LEGKLNELH-------SLVMDLTVRIK 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	97/285 (34%)
		TRPV	<872..1227	CDD:454755	92/374 (25%)
		TRPM_tetra	1291..1346	CDD:465156	4/40 (10%)
trpm8b	XP_012825655.2	LSDAT_euk	106..378	CDD:476852	97/287 (34%)
		TRPV	<577..1043	CDD:454755	144/664 (22%)