Protein Alignment Trpm and trpm2

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_031749423.1
• Gene: trpm2 / 100124999
• XenbaseID: XB-GENE-996775
• Length: 1491
• Species: Xenopus tropicalis
• Alignment Length: 1739
• Identity: 469/1739 - (26%)
• Similarity: 748/1739 - (43%)
• Gaps: 355/1739 - (20%)

  Fly    40 SWIETNFQKRECIKFI--PCPKDDTK--CCCGQAQITHQTI---PGIESGSPGDLWLPTKHTRPQ 97
            |||..|.:|:||:.|:  ||..|..|  |.||..:..|..:   |  :|.....||...:|.:..
 Frog    52 SWISENIKKKECVYFVKNPCISDLRKNVCMCGYTKDQHMDMAIRP--QSFESKVLWDFKEHIKEV 114

  Fly    98 PTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKL 162
            ||||:|.|.|.|.......||||:|.||..::|.||.|:.|.||:|.|||:|.||..||.:|.:|
 Frog   115 PTDAFGDISFIGLGPRVGKQYVRVSSDTPSDVLYQLMTEHWGLEVPSLLISVTGGAKNFRMQMRL 179

  Fly   163 KKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDAL--LLEGQQRTGRVVSIGIAPWGIVERNHE 225
            |...|:||:|||:||||||.|||::.||.||||:|:  ...|..:...:|:||||.||||.....
 Frog   180 KNIFRRGLVKAAQTTGAWIITGGSHAGVMKQVGEAVRDYSFGSIKDSEIVTIGIATWGIVHNRRS 244

  Fly   226 LLGHNREVPCHSI--SSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPS 288
            |:......|...:  ...:..|:.|:|.|::|:|||:||..|||.|::||.|||||||.....
 Frog   245 LISATGAFPADYLLEEENQGNLSCLDNNHSHFILVDDGTNGKYGVEILLRAKLEKFISEQTTE-- 307

  Fly   289 KNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFV-HKYAS 352
                 |..|. ...|:||:|:|||..|:..:...:.::  .|.|:.:||||.||::|.| |...|
 Frog   308 -----KGGVA-IKIPIVCVVLEGGPGTLDTIYNAIRNN--TPCVIVEGSGRVADVIAQVAHLPIS 364

  Fly   353 DGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQ 417
            ......:.|.:|.....|.....|..:....|..|:::   ||..|:|:|::.   :.:..::|.
 Frog   365 KITISLIQEKIRTLFPDTFDTFTEYKIADWTKKIQDIM---RNNQLLTIFQVD---KDDQHDIDF 423

  Fly   418 TILTALFKSQ-------HLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDR 475
            .||.||.|:.       |.:...||.||:.||||||||||||....:|....|...|..||..::
 Frog   424 AILQALLKASLSHDQQGHENWDHQLKLAVAWNRVDIARSEIFTDELQWKPSDLHPLMTAALIGNK 488

  Fly   476 IDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPA----NTLGYILRD--VRPHIPKGYIYTLHDI 534
            .|||||.||.||.::::.|...:..|||.. .|:    :.|..:..|  :|....|.:...||.:
 Frog   489 PDFVKLFLEQGVRLEEYATQETIINLYNNT-DPSCLFHSKLAKVFEDERLRLETSKSFKLQLHHV 552

  Fly   535 GLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSL---VTGLLPF 596
            ..|:.:|.|.     :|:.    :|.|..||...:...:..:......|....|.   ..|..|.
 Frog   553 SQVLRELFGD-----FTKH----LYPKPKNSEKPSVSIAVPHMKINVQGVTLRSFHKRSQGRAPC 608

  Fly   597 TSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIY 661
            |.:      |..:||||.|:..|:::|.::|:...:.:|.:|...||.|.::.|  |:|.||.
 Frog   609 TMD------PIRDLLIWCVVQNRKEVAEIIWSQCHDCIAAALACSKLLKELSKE--EEDTDTS-- 663

  Fly   662 EELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQV 726
            ||:.:.|:|||.:...:....||:|.|:|.:||.....:|...:.|.||:.|.....::|...|.
 Frog   664 EEMLALAEEFEQRAIGIFTECYRKDEERALKLLIRVSEAWGKTTSLKLALEAKDMKFVSHGGVQA 728

  Fly   727 ILADLWMGGLRTRKNTNFKVILGLAMP-FYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDR 790
            .|..:|.|.|.........:|..|..| .|.|.:.|                            |
 Frog   729 FLTRVWWGELCVDNGIWRVIICMLFFPLIYTRFITF----------------------------R 765

  Fly   791 SQPDAESALLKAKRSISLRYRMGAGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFF 855
            :.|.|.                        |.:.|.|:|
 Frog   766 TTPCAA------------------------KKMQATTFS-------------------------- 780

  Fly   856 NLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSI 920
                             ::...|:.|||..|..:.::|..||::|::.:::..:..|.|:|....
 Frog   781 -----------------ERLQAFFMAPIVIFHLNILSYFGFLLLFAYVLMINFQPFPSWRELVIY 828

  Fly   921 AYITTLGFEKVREII-SSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDIGRVI 984
            .::.:...|:||::: ..:......:.|::..:.||..|..|||:|::||..|.:..|:..||:|
 Frog   829 VWLFSFVCEEVRQVVYDPDGFGFLRQASIYINDFWNKLDLCAIIIFIVGLICRSQPATLYSGRII 893

  Fly   985 YCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNK-QP 1048
            ..:|.:.:.||:::|..::|.|||.:.::.:|:|::.:|:.||||.::||||::||||..|: :.
 Frog   894 LSLDFVIFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNEVRV 958

  Fly  1049 TWSLIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTM-GAPPVTTTAASTTTGSSSTVPAATTST 1112
            .|.              |.|.:.|:        |.|: |..|      |...|.:.:....|.:.
 Frog   959 DWI--------------FRGVVYHS--------YMTLFGQIP------SYIDGVNYSPDQCTLNG 995

  Fly  1113 TAPIHNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLL 1177
            |.|      |......||.|.||.|                          ..|:|.|.:..|||
 Frog   996 TDP------NKQKCPETNETNQPVF--------------------------PQWLTVILLCFYLL 1028

  Fly  1178 IANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVR 1242
            ..||||:|||||:||..|.:|...:.|:|.|||..::.||..:|..|||||...|.|..:|..:.
 Frog  1029 FTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPPAPPPFILCSHMYLFIKQVIL 1093

  Fly  1243 KAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQK 1307
            ......:::   ||..|||::...|..:|....|.:....:....||||:|:|:|:|:|.::.:.
 Frog  1094 HEPAGRLKQ---LKEKLEKNEEAALLSWETYLKENYLQNYQHFQKQSTDQRIKDTSEKVASVLEM 1155

  Fly  1308 IEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQ 1372
            :| :.|.:  :|..::|   ||..:||.:.:....|..|...:..:..|:.|.....::     .
 Frog  1156 LE-LEQAK--RTGLMEN---RLLFLEEQALRSAKALNWIVNTLLENGFGSKDSAPVIVS-----S 1209

  Fly  1373 RMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVR---PDA 1434
            :.....:.|||.                 |.:         ...|..|..:......:|   ||.
 Frog  1210 KFNVTDLGDTED-----------------VKI---------QTHVIARNIWYPDSNIIRFPVPDE 1248

  Fly  1435 YIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSEADSDIYIPVSQRPSTCETVKRTPY 1499
            .:..| .||::...|             ....|||       |...|.|.:   .:.:.:.:..|
 Frog  1249 KVSWE-VHFKIYNPP-------------FYTAVRK-------DKKYYDPFN---DSMQALSKISY 1289

  Fly  1500 VTV-----RQDTGASTESKDTL--TPMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVS 1557
            .|:     ||...|:.|.||.|  .|:|...    |.|..:.....|:....:...:..|.:..|
 Frog  1290 NTMDGNINRQSFCATYEVKDGLPMNPVGRTG----LKGRGSLCWFGPNHALHSIITKLRRNKDGS 1350

  Fly  1558 LCRRNSETYSLTGADINRSHISLNQLASLSRRQMSLTQSEPDSDKDAPIAQGSAHPGKSVLHAKP 1622
            :||:             ||...|..|...|:                 :::..|.||.|:   :|
 Frog  1351 ICRK-------------RSKKMLETLVIKSK-----------------LSENWALPGGSM---EP 1382

  Fly  1623 SRNILLKLHSEYTSITDELESVCHMIASPTVSLPSNKASLDRPK-TEMSRAEAAAL------LEK 1680
            ...:..||.....|  |.|.:...|:..   .:...|..:|.|: |:.:..|..|:      |:.
 Frog  1383 GEALPYKLRKILKS--DFLSTFQSMLKK---GIEVYKGYVDDPRNTDNAWIETTAVSLHFDNLDD 1442

  Fly  1681 KHLKECEEN------DYMILEGLIESRGSIDASAQGFEIGVSIDYSHRY 1723
            ..|...|:|      |..:...:::.:..:.|:.:.. :..::||.|.|
 Frog  1443 LQLYALEQNLQIHHQDIFVRWQVVDQKIPLYANHKDI-LQKAVDYHHAY 1490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	111/280 (40%)
		TRPV	<872..1227	CDD:454755	103/357 (29%)
		TRPM_tetra	1291..1346	CDD:465156	15/54 (28%)
trpm2	XP_031749423.1	LSDAT_euk	134..356	CDD:476852	101/231 (44%)
		TRPV	<709..1086	CDD:454755	130/531 (24%)
		NUDIX_ADPRase_Nudt9	1314..1487	CDD:467538	38/215 (18%)