DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scb and ITGAX

DIOPT Version :10

Sequence 1:NP_523750.2 Gene:scb / 36692 FlyBaseID:FBgn0286785 Length:1115 Species:Drosophila melanogaster
Sequence 2:NP_001273304.1 Gene:ITGAX / 3687 HGNCID:6152 Length:1169 Species:Homo sapiens


Alignment Length:1323 Identity:258/1323 - (19%)
Similarity:425/1323 - (32%) Gaps:472/1323 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 SSYFGYTLVIRQTS-IIVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYS 113
            |:.||.::|....| ::||||      :.....|:||.:|:|..:.|.|.|.      .:..|..
Human    34 SAGFGDSVVQYANSWVVVGAP------QKITAANQTGGLYQCGYSTGACEPI------GLQVPPE 86

  Fly   114 EYTFDSERKDFQWLGGSMDGGTKDTDKLLVCAPRFYAPSSRDNHLHGVCY--------------- 163
            .....        ||.|: ..|....:||.|.|..:....|:.:|.|:|:               
Human    87 AVNMS--------LGLSL-ASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSR 142

  Fly   164 ----------------------------------------------------------------- 163
                                                                             
Human   143 QECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFR 207

  Fly   164 ----------------------------------------------------------------- 163
                                                                             
Human   208 RSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDV 272

  Fly   164 -------------------------WVN-NTVASTP--QHVTRI---SPLRLKSEQVKEE----- 192
                                     |.. |.:||.|  :|:.::   ..|:....|:||:     
Human   273 IPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIE 337

  Fly   193 --DNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSK 255
              :..:.:||...|.:.|.||....|..  ::||.|..||.|...||   .|..:||        
Human   338 GTETTSSSSFELEMAQEGFSAVFTPDGP--VLGAVGSFTWSGGAFLY---PPNMSPT-------- 389

  Fly   256 ALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANK 320
            .:..:..:||.                     .|||.||:.....:.....    .|..||: .:
Human   390 FINMSQENVDM---------------------RDSYLGYSTELALWKGVQS----LVLGAPR-YQ 428

  Fly   321 QSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAI 385
            .:|:|.||....:.........|.|.|.|||.|:.:.|::.||.||:::....|..|.:......
Human   429 HTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVS 493

  Fly   386 YVFINKGFFNF--ERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAP--FAGNGTVFIYLG 446
            ...:.:|:..:  :..:.........|||.||:.|||:|.|...||.:|||  ....|.|:::.|
Human   494 VCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHG 558

  Fly   447 SEN-GLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPV 510
            ... .:....|||: |.||..|:.  ..||..||.|.|:..:|..|.|:||..  .|.|.|..||
Human   559 VLGPSISPSHSQRI-AGSQLSSRL--QYFGQALSGGQDLTQDGLVDLAVGARG--QVLLLRTRPV 618

  Fly   511 VKVHATVK----------SESRE-IKPEQEKVKITACYRLSTTSTDKLVQEQELAIRIAMDKQL- 563
            :.|..:::          .|.|| :..||..|:...|..:...|.: |:..::|...:.:|..| 
Human   619 LWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKN-LLGSRDLQSSVTLDLALD 682

  Fly   564 -----KRVKFTQTQTNEISFKVNANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKK------ 617
                 .|..|.:|:...:|..........|.:|...:....:|..|||.|.:::.|..|      
Human   683 PGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFR 747

  Fly   618 ------VPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQLR-SKDVSPTYILGSA 674
                  ..|::.:              .|.::.|...|..| :|..:|.:. |.....:.::|| 
Human   748 NLRPMLAADAQRY--------------FTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGS- 797

  Fly   675 DTLRLNYEIT--NIGETAYLPQFNVTSTSRLAFAQVPGNCK---------VVDAVMV-------- 720
             .|.||.|:.  |.||.:|......:..:.|::..|....|         ..|:..|        
Human   798 -NLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWST 861

  Fly   721 -CDLN----RGRPLAKGDTDSVTISFDVS--QLSGQSLIIHAEVFSTGYEQN-PTDNRQTNVIGL 777
             |.:|    ||     |...:...:||||  .:.|..|::.|.|.|   |.| |..::.|..:.|
Human   862 SCRINHLIFRG-----GAQITFLATFDVSPKAVLGDRLLLTANVSS---ENNTPRTSKTTFQLEL 918

  Fly   778 -------------KEFTEIDASGGQTNSQIDLEHYSNSAE-----IVNNYEIKSNGPSVIEQLTV 824
                         ::||:             ..::|.|.|     .::.|::.:.|...: .:::
Human   919 PVKYAVYTVVSSHEQFTK-------------YLNFSESEEKESHVAMHRYQVNNLGQRDL-PVSI 969

  Fly   825 SFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLER 889
            :|::|:                 .|..:|.:    :.:::....|..|.....::....|..|  
Human   970 NFWVPV-----------------ELNQEAVW----MDVEVSHPQNPSLRCSSEKIAPPASDFL-- 1011

  Fly   890 TVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLS 954
                           .|: |...|||.|:   |...|.|.|:.:.:...|             |.
Human  1012 ---------------AHI-QKNPVLDCSI---AGCLRFRCDVPSFSVQEE-------------LD 1044

  Fly   955 DDFKGKLPVN--RTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEY 1017
            ...||.|...  |.|                              ::..|.:..|..|..|...|
Human  1045 FTLKGNLSFGWVRQI------------------------------LQKKVSVVSVAEITFDTSVY 1079

  Fly  1018 FVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKF 1082
            ..:           |...:|   .|.:...:.:..:...|..:|:.|.|||||||:.|:.:|||.
Human  1080 SQL-----------PGQEAF---MRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVLYKV 1130

  Fly  1083 GFFNRTKKDELDRLVQQNPVEPE 1105
            |||.|..|:.::....|  :.||
Human  1131 GFFKRQYKEMMEEANGQ--IAPE 1151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scbNP_523750.2 Int_alpha 51..103 CDD:214549 16/52 (31%)
FG-GAP 350..388 CDD:460357 10/37 (27%)
Int_alpha 409..459 CDD:214549 20/52 (38%)
Int_alpha 473..>515 CDD:214549 17/41 (41%)
Integrin_alpha2 509..829 CDD:462478 78/395 (20%)
ITGAXNP_001273304.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 23..78 16/49 (33%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 79..138 13/73 (18%)
vWA_integrins_alpha_subunit 150..325 CDD:238746 7/174 (4%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 340..391 18/63 (29%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 392..443 14/76 (18%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 444..504 15/59 (25%)
Int_alpha 454..504 CDD:214549 13/49 (27%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 507..565 18/57 (32%)
Int_alpha 517..>558 CDD:214549 17/40 (43%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 570..630 23/64 (36%)
Int_alpha 582..628 CDD:214549 17/47 (36%)
Integrin_alpha2 616..1032 CDD:462478 93/496 (19%)
Integrin_alpha 1129..1143 CDD:459778 6/13 (46%)
GFFKR motif 1131..1135 3/3 (100%)

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