DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and ITGAX

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001273304.1	Gene:	ITGAX / 3687	HGNCID:	6152	Length:	1169	Species:	Homo sapiens

Alignment Length:	1323	Identity:	258/1323 - (19%)
Similarity:	425/1323 - (32%)	Gaps:	472/1323 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SSYFGYTLVIRQTS-IIVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYS 113
            |:.||.::|....| ::||||      :.....|:||.:|:|..:.|.|.|.      .:..|..
Human    34 SAGFGDSVVQYANSWVVVGAP------QKITAANQTGGLYQCGYSTGACEPI------GLQVPPE 86

  Fly   114 EYTFDSERKDFQWLGGSMDGGTKDTDKLLVCAPRFYAPSSRDNHLHGVCY--------------- 163
            .....        ||.|: ..|....:||.|.|..:....|:.:|.|:|:
Human    87 AVNMS--------LGLSL-ASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSR 142

  Fly   164 ----------------------------------------------------------------- 163

Human   143 QECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFR 207

  Fly   164 ----------------------------------------------------------------- 163

Human   208 RSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDV 272

  Fly   164 -------------------------WVN-NTVASTP--QHVTRI---SPLRLKSEQVKEE----- 192
                                     |.. |.:||.|  :|:.::   ..|:....|:||:
Human   273 IPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIE 337

  Fly   193 --DNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSK 255
              :..:.:||...|.:.|.||....|..  ::||.|..||.|...||   .|..:||
Human   338 GTETTSSSSFELEMAQEGFSAVFTPDGP--VLGAVGSFTWSGGAFLY---PPNMSPT-------- 389

  Fly   256 ALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANK 320
            .:..:..:||.                     .|||.||:.....:.....    .|..||: .:
Human   390 FINMSQENVDM---------------------RDSYLGYSTELALWKGVQS----LVLGAPR-YQ 428

  Fly   321 QSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAI 385
            .:|:|.||....:.........|.|.|.|||.|:.:.|::.||.||:::....|..|.:......
Human   429 HTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVS 493

  Fly   386 YVFINKGFFNF--ERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAP--FAGNGTVFIYLG 446
            ...:.:|:..:  :..:.........|||.||:.|||:|.|...||.:|||  ....|.|:::.|
Human   494 VCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHG 558

  Fly   447 SEN-GLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPV 510
            ... .:....|||: |.||..|:.  ..||..||.|.|:..:|..|.|:||..  .|.|.|..||
Human   559 VLGPSISPSHSQRI-AGSQLSSRL--QYFGQALSGGQDLTQDGLVDLAVGARG--QVLLLRTRPV 618

  Fly   511 VKVHATVK----------SESRE-IKPEQEKVKITACYRLSTTSTDKLVQEQELAIRIAMDKQL- 563
            :.|..:::          .|.|| :..||..|:...|..:...|.: |:..::|...:.:|..|
Human   619 LWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKN-LLGSRDLQSSVTLDLALD 682

  Fly   564 -----KRVKFTQTQTNEISFKVNANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKK------ 617
                 .|..|.:|:...:|..........|.:|...:....:|..|||.|.:::.|..|
Human   683 PGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFR 747

  Fly   618 ------VPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQLR-SKDVSPTYILGSA 674
                  ..|::.:              .|.::.|...|..| :|..:|.:. |.....:.::||
Human   748 NLRPMLAADAQRY--------------FTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGS- 797

  Fly   675 DTLRLNYEIT--NIGETAYLPQFNVTSTSRLAFAQVPGNCK---------VVDAVMV-------- 720
             .|.||.|:.  |.||.:|......:..:.|::..|....|         ..|:..|
Human   798 -NLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWST 861

  Fly   721 -CDLN----RGRPLAKGDTDSVTISFDVS--QLSGQSLIIHAEVFSTGYEQN-PTDNRQTNVIGL 777
             |.:|    ||     |...:...:||||  .:.|..|::.|.|.|   |.| |..::.|..:.|
Human   862 SCRINHLIFRG-----GAQITFLATFDVSPKAVLGDRLLLTANVSS---ENNTPRTSKTTFQLEL 918

  Fly   778 -------------KEFTEIDASGGQTNSQIDLEHYSNSAE-----IVNNYEIKSNGPSVIEQLTV 824
                         ::||:             ..::|.|.|     .::.|::.:.|...: .:::
Human   919 PVKYAVYTVVSSHEQFTK-------------YLNFSESEEKESHVAMHRYQVNNLGQRDL-PVSI 969

  Fly   825 SFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLER 889
            :|::|:                 .|..:|.:    :.:::....|..|.....::....|..|
Human   970 NFWVPV-----------------ELNQEAVW----MDVEVSHPQNPSLRCSSEKIAPPASDFL-- 1011

  Fly   890 TVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLS 954
                           .|: |...|||.|:   |...|.|.|:.:.:...|             |.
Human  1012 ---------------AHI-QKNPVLDCSI---AGCLRFRCDVPSFSVQEE-------------LD 1044

  Fly   955 DDFKGKLPVN--RTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEY 1017
            ...||.|...  |.|                              ::..|.:..|..|..|...|
Human  1045 FTLKGNLSFGWVRQI------------------------------LQKKVSVVSVAEITFDTSVY 1079

  Fly  1018 FVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKF 1082
            ..:           |...:|   .|.:...:.:..:...|..:|:.|.|||||||:.|:.:|||.
Human  1080 SQL-----------PGQEAF---MRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVLYKV 1130

  Fly  1083 GFFNRTKKDELDRLVQQNPVEPE 1105
            |||.|..|:.::....|  :.||
Human  1131 GFFKRQYKEMMEEANGQ--IAPE 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	16/52 (31%)
		FG-GAP	350..388	CDD:280083	10/37 (27%)
		Int_alpha	409..459	CDD:214549	20/52 (38%)
		Int_alpha	473..>515	CDD:214549	17/41 (41%)
		Integrin_alpha2	507..829	CDD:285619	78/397 (20%)
ITGAX	NP_001273304.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	23..78		16/49 (33%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	79..138		13/73 (18%)
		vWA_integrins_alpha_subunit	150..325	CDD:238746	7/174 (4%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	340..391		18/63 (29%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	392..443		14/76 (18%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	444..504		15/59 (25%)
		Int_alpha	454..504	CDD:214549	13/49 (27%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	507..565		18/57 (32%)
		Int_alpha	517..>558	CDD:214549	17/40 (43%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	570..630		23/64 (36%)
		Int_alpha	582..628	CDD:214549	17/47 (36%)
		Integrin_alpha2	615..1032	CDD:285619	93/497 (19%)
		Integrin_alpha	1129..1143	CDD:278771	6/13 (46%)
		GFFKR motif	1131..1135		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840