Protein Alignment scb and pat-2

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: NP_498948.1
• Gene: pat-2 / 176240
• WormBaseID: WBGene00003929
• Length: 1226
• Species: Caenorhabditis elegans
• Alignment Length: 1316
• Identity: 311/1316 - (23%)
• Similarity: 498/1316 - (37%)
• Gaps: 326/1316 - (24%)

  Fly     8 FPH---IFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTS-----I 64
            ||.   :.|.||.|::.:..||.         ..|::..|  ....:||||:|......     :
 Worm     6 FPRRIGLLLGLLGLLAGVATFNI---------DTKNVVVH--HMAGNYFGYSLDFYHEQKGMPVL 59

  Fly    65 IVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDS-RGNVDAPYSEYTFDSERKDFQWLG 128
            :||||.|:|...:...|...||:|.||:....|....:|. :||:......:....|.|..|:.|
 Worm    60 VVGAPEAESNNPNLAGIRRPGAVYACSVNRATCREVHVDKMKGNLKKLNGSHLVPIEEKSHQFFG 124

  Fly   129 GSMDGGTKDTDKLLVCAPRFYAPSSRDNHLH--GVCYWVNN------TVASTPQHVTRISPLRLK 185
            .::....|. ||::||||::....|:...:.  |.|::..|      ..:|..|...|....||.
 Worm   125 ATVRSNDKH-DKIVVCAPKYTYFYSKFEVIEPVGTCFYAENGFDNAEEFSSCKQEPARHGRHRLG 188

  Fly   186 SEQVKEEDNGNKASFFYIMGELGLSAHV--ADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTA 248
                              .|:.|.||.|  ..:..:..|||||:..|:|::......:..|.|
 Worm   189 ------------------YGQCGFSAAVPGKKNQNRVFIGAPGVWYWQGAMFSQNIKNQTDRP-- 233

  Fly   249 SRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVA 313
                             :.:|..:.|             :....||:.::|.||......:  ||
 Worm   234 -----------------NTEYGSKEY-------------DHDMMGYSTATGDFDGDGIDDI--VA 266

  Fly   314 TAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQH---- 374
            ..|:.|...|:..::..:.|.:.........|.|:|.|.||...|:|.||:.|:|:..|.:
 Worm   267 GVPRGNDLHGKLVLYTSKLKMMINLTDEVSTQHGQYCGGSVAVADVNKDGRDDIIMGCPFYTDYG 331

  Fly   375 ALEDS--------HDNGAIYVFINKGFFNFERQILRSPVETMARFGTALSRLGDINHDGYNDVAV 431
            :::|:        :|.|.:.|.:......|.:||.....:...|||.|::..||:|.||||||.|
 Worm   332 SVKDAKTQERKPQYDVGKVIVMLQTAPGVFGKQIAVVGDDQWGRFGHAVAAAGDLNLDGYNDVIV 396

  Fly   432 GAPFAG---NGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFA 493
            |||:||   .|.|::..||::|:|:.|:|:::..:.......|  ||..|:...|:||||..|.|
 Worm   397 GAPYAGKNKQGAVYVIHGSKDGVRELPTQKIEGANIGHGNIKS--FGFSLTGNEDVDGNGMPDIA 459

  Fly   494 IGA---PNAEAVYLYRAYPVVKVHATVKSESREIKPEQE------KVKITACYRLST-------- 541
            :||   .|| ||.|.:  |||.|....:.||..|..|.:      |:...||..::|
 Worm   460 VGAWKSGNA-AVLLTK--PVVTVTGQTEPESALISVEDKNCDVDGKLGKQACKHINTCFKYEGKG 521

  Fly   542 -TSTDKLVQEQELAIRIAMDKQL--KRVKFTQTQT-NEISFKVNANFGEQCRD----FETQVRYS 598
             |..|     .|..:|..:|...  .|..|.|... ::.|.||..  |.:.||    .|.:||..
 Worm   522 DTPND-----LEFDLRFNLDDHSPEPRAYFLQKDVKSDRSIKVAQ--GSKTRDHPSSIEQRVRLE 579

  Fly   599 E----------------KDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQN-IIFS 646
            :                ||..:||...::|...:.........:....:|.|.| :|.|| |..:
 Worm   580 KGRQKCFRHRFFASSTMKDKLSPIHWSVNYTYVESKTGKLRGDKLEPAIDTTVP-LSFQNKINIA 643

  Fly   647 TGCA-TDVCTADLQLRSKDVSPTYILGSAD-TLRLNYEITNIGETAY-------LPQ----FNVT 698
            ..|. .|:|..||::.:......::||:.| |:.:|..:.|.||.:|       :||    ..:.
 Worm   644 NNCGKDDLCVPDLKVTAVADREKFLLGTQDNTMLINVTVQNGGEDSYETKLYFDVPQGFEYGGIE 708

  Fly   699 STSRLAFAQVPGNCKVVDA-------VMVCDLNRGRPLAKGDTDS----VTISFDVSQLSGQSLI 752
            |.........|......|.       ...|||  |.||......|    ||.|.|...|:  .:.
 Worm   709 SVGGDGSKSAPACSPTSDEPDSDGKWTFACDL--GNPLPANKVVSSVVRVTASSDKPPLA--PIS 769

  Fly   753 IHAEVFSTGYEQNPT--DNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNS----------AEI 805
            |:|.|.|:..|:..|  ||:.|..|.:....::..:|.....|:|....:.:          ..:
 Worm   770 INAHVNSSNDEEAHTVADNKVTFTIPVDFKNQLSLNGRSNPEQVDFSMTNKTRVDAFDDNEIGPV 834

  Fly   806 VNN-YEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAII---PIINVTSL-KMQASYDSQLLSIDLY 865
            |:: |:|.:.|||.::..|:..:.|......|....|   |::|..:. :.:......:..::|.
 Worm   835 VSHLYQISNRGPSEVDSATLDIFWPSFSTEGGHLLYIITEPVVNPPNKGRCRVKQLQNVNPLNLR 899

  Fly   866 DQNNTMLVVDPV-----------------EVTTTLSGGLERTVITQNRQSYDIHTSGHVH----- 908
            ..|..:....||                 :.|||.|    ::...|:.|....|.||.||
 Worm   900 ITNEHVPTEPPVAKTPNEYSREEDDESYEDETTTQS----QSTRHQSTQHQTHHQSGPVHVYEKD 960

  Fly   909 ----------------------------------QTMEVLDTSMVATASMSRKRRDLKALTAN-- 937
                                              ...|..|......|...|.:|:.......
 Worm   961 EEKIRQNTGNWQYVEDKKKKGDYEYIPDDQEYDGDDFEEEDDEDFDRAGSKRVKRNPTPKKKKKG 1025

  Fly   938 -------REQYARISNVKAHDLLSD------DFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFR 989
                   |...||.|:::....||.      |:||  |::|..|    |.....|...|..::
 Worm  1026 GEHRGEPRSDKARFSDLREAVKLSKEAGGVVDYKG--PLSRASV----DCNSLRCTHIECDIY-- 1082

  Fly   990 PEKSINLNMRYSVDLNEVNAILVDPWE--YFVILTDLKLQKKGD--------PTSTSFSINRR-- 1042
                         ||.|...:||:.:.  |...|.|.| ...||        .|||.:::..:
 Worm  1083 -------------DLKEDEFVLVEIFSRLYTNTLVDEK-NPGGDISSLALARVTSTKYNLPHKPT 1133

  Fly  1043 ------IEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNR----TKKDEL--DR 1095
                  ...|.|:..:...||.|:.:::::.||.:|..:..||::.|||.|    |:..||  ||
 Worm  1134 LITAVSTNMNAIASEEGRDLPWWLYLLAILIGLAILILLILLLWRCGFFKRNRPPTEHAELRADR 1198

  Fly  1096 LVQQNPVEPEAENLNS 1111
                   :|.|:..:|
 Worm  1199 -------QPNAQYADS 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/56 (32%)
		FG-GAP	350..388	CDD:460357	13/49 (27%)
		Int_alpha	409..459	CDD:214549	27/52 (52%)
		Int_alpha	473..>515	CDD:214549	21/44 (48%)
		Integrin_alpha2	509..829	CDD:462478	92/395 (23%)
pat-2	NP_498948.1	Int_alpha	39..98	CDD:214549	18/58 (31%)
		Int_alpha	299..359	CDD:214549	16/59 (27%)
		Int_alpha	372..427	CDD:214549	27/54 (50%)
		Int_alpha	440..>462	CDD:214549	10/21 (48%)
		Integrin_alpha2	474..936	CDD:462478	105/479 (22%)
		Integrin_alpha	1178..1192	CDD:459778	5/13 (38%)