DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itga5

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_034707.5	Gene:	Itga5 / 16402	MGIID:	96604	Length:	1053	Species:	Mus musculus

Alignment Length:	1217	Identity:	301/1217 - (24%)
Similarity:	458/1217 - (37%)	Gaps:	353/1217 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALLALI----SHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQ-----TSIIVGA 68
            |.||.|:    ..:..||.......|::.|.          .|.||:::...:     .|::|||
Mouse    29 LPLLLLLWPPPLQVGGFNLDAEAPAVLSGPP----------GSLFGFSVEFYRPGRDGVSVLVGA 83

  Fly    69 PRAQSTLESQRTINETGAIYRCSL-TNGV-CSPYVLDSRGNVDAPYSEYTFDSER----KDFQWL 127
            |:|.:   ||..:.:.||:|.|.. |:.: |:....||:|:.....|.|:...|.    |..||.
Mouse    84 PKANT---SQPGVLQGGAVYVCPWGTSPIQCTTIQFDSKGSRILESSLYSAKGEEPVEYKSLQWF 145

  Fly   128 GGSMDGGTKDTDKLLVCAPRFYAPSSRD--NHLHGVCYWVNNTVASTPQHVTRI---SPLRLKSE 187
            |.::   ......:|.|||.:...:.:|  |...|.||      .|| ::.|||   :|.|
Mouse   146 GATV---RAHGSSILACAPLYSWRTEKDPQNDPVGTCY------LST-ENFTRILEYAPCR---- 196

  Fly   188 QVKEEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRD 252
                .|.|:.|...|..|  |.||...... :.::|.||...|:|.::           :|::..
Mouse   197 ----SDFGSAAGQGYCQG--GFSAEFTKTG-RVVLGGPGSYFWQGQIL-----------SATQEQ 243

  Fly   253 TSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQ---------EEDSYFGYAVSSGFFDSSNPTK 308
            .|                 |.|.||.....:.||         .:|||.||:|:.|.|...:...
Mouse   244 IS-----------------ESYYPEYLINPVQGQLQTRQASSVYDDSYLGYSVAVGEFSGDDTED 291

  Fly   309 LLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQ 373
              :||..|:.|...|  |:..:.|..||..:...|||...||||:|.|.|.||||..|::|.||.
Mouse   292 --FVAGVPKGNLTYG--YVTVLNGSDIHSLYNVSGEQMASYFGYAVAATDTNGDGLDDLLVGAPL 352

  Fly   374 HALEDSHDN-----GAIYVFINKGFFNFERQILRSPVETM--------ARFGTALSRLGDINHDG 425
             .:|.:.|.     |.:|:::       :|.....|..|:        :|||::|:.|||::.||
Mouse   353 -LMERTADGRPQEVGRVYIYL-------QRPAGIDPTPTLTLTGQDEFSRFGSSLTPLGDLDQDG 409

  Fly   426 YNDVAVGAPFAG---NGTVFIYLGSENGLRDQPSQRLD---APSQQPSKYGSHMFGHGLSRGSDI 484
            |||||:||||.|   .|.|||:.|...||..:|||.|.   |..:.|..:||.:.|     |.|:
Mouse   410 YNDVAIGAPFGGEAQQGVVFIFPGGPGGLSTKPSQVLQPLWAAGRTPDFFGSALRG-----GRDL 469

  Fly   485 DGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEKVKI----TACYRLS--TTS 543
            ||||:.|..:|:...:...:||..|::...|::........||:....:    .:|..||  ..:
Mouse   470 DGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNA 534

  Fly   544 TDKLV--------------QEQELAIRIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRDFETQ 594
            :.|.|              |:|:..:|.|:....|:...|||      ..:.....|.||:.:..
Mouse   535 SGKHVPNSIGFEVELQLDWQKQKGGVRRALFLTSKQATLTQT------LLIQNGAREDCREMKIY 593

  Fly   595 VRYSE--KDIFTPIDLEMHYELTKKVP-DSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VCT 655
            :|...  :|..:||.:.:::.|..|.| ||............:..:...|.::   .|..| :|.
Mouse   594 LRNESEFRDKLSPIHIALNFSLDPKAPMDSHGLRPVLHYQSKSRIEDKAQILL---DCGEDNICV 655

  Fly   656 ADLQLRSKDVSPTYILGSADTLRLNYEITNIGE-TAYLPQFNVTSTSRLAFAQV---PGNCKVVD 716
            .||||..........||..:.|.|.:...|:|| .||..:..||:.....::.:   |||...:.
Mouse   656 PDLQLDVYGEKKHVYLGDKNALNLTFHAQNLGEGGAYEAELRVTAPLEAEYSGLVRHPGNFSSLS 720

  Fly   717 ----AV-----MVCDLNRGRPLAKG---------------DTDSVTISFDVSQLSGQSLIIHAEV 757
                ||     :||||  |.|:..|               ||.. ||.||...||
Mouse   721 CDYFAVNQSRQLVCDL--GNPMKAGTSLWGGLRFTVPHLQDTKK-TIQFDFQILS---------- 772

  Fly   758 FSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIV---------------- 806
                   ...:|.|:||:......|..|       |:.|...|....::
Mouse   773 -------KNLNNSQSNVVSFPLSVEAQA-------QVSLNGVSKPEAVIFPVSDWNPQDQPQKEE 823

  Fly   807 -------NNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDL 864
                   :.||:.:.|||.|.|..:....|.|.:   ...::.:..||.|....|.
Mouse   824 DLGPAVHHVYELINQGPSSISQGVLELSCPQALE---GQQLLYVTKVTGLSNCTSN--------- 876

  Fly   865 YDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRR 929
            |..|:..|.:||                         .||.|..|..|....|..|:.
Mouse   877 YTPNSQGLELDP-------------------------ETSPHHLQKREAPGRSSTASG------- 909

  Fly   930 DLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRP---- 990
                                                |.|..|  ||.. |.|  :|..|.|
Mouse   910 ------------------------------------TQVLKC--PEAK-CFR--LRCEFGPLHRQ 933

  Fly   991 -EKSINLNMR-------------YSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINR 1041
             .:|:.|:.|             :|:....|...|..|  |.::...|..:|....|:..::
Mouse   934 ESRSLQLHFRVWAKTFLQREYQPFSLQCEAVYEALKMP--YQILPRQLPQKKLQVATAVQWT--- 993

  Fly  1042 RIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRT 1088
                   ......|:|:||||::::.|||||..:.|:|||.|||.|:
Mouse   994 -------KAEGSNGVPLWIIILAILFGLLLLGLLIYVLYKLGFFKRS 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	17/58 (29%)
		FG-GAP	350..388	CDD:280083	18/42 (43%)
		Int_alpha	409..459	CDD:214549	29/52 (56%)
		Int_alpha	473..>515	CDD:214549	12/41 (29%)
		Integrin_alpha2	507..829	CDD:285619	84/396 (21%)
Itga5	NP_034707.5	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	46..111		19/77 (25%)
		Int_alpha	59..117	CDD:214549	17/70 (24%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	131..191		19/69 (28%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	196..248		17/90 (19%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	262..314		15/55 (27%)
		Int_alpha	271..>313	CDD:214549	15/45 (33%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	315..380		24/72 (33%)
		Int_alpha	325..382	CDD:214549	21/64 (33%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	381..440		27/58 (47%)
		Int_alpha	392..446	CDD:214549	29/53 (55%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	444..507		19/67 (28%)
		Int_alpha	458..510	CDD:214549	15/56 (27%)
		Integrin_alpha2	493..925	CDD:285619	109/552 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..910		11/98 (11%)
		GFFKR motif	1024..1028		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832080
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740