DRSC/TRiP Functional Genomics Resources

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Protein Alignment scb and Itga5

DIOPT Version :10

Sequence 1:NP_523750.2 Gene:scb / 36692 FlyBaseID:FBgn0286785 Length:1115 Species:Drosophila melanogaster
Sequence 2:NP_034707.5 Gene:Itga5 / 16402 MGIID:96604 Length:1053 Species:Mus musculus


Alignment Length:1217 Identity:301/1217 - (24%)
Similarity:458/1217 - (37%) Gaps:353/1217 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LALLALI----SHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQ-----TSIIVGA 68
            |.||.|:    ..:..||.......|::.|.          .|.||:::...:     .|::|||
Mouse    29 LPLLLLLWPPPLQVGGFNLDAEAPAVLSGPP----------GSLFGFSVEFYRPGRDGVSVLVGA 83

  Fly    69 PRAQSTLESQRTINETGAIYRCSL-TNGV-CSPYVLDSRGNVDAPYSEYTFDSER----KDFQWL 127
            |:|.:   ||..:.:.||:|.|.. |:.: |:....||:|:.....|.|:...|.    |..||.
Mouse    84 PKANT---SQPGVLQGGAVYVCPWGTSPIQCTTIQFDSKGSRILESSLYSAKGEEPVEYKSLQWF 145

  Fly   128 GGSMDGGTKDTDKLLVCAPRFYAPSSRD--NHLHGVCYWVNNTVASTPQHVTRI---SPLRLKSE 187
            |.::   ......:|.|||.:...:.:|  |...|.||      .|| ::.|||   :|.|    
Mouse   146 GATV---RAHGSSILACAPLYSWRTEKDPQNDPVGTCY------LST-ENFTRILEYAPCR---- 196

  Fly   188 QVKEEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRD 252
                .|.|:.|...|..|  |.||...... :.::|.||...|:|.::           :|::..
Mouse   197 ----SDFGSAAGQGYCQG--GFSAEFTKTG-RVVLGGPGSYFWQGQIL-----------SATQEQ 243

  Fly   253 TSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQ---------EEDSYFGYAVSSGFFDSSNPTK 308
            .|                 |.|.||.....:.||         .:|||.||:|:.|.|...:...
Mouse   244 IS-----------------ESYYPEYLINPVQGQLQTRQASSVYDDSYLGYSVAVGEFSGDDTED 291

  Fly   309 LLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQ 373
              :||..|:.|...|  |:..:.|..||..:...|||...||||:|.|.|.||||..|::|.||.
Mouse   292 --FVAGVPKGNLTYG--YVTVLNGSDIHSLYNVSGEQMASYFGYAVAATDTNGDGLDDLLVGAPL 352

  Fly   374 HALEDSHDN-----GAIYVFINKGFFNFERQILRSPVETM--------ARFGTALSRLGDINHDG 425
             .:|.:.|.     |.:|:::       :|.....|..|:        :|||::|:.|||::.||
Mouse   353 -LMERTADGRPQEVGRVYIYL-------QRPAGIDPTPTLTLTGQDEFSRFGSSLTPLGDLDQDG 409

  Fly   426 YNDVAVGAPFAG---NGTVFIYLGSENGLRDQPSQRLD---APSQQPSKYGSHMFGHGLSRGSDI 484
            |||||:||||.|   .|.|||:.|...||..:|||.|.   |..:.|..:||.:.|     |.|:
Mouse   410 YNDVAIGAPFGGEAQQGVVFIFPGGPGGLSTKPSQVLQPLWAAGRTPDFFGSALRG-----GRDL 469

  Fly   485 DGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEKVKI----TACYRLS--TTS 543
            ||||:.|..:|:...:...:||..|::...|::........||:....:    .:|..||  ..:
Mouse   470 DGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNA 534

  Fly   544 TDKLV--------------QEQELAIRIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRDFETQ 594
            :.|.|              |:|:..:|.|:....|:...|||      ..:.....|.||:.:..
Mouse   535 SGKHVPNSIGFEVELQLDWQKQKGGVRRALFLTSKQATLTQT------LLIQNGAREDCREMKIY 593

  Fly   595 VRYSE--KDIFTPIDLEMHYELTKKVP-DSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VCT 655
            :|...  :|..:||.:.:::.|..|.| ||............:..:...|.::   .|..| :|.
Mouse   594 LRNESEFRDKLSPIHIALNFSLDPKAPMDSHGLRPVLHYQSKSRIEDKAQILL---DCGEDNICV 655

  Fly   656 ADLQLRSKDVSPTYILGSADTLRLNYEITNIGE-TAYLPQFNVTSTSRLAFAQV---PGNCKVVD 716
            .||||..........||..:.|.|.:...|:|| .||..:..||:.....::.:   |||...:.
Mouse   656 PDLQLDVYGEKKHVYLGDKNALNLTFHAQNLGEGGAYEAELRVTAPLEAEYSGLVRHPGNFSSLS 720

  Fly   717 ----AV-----MVCDLNRGRPLAKG---------------DTDSVTISFDVSQLSGQSLIIHAEV 757
                ||     :||||  |.|:..|               ||.. ||.||...||          
Mouse   721 CDYFAVNQSRQLVCDL--GNPMKAGTSLWGGLRFTVPHLQDTKK-TIQFDFQILS---------- 772

  Fly   758 FSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIV---------------- 806
                   ...:|.|:||:......|..|       |:.|...|....::                
Mouse   773 -------KNLNNSQSNVVSFPLSVEAQA-------QVSLNGVSKPEAVIFPVSDWNPQDQPQKEE 823

  Fly   807 -------NNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDL 864
                   :.||:.:.|||.|.|..:....|.|.:   ...::.:..||.|....|.         
Mouse   824 DLGPAVHHVYELINQGPSSISQGVLELSCPQALE---GQQLLYVTKVTGLSNCTSN--------- 876

  Fly   865 YDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRR 929
            |..|:..|.:||                         .||.|..|..|....|..|:.       
Mouse   877 YTPNSQGLELDP-------------------------ETSPHHLQKREAPGRSSTASG------- 909

  Fly   930 DLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRP---- 990
                                                |.|..|  ||.. |.|  :|..|.|    
Mouse   910 ------------------------------------TQVLKC--PEAK-CFR--LRCEFGPLHRQ 933

  Fly   991 -EKSINLNMR-------------YSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINR 1041
             .:|:.|:.|             :|:....|...|..|  |.::...|..:|....|:..::   
Mouse   934 ESRSLQLHFRVWAKTFLQREYQPFSLQCEAVYEALKMP--YQILPRQLPQKKLQVATAVQWT--- 993

  Fly  1042 RIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRT 1088
                   ......|:|:||||::::.|||||..:.|:|||.|||.|:
Mouse   994 -------KAEGSNGVPLWIIILAILFGLLLLGLLIYVLYKLGFFKRS 1033

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scbNP_523750.2 Int_alpha 51..103 CDD:214549 17/58 (29%)
FG-GAP 350..388 CDD:460357 18/42 (43%)
Int_alpha 409..459 CDD:214549 29/52 (56%)
Int_alpha 473..>515 CDD:214549 12/41 (29%)
Integrin_alpha2 509..829 CDD:462478 84/394 (21%)
Itga5NP_034707.5 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 46..111 19/77 (25%)
Int_alpha 59..117 CDD:214549 17/70 (24%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 131..191 19/69 (28%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 196..248 17/90 (19%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 262..314 15/55 (27%)
Int_alpha 271..>313 CDD:214549 15/45 (33%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 315..380 24/72 (33%)
Int_alpha 325..382 CDD:214549 21/64 (33%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 381..440 27/58 (47%)
Int_alpha 392..446 CDD:214549 29/53 (55%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 444..507 19/67 (28%)
Int_alpha 458..510 CDD:214549 15/56 (27%)
Integrin_alpha2 493..925 CDD:462478 109/552 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 879..910 11/98 (11%)
GFFKR motif. /evidence=ECO:0000305 1024..1028 3/3 (100%)
Interaction with HPS5. /evidence=ECO:0000250|UniProtKB:P08648 1025..1032 5/6 (83%)

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