DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8079 and Rbm5

DIOPT Version :9

Sequence 1:	NP_611023.1	Gene:	CG8079 / 36689	FlyBaseID:	FBgn0034002	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001346454.1	Gene:	Rbm5 / 83486	MGIID:	1933204	Length:	815	Species:	Mus musculus

Alignment Length:	602	Identity:	119/602 - (19%)
Similarity:	189/602 - (31%)	Gaps:	216/602 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TKLASYKQKLLHYVSR-----EEKVSCDKASQATESELQECQYSMENDEDTN-------KKDQPN 104
            |:...|.|....:..:     |...|....:..|.:.......|.:....|:       ::.||:
Mouse   369 TQYTQYSQDYQQFYQQQAGGLESDTSATSGTTVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPS 433

  Fly   105 DLSATDAFSFVDEMRQAA---------KHA-ENLNNFVYEHTSGMYYDPKTGYYYNAEYGLYYDG 159
            ..::|.|        .||         |:| .:.:.:.|:.:||.||||.||.||:.....||:.
Mouse   434 TSTSTQA--------PAASPTGVVPGTKYAVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNS 490

  Fly   160 NNGCYYSYDHAKDSYEFHSQAQVQANDAAKPESEDEDLEVQFDELGGVITDHETLKKIKAEKQKA 224
            ....|..:|..|::|.  ..|:..:|......|..|..|            .:...|.|..:|.|
Mouse   491 LTQQYLYWDGEKETYV--PAAEASSNQQTGLPSTKEGKE------------KKEKPKSKTAQQIA 541

  Fly   225 KDQAEKSKRKAKKKKSKKHS--------------------------KKRSKKERRHKSKKRHRHS 263
            ||....:|...|:|::.|:|                          ||.:..||:....:..|:.
Mouse   542 KDMERWAKSLNKQKENFKNSFQPVNSLREEERRESAAADAGFALFEKKGALAERQQLLPELVRNG 606

  Fly   264 DDERSNDAEEGELSQSSDSSSDSSNEDSSSNTEDSSVPVFKAAGRFQDIAKKYPPSLRIIVQETN 328
            |:|  |..:.|.::.   .|.||.||                                    |..
Mouse   607 DEE--NPLKRGLVAA---YSGDSDNE------------------------------------EEL 630

  Fly   329 VESLKVGSLHLITYKGGSLGREGAHDVIIPDVNVSKCHLKFKYENKLGIYQCL-DLGSRNGTILN 392
            ||.|:.....|..:|               .:....|..:|...:.|..:|.| ||..:|..|..
Mouse   631 VERLESEEEKLADWK---------------KMACLLCRRQFPNRDALVRHQQLSDLHKQNMDIYR 680

  Fly   393 GSPMSSDAMDLVHGSVITLGQTRLLCHVHEGNSTCGLCEPGLLIENSPPVVAAVASSTASVLSHK 457
            .|.:|...::.:
Mouse   681 RSRLSEQELEAL----------------------------------------------------- 692

  Fly   458 EQLKKLQRKYGLENEKFVDTSGNGQSNYNDRAATRRVQVG-----SSTDKEKTEVACVNTE---- 513
             :|::.:.|                  |.||||.||.:.|     ....|::.:...||.|
Mouse   693 -ELREREMK------------------YRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTK 738

  Fly   514 --IGSSNKGFKMLSKLGWQKGEKLGKTNASAGLLEPINVVANEGTSGLGNSDPVLSSSRTIDKRK 576
              |..||.|.|||..:||::|..||:  ...|:..||........:|||........|.. |..|
Mouse   739 DGIDHSNIGNKMLQAMGWREGSGLGR--KCQGITAPIEAQVRLKGAGLGAKGSAYGLSGA-DSYK 800

  Fly   577 LANLKITQARYQRASDM 593
            .|   :.:|.:.|.::|
Mouse   801 DA---VRKAMFARFTEM 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8079	NP_611023.1	OCRE_VG5Q	124..177	CDD:293883	18/53 (34%)
		OCRE repeat 1	129..136	CDD:293883	1/6 (17%)
		OCRE repeat 2	137..144	CDD:293883	5/6 (83%)
		OCRE repeat 3	145..152	CDD:293883	4/6 (67%)
		OCRE repeat 4	153..159	CDD:293883	2/5 (40%)
		OCRE repeat 5	162..169	CDD:293883	1/6 (17%)
		FHA	346..411	CDD:278899	11/65 (17%)
		G-patch	516..560	CDD:279867	15/43 (35%)
Rbm5	NP_001346454.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93
		RRM1_RBM5	93..179	CDD:241196
		zf-RanBP	183..210	CDD:366216
		RanBP2-type Zn finger	185..204	CDD:275375
		RRM2_RBM5	229..314	CDD:241199
		Required for interaction with U2AF2. /evidence=ECO:0000250	321..809		117/595 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..468		14/90 (16%)
		Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200. /evidence=ECO:0000250	452..535		25/96 (26%)
		OCRE_RBM5	455..510	CDD:293887	18/56 (32%)
		OCRE repeat 1	460..467	CDD:293887	1/6 (17%)
		OCRE repeat 2	468..475	CDD:293887	5/6 (83%)
		OCRE repeat 3	476..483	CDD:293887	4/6 (67%)
		OCRE repeat 4	484..491	CDD:293887	2/6 (33%)
		OCRE repeat 5	493..500	CDD:293887	1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..539		7/42 (17%)
		G-patch	743..785	CDD:366717	15/43 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900