Protein Alignment CG8079 and AGGF1

DIOPT Version :10

• Sequence 1: NP_611023.1
• Gene: CG8079 / 36689
• FlyBaseID: FBgn0034002
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_060516.2
• Gene: AGGF1 / 55109
• HGNCID: 24684
• Length: 714
• Species: Homo sapiens
• Alignment Length: 705
• Identity: 195/705 - (27%)
• Similarity: 315/705 - (44%)
• Gaps: 133/705 - (18%)

  Fly     7 EEDLADTVAKYDSIELKSIQDLETCEQQ-----QLLQYVEKLHGIIRKYDTKLASYKQKLLHYVS 66
            |.:||....|.:.:|    ::|.:|::|     :||.:.|:|:......:.:|.:..::|...:.
Human    19 EPELAQLRRKVEKLE----RELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQ 79

  Fly    67 R---EEKVSCD-----------------------------KASQATESELQECQYSMENDED--- 96
            |   |:....|                             |.::.::.:.|..:.|:.|.:|
Human    80 RGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQ 144

  Fly    97 ------------------------TNKKDQPNDLSATD----AFSFVDEMRQAAKHAENLNNFVY 133
                                    :|.::..:.|:..|    ..|..:.:|.||:.|.:...|.|
Human   145 VENDAYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSY 209

  Fly   134 EHTSGMYYDPKTGYYYNAEYGLYYDGNNGCYYSYDHAKDSYEFHSQAQVQA-NDAAKPESEDEDL 197
            :..:|:|:|..||:||::|..||||.:.|.||..|.....|:|||:..:|. ..::..:|:|:.|
Human   210 DENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKL 274

  Fly   198 EVQFDELGGVITDHETLKKIKAEKQKA-------KDQAEKSKRKAKKKKSKKHSKKRSKK----- 250
            :.:..:.....|:.|  |.:.:|.|||       .::.|......||.|...|.|....|
Human   275 KKKRKDPDSSATNEE--KDLNSEDQKAFSVEHTSCNEEENFANMKKKAKIGIHHKNSPPKVTVPT 337

  Fly   251 ------ERRHKSKKRHRHSDDER----SNDAEEGEL--SQSSDSSSDSSNEDSSSNTEDSSVPVF 303
                  ...|::........||:    .::.||||:  ||:.||..::...:.:...|||
Human   338 SGNTIESPLHENISNSTSFKDEKIMETDSEPEEGEITDSQTEDSYDEAITSEGNVTAEDS----- 397

  Fly   304 KAAGRFQDIAKKYPPSLRIIVQETNVESLKVGSLHLIT-YKGGSLGREG--AHDVIIPDVNVSKC 365
                ..:|..|.:||.:|:||..:.|  |::|||.:|| ....::|||.  .|.:.||:|.|||.
Human   398 ----EDEDEDKIWPPCIRVIVIRSPV--LQIGSLFIITAVNPATIGREKDMEHTLRIPEVGVSKF 456

  Fly   366 HLKFKYENKLGIYQCLDLGSRNGTILNGSPM-----SSDAMDLVHGSVITLGQTRLLCHVHEGNS 425
            |.:..:::.|..|..:|.||:||||:||..:     ..|...|.||..:.:|:|.|..|:|.|:.
Human   457 HAEIYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIGETVLSFHIHPGSD 521

  Fly   426 TCGLCEPG------LLIENSPPVVAAVASSTASVLSHKEQLKKLQRKYGLENEKFVDTSGNGQSN 484
            ||..||||      .|.:.....|....|.....|..:::|||::.||||:|.::.|........
Human   522 TCDGCEPGQVRAHLRLDKKDESFVGPTLSKEEKELERRKELKKIRVKYGLQNTEYEDEKTLKNPK 586

  Fly   485 YNDRAATRRVQVGSSTDKEKTEV-ACVNTEIGSSNKGFKMLSKLGWQKGEKLGKTNASAGLLEPI 548
            |.|||..||.||||....::.:. |.|::||..||||.|||.|:||:|||.|||.  ..|:..||
Human   587 YKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKKGEGLGKD--GGGMKTPI 649

  Fly   549 NVVANEGTSGLGNSDPVLSSSRTIDKRKLANLKITQARYQRASDMF----GQSDD 599
            .:......:|||...|  ||...:...:..|.|......:|.::.|    .|.||
Human   650 QLQLRRTHAGLGTGKP--SSFEDVHLLQNKNKKNWDKARERFTENFPETKPQKDD 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8079	NP_611023.1	OCRE_VG5Q	124..177	CDD:293883	20/52 (38%)
		OCRE repeat 1	129..136	CDD:293883	2/6 (33%)
		OCRE repeat 2	137..144	CDD:293883	3/6 (50%)
		OCRE repeat 3	145..152	CDD:293883	4/6 (67%)
		OCRE repeat 4	153..159	CDD:293883	3/5 (60%)
		OCRE repeat 5	162..169	CDD:293883	3/6 (50%)
		FHA_AGGF1	316..433	CDD:438738	48/124 (39%)
		G-patch	516..560	CDD:396249	20/43 (47%)
AGGF1	NP_060516.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		1/2 (50%)
		DUF745	<29..>79	CDD:398808	10/53 (19%)
		OCRE_VG5Q	200..253	CDD:293883	20/52 (38%)
		OCRE repeat 1	205..212	CDD:293883	2/6 (33%)
		OCRE repeat 2	213..220	CDD:293883	3/6 (50%)
		OCRE repeat 3	221..228	CDD:293883	4/6 (67%)
		OCRE repeat 4	229..235	CDD:293883	3/5 (60%)
		OCRE repeat 5	238..245	CDD:293883	3/6 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..307		11/49 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..384		14/61 (23%)
		FHA_AGGF1	406..529	CDD:438738	48/124 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	586..617		12/30 (40%)
		G-patch	620..661	CDD:396249	20/42 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..714		13/50 (26%)