DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8079 and RBM5

DIOPT Version :10

Sequence 1:NP_611023.1 Gene:CG8079 / 36689 FlyBaseID:FBgn0034002 Length:601 Species:Drosophila melanogaster
Sequence 2:NP_005769.1 Gene:RBM5 / 10181 HGNCID:9902 Length:815 Species:Homo sapiens


Alignment Length:691 Identity:136/691 - (19%)
Similarity:214/691 - (30%) Gaps:272/691 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 IELKSIQDLETCEQQQLLQYVEKLHGIIRKYDTK-----LASYKQKLLHYVSREEKVSC-DKASQ 78
            ::|.|..|     ..||||.::.||..: |.|.|     .|...:|.| .:|...:||. ..||.
Human   279 VQLSSAMD-----ASQLLQILQSLHPPL-KIDGKTIGVDFAKSARKDL-VLSDGNRVSAFSVAST 336

  Fly    79 A--------TESE-------------------LQECQYS-------------MENDEDT------ 97
            |        |:|:                   .|..|||             :|:|..:      
Human   337 AIAAAQWSSTQSQSGEGGSVDYSYLQPGQDGYAQYAQYSQDYQQFYQQQAGGLESDASSASGTAV 401

  Fly    98 ---------------NKKDQPNDLSATDAFSFVDEMRQA-----------AKHA-ENLNNFVYEH 135
                           |:...|......:|........||           .|:| .:.:.:.|:.
Human   402 TTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVPGTKYAVPDTSTYQYDE 466

  Fly   136 TSGMYYDPKTGYYYNAEYGLYYDGNNGCYYSYDHAKDSYEFHSQAQVQANDAAKPESEDEDLEVQ 200
            :||.||||.||.||:.....||:.....|..:|..|::|...:::.........|..|.::.:.:
Human   467 SSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAESSSHQQSGLPPAKEGKEKKEK 531

  Fly   201 FDELGGVITDHETLKKIKAEKQKAKDQAEKSKRKAKKKKSKKHS--------------------- 244
                          .|.|..:|.|||....:|...|:|::.|:|                     
Human   532 --------------PKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPVNSLREEERRESAAADAG 582

  Fly   245 -----KKRSKKERRHKSKKRHRHSDDERSNDAEEGELSQSSDSSSDSSNEDSSSNTEDSSVPVFK 304
                 ||.:..||:....:..|:.|:|  |..:.|.::.   .|.||.||               
Human   583 FALFEKKGALAERQQLIPELVRNGDEE--NPLKRGLVAA---YSGDSDNE--------------- 627

  Fly   305 AAGRFQDIAKKYPPSLRIIVQETNVESLKVGSLHLITYKGGSLGREGAHDVIIPDVNVSKCHLKF 369
                                 |..||.|:.....|..:|               .:....|..:|
Human   628 ---------------------EELVERLESEEEKLADWK---------------KMACLLCRRQF 656

  Fly   370 KYENKLGIYQCL-DLGSRNGTILNGSPMSSDAMDLVHGSVITLGQTRLLCHVHEGNSTCGLCEPG 433
            ..::.|..:|.| ||..:|..|...|.:|...::.:                             
Human   657 PNKDALVRHQQLSDLHKQNMDIYRRSRLSEQELEAL----------------------------- 692

  Fly   434 LLIENSPPVVAAVASSTASVLSHKEQLKKLQRKYGLENEKFVDTSGNGQSNYNDRAATRRVQVG- 497
                                     :|::.:.|                  |.||||.||.:.| 
Human   693 -------------------------ELREREMK------------------YRDRAAERREKYGI 714

  Fly   498 ----SSTDKEKTEVACVNTE------IGSSNKGFKMLSKLGWQKGEKLGKTNASAGLLEPINVVA 552
                ....|::.:...||.|      |..||.|.|||..:||::|..||:  ...|:..||....
Human   715 PEPPEPKRKKQFDAGTVNYEQPTKDGIDHSNIGNKMLQAMGWREGSGLGR--KCQGITAPIEAQV 777

  Fly   553 NEGTSGLGNSDPVLSSSRTIDKRKLANLKITQARYQRASDM 593
            ....:|||........|.. |..|.|   :.:|.:.|.::|
Human   778 RLKGAGLGAKGSAYGLSGA-DSYKDA---VRKAMFARFTEM 814

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8079NP_611023.1 OCRE_VG5Q 124..177 CDD:293883 18/53 (34%)
OCRE repeat 1 129..136 CDD:293883 1/6 (17%)
OCRE repeat 2 137..144 CDD:293883 5/6 (83%)
OCRE repeat 3 145..152 CDD:293883 4/6 (67%)
OCRE repeat 4 153..159 CDD:293883 2/5 (40%)
OCRE repeat 5 162..169 CDD:293883 1/6 (17%)
FHA_AGGF1 316..433 CDD:438738 17/117 (15%)
G-patch 516..560 CDD:396249 15/43 (35%)
RBM5NP_005769.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..93
RRM1_RBM5 93..179 CDD:410146
zf-RanBP 181..210 CDD:395516
RanBP2-type Zn finger 185..204 CDD:275375
RRM2_RBM5 229..314 CDD:410149 12/40 (30%)
Required for interaction with U2AF2. /evidence=ECO:0000269|PubMed:18851835 321..809 119/635 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 411..468 8/56 (14%)
Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200. /evidence=ECO:0000269|PubMed:18851835 452..535 22/96 (23%)
OCRE_RBM5 455..510 CDD:293887 18/54 (33%)
OCRE repeat 1 460..467 CDD:293887 1/6 (17%)
OCRE repeat 2 468..475 CDD:293887 5/6 (83%)
OCRE repeat 3 476..483 CDD:293887 4/6 (67%)
OCRE repeat 4 484..491 CDD:293887 2/6 (33%)
OCRE repeat 5 493..500 CDD:293887 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..540 4/46 (9%)
G-patch 743..787 CDD:396249 17/45 (38%)
Blue background indicates that the domain is not in the aligned region.

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