DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GPHR and Gpr89

DIOPT Version :9

Sequence 1:	NP_611016.2	Gene:	GPHR / 36682	FlyBaseID:	FBgn0033995	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_080505.1	Gene:	Gpr89 / 67549	MGIID:	1914799	Length:	455	Species:	Mus musculus

Alignment Length:	449	Identity:	256/449 - (57%)
Similarity:	334/449 - (74%)	Gaps:	7/449 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFLGDCVIVFVSQMIFFAGGWLFFNKELFKHYEIRHISVQLIFSSTFALSITMFELIIFEIIDV 65
            |:||.|..|:..||::||..|||||.::|||.||:|...||:|||.|||.|.||||||||||:.|
Mouse     1 MSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEVRQYVVQVIFSVTFAFSCTMFELIIFEILGV 65

  Fly    66 LESSSRYFHWRLGLTLLLFMTTAVIPIYICYSVIHSISFFSDKWVRIL-TTFCWFIFIYGLWRIG 129
            |.||||||||:|.|.::|.:...::|.||.|.::.:|.....:  |:| :...|..|:|..|::|
Mouse    66 LNSSSRYFHWKLNLCVILLILVFMVPFYIGYFIVSNIQLLHKQ--RLLFSCLLWLTFMYFFWKLG 128

  Fly   130 DPFPLLSASHGIFTIEQGVSRISVIGVTVMAILSGFGAVNYPYTSMSYFIKPVSRNDIICFERRL 194
            ||||:||..|||.:|||.:||:.|||||:||:||||||||.|||.||||::.|:..||:..||||
Mouse   129 DPFPILSPKHGILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRL 193

  Fly   195 ALTVEMLSAKKRKIAMA---IYNHNKLNPSKPRIWDMLASAVQRNTNSGEDINQLKQEVYGLEEL 256
            ..|::|:.:||:::|:|   ::....:......:|.||.| |..:....|::..::|||..||||
Mouse   194 LQTMDMIISKKKRMAVARRTMFQRGDVQNKPSGLWGMLKS-VTASAPGSENLTLIQQEVDALEEL 257

  Fly   257 LRSVFLELSSLKNMEERQRWSQTLKGKYFNVLGHFFSVYCVYKIFMCCINIIFDRVGRKDPVTRG 321
            .|.:|||.:.|...:||..:|:|.||||||.||:|||:|||:||||..|||:.||||:.||||||
Mouse   258 SRQLFLETADLYATKERIEYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVLDRVGKTDPVTRG 322

  Fly   322 LEIAIHWCGFNIDFAFWNQHISFLLVGCIVITSIRGLLLTLTKFFYRISSSKSSNIIVLILGQIM 386
            :||.:::.|...|..||:|||||:|||.|::|||||||:|||||||.||||||||:|||:|.|||
Mouse   323 IEITVNYLGIQFDVKFWSQHISFILVGIIIVTSIRGLLITLTKFFYAISSSKSSNVIVLLLAQIM 387

  Fly   387 GMYFCSSVLLMRMNMPAEYRVIITEVLGNLHFNFYHRWFDVIFLVSALTTIIVLYLSRK 445
            ||||.|||||:||:||.|||.|||||||.|.|||||||||||||||||::|:.|||:.|
Mouse   388 GMYFVSSVLLIRMSMPPEYRTIITEVLGELQFNFYHRWFDVIFLVSALSSILFLYLAHK 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPHR	NP_611016.2	GPHR_N	141..208	CDD:289314	39/66 (59%)
GPHR	NP_611016.2	ABA_GPCR	277..443	CDD:289215	121/165 (73%)
Gpr89	NP_080505.1	GPHR_N	140..207	CDD:372172	39/66 (59%)
Gpr89	NP_080505.1	ABA_GPCR	276..446	CDD:372104	122/169 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849158
Domainoid	1	1.000	260	1.000	Domainoid score	I1971
eggNOG	1	0.900	-	-		E1_KOG2417
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9475
Inparanoid	1	1.050	513	1.000	Inparanoid score	I1293
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55010
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003368
OrthoInspector	1	1.000	-	-		oto92014
orthoMCL	1	0.900	-	-		OOG6_103122
Panther	1	1.100	-	-	LDO	PTHR15948
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4359
SonicParanoid	1	1.000	-	-		X2255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790