Protein Alignment Cyp317a1 and cyp3a4.2

DIOPT Version :10

• Sequence 1: NP_611004.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_001015786.1
• Gene: cyp3a4.2 / 548503
• XenbaseID: XB-GENE-971750
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 774
• Identity: 140/774 - (18%)
• Similarity: 224/774 - (28%)
• Gaps: 277/774 - (35%)

  Fly    89 FETVNKCNDILKNKDDSPSYLPTRLAAICVV-----GCM--------YEKLGRMM--GRSYEETV 138
            |..|:....::|...:..|:.|...:...:.     |||        |.|..|::  |..::||
 Frog   147 FSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQET- 210

  Fly   139 QILLKSLKNAESQSRIEIMMTLEKVCAGMGSAIANVHKDIYKAVRYCLTDRVMAVRVAASNCLLE 203
                  |..|||.|.:          |..||.|||..:.......||..|....|.:....|
 Frog   211 ------LSGAESTSLV----------AARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMC--- 256

  Fly   204 MTGHAPFLYTTELESLASLCFRAFDGCNYEVRCAVARLLGTLIACTQNGSLRNFSSMTASASSTK 268
            ..|.......|......|..|:|..|......|.:                   :|.|.|..:|.
 Frog   257 KAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPI-------------------NSRTTSEGATN 302

  Fly   269 SLRPVSLDEALGVLMAGFLRGGVSFLKGTGEIIKGS-----SGVNREVRVGVTHAYVVFVQTMGG 328
            .           |...|:.|..:..|......|..:     |.||..                 .
 Frog   303 C-----------VCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNET-----------------S 339

  Fly   329 LWLERNLQPFLVHVLDLVANPKAASSHVDAVYSRKCINFILRSVIGKMLGE-KAQSSACKELIHL 392
            |.||             ...|:.:....|.||          ::|.|..|. :...:.|.:.:..
 Frog   340 LMLE-------------WTPPRDSGGREDLVY----------NIICKSCGSGRGACTRCGDNVQY 381

  Fly   393 IAKQMNSIDFNPENAKDSNQETLFSQHLLVCALQELGSLVLLLGTTAQNLLADQSLNFIDAICAV 457
            ..:|:.                |....:.:..|  |..........|.|.:.||| .|.....:|
 Frog   382 APRQLG----------------LTEPRIYISDL--LAHTQYTFEIQAVNGVTDQS-PFSPQFASV 427

  Fly   458 LIHPCMAARLAAAWCLRCVCVAVPGQITPLIDRFIDAIEKMRTSPDAISGY-------------- 508
            .|....||..|         |::..|::    |.:|:|....:.||..:|.
 Frog   428 NITTNQAAPSA---------VSIMHQVS----RTVDSITLSWSQPDQPNGVILDYELQYYEKELS 479

  Fly   509 --------------------SGAL-------AAVLGGVRYSPLGIPHTRGKIIFNTAEELLRTAS 546
                                :||:       ..|.|..|||        ||:.|.|..|.....|
 Frog   480 EYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYS--------GKMYFQTMTEAEYQTS 536

  Fly   547 QNSRLSL--NRTQAGWLLIGAIMTLGVPVVKGLLPRMLLLWRNAFPRSTKELESE---------- 599
            ...:|.|  ..:.||.:.:.|::.:.:...:          |..|.|:..|...:
 Frog   537 IQEKLPLIIGSSAAGLVFLIAVVVIAIVCNR----------RRGFERADSEYTDKLQHYTSGHMT 591

  Fly   600 ---KARGDAFTWQVTLEGRAGALSVMHSFLLHCPELVTDDITRRLLTPIESALAMLINITSVL-- 659
               |...|.||::                       ..::..|.....|:.:   .:.|..|:
 Frog   592 PGMKIYIDPFTYE-----------------------DPNEAVREFAKEIDIS---CVKIEQVIGA 630

  Fly   660 KNYGQ----HLKAPTAMVRLRLYETLSLLPANALESSYTHLLRM-LVSEFTLTENPANTTTSFLR 719
            ..:|:    |||.|.   :..::..:     ..|:|.||...|. .:||           .|.:.
 Frog   631 GEFGEVCSGHLKLPG---KREIFVAI-----KTLKSGYTEKQRRDFLSE-----------ASIMG 676

  Fly   720 QMCHGDDSIILGTWLQDTDHRTIEDQLQPNSAAGSGALEHDA-------CCLYRGIAAG 771
            |..|.:...:.|...:.|....|.:.:: |.:..|...::|.       ..:.||||||
 Frog   677 QFDHPNVIHLEGVVTKSTPVMIITEFME-NGSLDSFLRQNDGQFTVIQLVGMLRGIAAG 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_611004.1	CYP6-like	74..509	CDD:410679	83/474 (18%)
cyp3a4.2	NP_001015786.1	CYP3A	67..495	CDD:410743	83/469 (18%)