Protein Alignment Cyp317a1 and Cyp3a41a

DIOPT Version :10

• Sequence 1: NP_611004.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_059092.2
• Gene: Cyp3a41a / 53973
• MGIID: 1858451
• Length: 504
• Species: Mus musculus
• Alignment Length: 552
• Identity: 140/552 - (25%)
• Similarity: 254/552 - (46%)
• Gaps: 101/552 - (18%)

  Fly     2 WIIFLIIGLLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYS 66
            |::..||       ||||..........::...||..:|   .|.:..::           .:|.
Mouse    12 WVLLAII-------LVLLYRYGTRTHGLFKKQGIPGPKP---LPFLGTVL-----------NYYK 55

  Fly    67 AIYK----KFKGSGPFCGFYALLQPRALILDRELIRQIMIKD----FWN---FNDRGLYCNQKSD 120
            .::|    .::..|...|.:....|..:|.|.|:|:.:::|:    |.|   |...|:.  .|:.
Mouse    56 GLWKFDMECYEKYGKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVGIM--SKAI 118

  Fly   121 PLSGDLYALRGESWKEMRQKLDPSLEGDRM-----------SLLYDCLYEEAEQLLLTVNSTLMS 174
            .:|.|      |.||..|..|.|:....::           .:|...|.:|||:          .
Mouse   119 SISKD------EEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEK----------G 167

  Fly   175 QPHSTVHIQKIMRRYVLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFP 239
            :|   |.::.::..|.:..:....||:|.:.... |.:.|.:..:..|.......|: ..::.||
Mouse   168 KP---VTMKDVLGAYSIDVITSTSFGVNVDSLNN-PEDPFVEKAKGILRVDFFDPLV-FSVVLFP 227

  Fly   240 NFC---RMLRMRRTPKQAEEYFIKLLTSIVEQR-ETSGKPQKDYLQLLIDVKALEFITHQYEADK 300
            ...   .||.:...||.:.|:|.|.:..:.|.| ::..|.:.|:|||:::       .|....||
Mouse   228 FLTPVYEMLNICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMN-------AHNNSKDK 285

  Fly   301 ELGAHLQN-ELAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHE 364
            :....|.: |:.|.::||:.||||.|::|||:.||.||.||::|.:::||:.:.:. :....|::
Mouse   286 DSHKALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLP-NKAPPTYD 349

  Fly   365 GIKSLSFMGQVINETLRMHPITPYILR-----RTLNDYAVPDHPKYILVKELFLIIPTHAIHHDP 424
            .:..:.::..|:|||||::||...:.|     ..||...:|        |...::||::|:||||
Mouse   350 TVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIP--------KGSTVMIPSYALHHDP 406

  Fly   425 DIYPDPEEFKPDRWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFS---- 485
            ..:|:||||:|:|:|.......:...:..||:|.|:|||::||.:.::|||..::..:.|.
Mouse   407 QHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQE 471

  Fly   486 -----LNTRKPLINLEDGIALTLMPLGVIEPG 512
                 ..:|:.|:..|..|.|.::|..|:..|
Mouse   472 TQIPLKLSRQGLLQPEKPIVLKVVPRDVVITG 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_611004.1	CYP6-like	74..509	CDD:410679	125/471 (27%)
Cyp3a41a	NP_059092.2	CYP3A	67..493	CDD:410743	123/464 (27%)