Protein Alignment Cyp317a1 and Cyp3a59

DIOPT Version :10

• Sequence 1: NP_611004.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_001098630.1
• Gene: Cyp3a59 / 100041449
• MGIID: 3769707
• Length: 503
• Species: Mus musculus
• Alignment Length: 525
• Identity: 125/525 - (23%)
• Similarity: 252/525 - (48%)
• Gaps: 73/525 - (13%)

  Fly    10 LLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYSAIYK---- 70
            :|::..||...|...|....::.|.||..:|..|:..|              ..::..::|
Mouse    13 VLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGTI--------------FNYFDGMWKFDED 63

  Fly    71 KFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWN-FNDR------GLYCNQKSDPLSGDLYA 128
            .:|..|...|||...:|...|:|.|:|:.:::|:.:: |.:|      |..  :||..:|.|
Mouse    64 CYKKYGKIWGFYVGPKPILAIMDPEIIKIVLVKECYSVFTNRPTLGPVGFL--KKSITISED--- 123

  Fly   129 LRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKIMRRYVLSS 193
               |.||.:|..|.|:....::..::..:.:..:  :|..|.....:....::::.|...|.:..
Mouse   124 ---EEWKRLRTLLSPTFTSGKLKEMFPIMRQYGD--ILVRNLRREEEKGEPINMKDIFGAYSMDV 183

  Fly   194 LAKCVFGLNAEQRKTYPLEDFEQMTELALNSHKHG-YLMNLMMIRF--PNFCRMLRMRRTPKQAE 255
            :....||:|.:.... |...|.|.|:..|...... :|::.::..|  |.: .||.:...|:.:.
Mouse   184 ITGTSFGVNIDSLNN-PQNPFVQKTKKILKFKIFDPFLLSTILFPFLTPIY-EMLNLSIFPRDSM 246

  Fly   256 EYFIKLLTSIVEQRETS-GKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVFLK 319
            .:|.|.:..:.::|..| .|.:.|:|||:::.:.    :...|:.|.|.   ..|:||.||:|:.
Mouse   247 NFFKKFVKRMKKERLASKQKNRVDFLQLMMNTQN----SKGQESQKALS---DLEMAAQAVIFIF 304

  Fly   320 AGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHP 384
            .||:.|:.::|.::||||.||::|.::::|:.:.:. :...:|::.:..:.::..|:||:||::|
Mouse   305 GGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLP-NKAPVTYDALMDMEYLDMVVNESLRLYP 368

  Fly   385 ITPYILRRT------LNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRD 443
             |...|.|.      :|...:|        |...::||.:.:|.:|:.:|:|:||.|.|:|...:
Mouse   369 -TAIRLERVSKKDVEINGVFIP--------KGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENE 424

  Fly   444 SLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLL--------SEYEFSLN-TRKPLINLEDGI 499
            ...:...:..||.|.|:|:.::||.:.::||:..:|        .|.:..|. :|:|:...|..|
Mouse   425 GNIDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKISREPVFQPEKPI 489

  Fly   500 ALTLM 504
            .|.::
Mouse   490 ILKVV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_611004.1	CYP6-like	74..509	CDD:410679	112/457 (25%)
Cyp3a59	NP_001098630.1	CYP3A	67..492	CDD:410743	111/453 (25%)