DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	514	Identity:	154/514 - (29%)
Similarity:	261/514 - (50%)	Gaps:	56/514 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNK 65
            :::|:.|..:.:.||.|...:.|   .:||:.|||...|....|.  .|..:|.|.....:...|
Zfish     7 LSVTWTLVVLVITLLLIYGVWPH---GFFKKLGIPGPRPLPFVGT--ALSYSKGICNFDIECSKK 66

  Fly    66 FRESKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNKGIFYNEKDDPISAHLFNLDGAQW 129
            :    ....|.:..:.|...|.|||:.|.||:|| :|.|:|:.....:...|.:..:..:...:|
Zfish    67 Y----GKVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRRNMNPDLVGPFADGITLVKDERW 127

  Fly   130 RLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFGI 194
            |.:|:.||..||||::|.::|..::.|:.|:..|.:|.| |..|:|:|:||.:::||:.:.:|.:
Zfish   128 RRIRSSLSPYFTSGRLKEIFPIAMTHADRFIKNMEKKDP-NLPLKIKDVVAPYSLDVVASSSFSV 191

  Fly   195 QCNSLRDEKAEFL-----YFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRIV 254
            ..:|:.:....|:     :|....|...   .||..|..|...|..|:|:...:....:||.:.:
Zfish   192 DFDSINNPDDPFVTSIKSFFNINPLSPL---FLLLAFCPSAANLLAKMGISVFSRSTTDFYYKAL 253

  Fly   255 TETVAVREKEHIKRN---DFMDMLIELKNQ------KEMTLENGDVVRGLTMEEVLAQAFVFFIA 310
            .:.    :.||.:.|   ||:.::|:  ||      |:...|  ..|:|||..|:|:|:|:|.:.
Zfish   254 RKI----KDEHNESNGRVDFLKLMIQ--NQIPDDQVKDTASE--QPVKGLTDHEILSQSFIFILG 310

  Fly   311 GFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNF------TYECTKDLKYLNQVLDET 369
            |:||:|:|:.:.||.||.|||.       :|:::|:.|:||      ||:....:.||...:.|:
Zfish   311 GYETTSTTLSYLLYNLATNPDC-------LEKLVEEIDKNFPLDIPITYDALMRMDYLEMAIHES 368

  Fly   370 LRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESA 434
            :|::...|.|:|:..|...:.|   ..|.....|.||...:..||.::..|.||:|||||||...
Zfish   369 MRVFPAGPRLERVCKKTVEING---ITIPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPESKT 430

  Fly   435 GRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPL----VYDPK 489
            .....|::|||.|||||||:||..|..::.:..|::.:...||.:|..|:    .:.||
Zfish   431 EINQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQIPVQLNFFFQPK 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	143/476 (30%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	144/480 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.720