DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a19 and CYP721A1

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_177649.1	Gene:	CYP721A1 / 843850	AraportID:	AT1G75130	Length:	505	Species:	Arabidopsis thaliana

Alignment Length:	574	Identity:	137/574 - (23%)
Similarity:	236/574 - (41%)	Gaps:	145/574 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAILLGLVVGVLTLV-------AW--WVLQNYTYWKRRGIPHDPPNIPLGNTGELWR------TM 50
            ||:...||:....||       .|  |.:|  :::|::.:......|..||:||:.|      :.
plant     1 MAVFFILVLVFFFLVFRFIYSNIWVPWRIQ--SHFKKQSVTGPSYRIFSGNSGEVSRLTAEAKSK 63

  Fly    51 PL--------------------AGILKRTYLKFRKQTDGPFAGFYLYAMKYIVIT-DVDFVKTVL 94
            |:                    :.:..:|:|             |.:..|.:|.| |...::..|
plant    64 PIPSGRNPHEFVHRVAPHYHEWSRVYGKTFL-------------YWFGSKPVVATSDPRLIREAL 115

  Fly    95 IR--DFDKFHDRGVYHNEKDDPLT-----NNLATIEGQKWKNLRQKLTHTFTSAKMK-----SMF 147
            ..  .||:     :.||    ||:     ..|..:.|.:|...|:.....||..|:|     .:.
plant   116 TTGGSFDR-----IGHN----PLSKLLYAQGLPGLRGDQWAFHRRIAKQAFTMEKLKRWVPQMVT 171

  Fly   148 STVL---------NVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVIGICAFGLKCNSLRDPKA 203
            ||::         |.|:|:             .|||...:...:::::...|||   ||:.:.|
plant   172 STMMLMEKWEDMRNGGEEI-------------ELEVHKEMHNLSAEMLSRTAFG---NSVEEGK- 219

  Fly   204 EFVQMGYSALRERRHGWLVDLLIFGMPKLAVKL-GFQFLLPS------------VQKFYMKIVQD 255
                 |...|:||.      :.:|.:.:.:|.: ||:| .||            ::...:|::::
plant   220 -----GIFELQERM------MRLFYLVRWSVYIPGFRF-FPSKTNREIWRIEKQIRVSILKLIEN 272

  Fly   256 TIDYRMKRKVTRNDFMDTLID--MKQQYDKGDKENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTL 318
            .     |..|.::   .||:.  |....::..:|..|...||..:...|:.|..|..:..|.|.|
plant   273 N-----KTAVEKS---GTLLQAFMSPYTNQNGQEEKLGIEEVTDECKTFYFAAKETTANLMTFVL 329

  Fly   319 YELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINESLRKHPVVAHLARIATKPYQ 383
            ..||.||:.|:..|.|:..||.: .|....|.:|||..:..:|||:||.:|....|.|...|..:
plant   330 VLLAMNQEWQNIAREEVICVLGQ-TGLPTLDILQDLKTLSMIINETLRLYPPAMTLNRDTLKRAK 393

  Fly   384 HSNPKYFIEAGTGVLVSTLGIHHDPEFY-PEPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIG 447
            ..:  ..|.|||.:.:|.:.:|||.|.: .:.|:|.|.||::   .|:.:...:|||.|||.|:|
plant   394 LGD--LDIPAGTQLYLSVVAMHHDKETWGDDAEEFNPRRFED---PKKQSALLVPFGLGPRTCVG 453

  Fly   448 LRFGRMQVIIGLALLIHNFRFELHPK-TPVPMKYTINNLLLGSEGGIHLNITKV 500
            ......:....||.::..:.|.|.|. ...|:.:    :.|..:.|.||..|::
plant   454 QNLAVNEAKTVLATILKYYSFRLSPSYAHAPVLF----VTLQPQNGAHLLFTRI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	124/527 (24%)
CYP721A1	NP_177649.1	p450	26..495	CDD:386267	126/539 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900