Protein Alignment Ciao1 and Ciao1

DIOPT Version :10

• Sequence 1: NP_610996.1
• Gene: Ciao1 / 36655
• FlyBaseID: FBgn0033972
• Length: 335
• Species: Drosophila melanogaster
• Sequence 2: NP_079572.2
• Gene: Ciao1 / 26371
• MGIID: 1346998
• Length: 339
• Species: Mus musculus
• Alignment Length: 330
• Identity: 194/330 - (58%)
• Similarity: 242/330 - (73%)
• Gaps: 3/330 - (0%)

  Fly     4 LILEHTLQGH-KGRIWGVAWHPKGNVFASCGEDKAIRIWSLTGNTWSTKTILSDGHKRTIREIRW 67
            |:|:..:..| ..|.|.:||:|.|.:.||||.|:.||||...|::|..|::||:||:||:|::.|
Mouse     5 LVLQSRVPAHPDSRCWFLAWNPSGTLLASCGGDRKIRIWGTEGDSWICKSVLSEGHQRTVRKVAW 69

  Fly    68 SPCGQYLASASFDATTAIWSKSSGEFECNATLEGHENEVKSVSWSRSGGLLATCSRDKSVWIWEV 132
            ||||.|||||||||||.||.|:..:|||..||||||||||||:|:.||.||||||||||||:|||
Mouse    70 SPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEV 134

  Fly   133 AGDDEFECAAVLNPHTQDVKRVVWHPTKDILASASYDNTIKMFAEEPIDNDWDCTATLTSHTSTV 197
            ..:||:||.:||:.||||||.|||||::::|||||||:|:|::.||  .:||.|.|||..|.|||
Mouse   135 DEEDEYECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKLYQEE--GDDWVCCATLEGHESTV 197

  Fly   198 WGIDFDADGERLVSCSDDTTIKIWRAYHPGNTAGVATPDQQTVWKCVCTVSGQHSRAIYDVSWCK 262
            |.|.||..|:||.|||||.|::|||.|.|||..|||.......|||:||:||.|:|.||||:||:
Mouse   198 WSIAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHTRTIYDVAWCQ 262

  Fly   263 LTGLIATACGDDGIRIFKESSDSKPDEPTFEQITAEEGAHDQDVNSVQWNPVVAGQLISCSDDGT 327
            |||.:|||||||.||:|:|...|.|.:|||........||.||||.|.|||...|.|.||||||.
Mouse   263 LTGALATACGDDAIRVFEEDPGSDPQQPTFSLTAHLRQAHSQDVNCVAWNPKEPGLLASCSDDGE 327

  Fly   328 IKIWK 332
            :..|:
Mouse   328 VAFWE 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ciao1	NP_610996.1	WD40	6..332	CDD:238121	192/326 (59%)
		WD40 repeat	17..57	CDD:293791	19/39 (49%)
		WD40 repeat	63..101	CDD:293791	25/37 (68%)
		WD40 repeat	106..145	CDD:293791	27/38 (71%)
		WD40 repeat	152..191	CDD:293791	22/38 (58%)
		WD40 repeat	197..248	CDD:293791	29/50 (58%)
		WD40 repeat	255..299	CDD:293791	25/43 (58%)
		WD40 repeat	306..331	CDD:293791	14/24 (58%)
Ciao1	NP_079572.2	WD 1	14..53		18/39 (46%)
		WD40	17..332	CDD:238121	190/314 (61%)
		WD40 repeat	19..58	CDD:293791	19/38 (50%)
		WD 2	59..98		26/38 (68%)
		WD40 repeat	65..103	CDD:293791	25/37 (68%)
		WD 3	103..142		29/38 (76%)
		WD40 repeat	108..147	CDD:293791	27/38 (71%)
		WD 4	148..187		24/38 (63%)
		WD40 repeat	154..191	CDD:293791	20/36 (56%)
		LYR motif, required for interaction with HSC20. /evidence=ECO:0000250|UniProtKB:O76071	176..178		0/1 (0%)
		WD 5	192..231		24/38 (63%)
		WD40 repeat	197..248	CDD:293791	29/50 (58%)
		WD 6	250..289		24/38 (63%)
		WD40 repeat	255..295	CDD:293791	25/39 (64%)
		WD 7	301..339		19/33 (58%)
		WD40 repeat	306..331	CDD:293791	15/24 (63%)