Protein Alignment SMC2 and SMC3

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_012461.1
• Gene: SMC3 / 853371
• SGDID: S000003610
• Length: 1230
• Species: Saccharomyces cerevisiae
• Alignment Length: 1329
• Identity: 307/1329 - (23%)
• Similarity: 583/1329 - (43%)
• Gaps: 270/1329 - (20%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            ||:|::::.|||:|...|.|:.|.|....|.|.|||||||...:|.|||. .:..|::....|.|
Yeast     1 MYIKRVIIKGFKTYRNETIIDNFSPHQNVIIGSNGSGKSNFFAAIRFVLS-DDYSNLKREERQGL 64

  Fly    66 VYKNGQAGITKATVTIVF-DNTNPAQCPQGYEKCREISVTRQVVVG-GKNKFLINGKLVQNKKVQ 128
            :::.....:..|:|.||| |..:....|.|.....:..||.:..|| .|:.:.:|.:.|....:.
Yeast    65 IHQGSGGSVMSASVEIVFHDPDHSMILPSGVLSRGDDEVTIRRTVGLKKDDYQLNDRNVTKGDIV 129

  Fly   129 DFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDAT-KTLIEKKETKV 192
            ....:...::|||..::.||||..:.|.|.||.|.::|:..|...::.|..|: |.:.|.::.|:
Yeast   130 RMLETAGFSMNNPYNIVPQGKIVALTNAKDKERLQLLEDVVGAKSFEVKLKASLKKMEETEQKKI 194

  Fly   193 RETKVLLDEEVLPKLVKLRQERSAYQEYQKICR------------------------DIDFLIRI 233
            :..|.:  .|:..||.::.|||...::|.::.|                        |.|:...:
Yeast   195 QINKEM--GELNSKLSEMEQERKELEKYNELERNRKIYQFTLYDRELNEVINQMERLDGDYNNTV 257

  Fly   234 HISAKYLKQCETLK-TVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIK 297
            :.|.:|:::.:..: .::....|:....|:.|..:|.:|.:.:..|:.:.:....::.:    ||
Yeast   258 YSSEQYIQELDKREDMIDQVSKKLSSIEASLKIKNATDLQQAKLRESEISQKLTNVNVK----IK 318

  Fly   298 NLETQLSAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIED--DERALAK--------KEADM 352
            :::.|:.:........:.:||..:..|:|.::|:.......::  .|.|:.|        |:.|:
Yeast   319 DVQQQIESNEEQRNLDSATLKEIKSIIEQRKQKLSKILPRYQELTKEEAMYKLQLASLQQKQRDL 383

  Fly   353 AKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLSTNENG---EASTLQEQLIVAKEQFSEAQT 414
            ...:||:...|..|.||:..:.:.: :|::..|.|:..|:.   :.::|::|.....|:..|...
Yeast   384 ILKKGEYARFKSKDERDTWIHSEIE-ELKSSIQNLNELESQLQMDRTSLRKQYSAIDEEIEELID 447

  Fly   415 TIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLVV--EIKNLERQLQSLDYEGGHFEK 477
            :|...:     |:|.|:..:.|     ..::| :||.:.|..  |:...|::||::
Yeast   448 SINGPD-----TKGQLEDFDSE-----LIHLK-QKLSESLDTRKELWRKEQKLQTV--------- 492

  Fly   478 LKQRRNDLHMRKRDLKRELDRCNASR-YDLQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQ 541
            |:...:|::..:|::...:.|..|:. .:::....:.......|.|.:|:|.:|.|...:.|.|
Yeast   493 LETLLSDVNQNQRNVNETMSRSLANGIINVKEITEKLKISPESVFGTLGELIKVNDKYKTCAEV- 556

  Fly   542 TAGGSLYSYVTDDDVTSKKILQRGNLQR----RVTLIPINKIQSGSLNRNVVEYAQNKVGAENVQ 602
            ..|.||:..|.|.:.|:..|:  ..|.|    |||.||:|::   ||:.: |::..|........
Yeast   557 IGGNSLFHIVVDTEETATLIM--NELYRMKGGRVTFIPLNRL---SLDSD-VKFPSNTTTQIQFT 615

  Fly   603 WAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLEGDVVDPHGTVSGG--- 664
            ..:..|.|:..:|..:|..||.|::.|||....:::...::|  ::||:||..|..|.::||
Yeast   616 PLIKKIKYEPRFEKAVKHVFGKTIVVKDLGQGLKLAKKHKLN--AITLDGDRADKRGVLTGGYLD 678

  Fly   665 -------AAPKGAN--------VLEELHAIKQIEKEYREIDSEIAQVEKQIASIEN--QALAFN- 711
                   .:.|..|        :||||..::   .|..:||::|.||...|..:.|  :::..|
Yeast   679 QHKRTRLESLKNLNESRSQHKKILEELDFVR---NELNDIDTKIDQVNGNIRKVSNDRESVLTNI 740

  Fly   712 -KMKENLDLRQHELTMCENRL-----------AQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQ 764
             ..:.:|:.:::|..:.|..|           ...||.|         |::.|.|..::...:.:
Yeast   741 EVYRTSLNTKKNEKLILEESLNAIILKLEKLNTNRTFAQ---------EKLNTFENDLLQEFDSE 796

  Fly   765 KTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFET---------- 819
            .:.:.|     .:|...    .:|::||.|::.:|....|...........|.|:
Yeast   797 LSKEEK-----ERLESL----TKEISAAHNKLNITSDALEGITTTIDSLNAELESKLIPQENDLE 852

  Fly   820 -------------LQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTE--- 868
                         ||.|:.|||...|:.:|||:..:..|...:.|:::|      .|.|...
Yeast   853 SKMSEVGDAFIFGLQDELKELQLEKESVEKQHENAVLELGTVQREIESL------IAEETNNKKL 911

  Fly   869 LEQAIKEQK---DKLRDQNKEMRNQLVKKEKMLKENQEIELEVKK--------KENEQKKISSDA 922
            ||:|..:|:   .||.:..|.:...::||..::...:|::..:::        ..|:...|:||
Yeast   912 LEKANNQQRLLLKKLDNFQKSVEKTMIKKTTLVTRREELQQRIREIGLLPEDALVNDFSDITSD- 975

  Fly   923 KEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIM 987
             :..:|:..:..:..         |:||.             ||
Yeast   976 -QLLQRLNDMNTEIS---------GLKNV-------------NK--------------------- 996

  Fly   988 VLDREEENFKE-TERRRNIVAM------DKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSS 1045
               |..||||: .|||:::...      .|:.|:.:|||:.:::.:.::....:|:.||..:|..
Yeast   997 ---RAFENFKKFNERRKDLAERASELDESKDSIQDLIVKLKQQKVNAVDSTFQKVSENFEAVFER 1058

  Fly  1046 LLPGAEAKLNPVH------------------------TNG-----CLTGLEIKVGFNGIWKESL- 1080
            |:|...||| .:|                        .||     ..||:.|.|.||....|.|
Yeast  1059 LVPRGTAKL-IIHRKNDNANDHDESIDVDMDAESNESQNGKDSEIMYTGVSISVSFNSKQNEQLH 1122

  Fly  1081 -GELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLK 1144
             .:||||||::.|::|:||:....||..|:.||:|||||..:...:.::||:...|:||:..:.:
Yeast  1123 VEQLSGGQKTVCAIALILAIQMVDPASFYLFDEIDAALDKQYRTAVATLLKELSKNAQFICTTFR 1187

  Fly  1145 DGLFNHANVLFRTLFEEGVSTITRQVSRQ 1173
            ..:...|:..||..:|..:||:. :|:|:
Yeast  1188 TDMLQVADKFFRVKYENKISTVI-EVNRE 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	302/1315 (23%)
SMC3	NP_012461.1	SMC_N	2..1208	CDD:426784	302/1318 (23%)