Protein Alignment SMC2 and SMC6

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_013487.1
• Gene: SMC6 / 851099
• SGDID: S000004375
• Length: 1114
• Species: Saccharomyces cerevisiae
• Alignment Length: 1233
• Identity: 255/1233 - (20%)
• Similarity: 497/1233 - (40%)
• Gaps: 318/1233 - (25%)

  Fly     2 YVKKLVLDGFKSYGRRTEIEGFDPEFTA----ITGLNGSGKSNILDSICFVLGISNLQNVRASAL 62
            |:||::|..|..:      |.|:.|..:    |.|.||||||.||.:|...||....:..|.|:|
Yeast    81 YIKKVILRNFMCH------EHFELELGSRLNFIVGNNGSGKSAILTAITIGLGAKASETNRGSSL 139

  Fly    63 QDLVYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLI---NGKLVQN 124
            :||:    :.|...|.:.:..||:......||... .||.|.|.:...|...|.:   |||.:.|
Yeast   140 KDLI----REGCYSAKIILHLDNSKYGAYQQGIFG-NEIIVERIIKRDGPASFSLRSENGKEISN 199

  Fly   125 KK-----VQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTL 184
            ||     |.|:|   .:.|:||...:.|...:..|             .|.|||.|.......||
Yeast   200 KKKDIQTVVDYF---SVPVSNPMCFLSQDAARSFL-------------TASTSQDKYSHFMKGTL 248

  Fly   185 IEKKETKVRETKVLLD---EEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETL 246
            :::....:.....:.|   |.:...|..|:..::.|::.:|:.|:::
Yeast   249 LQEITENLLYASAIHDSAQENMALHLENLKSLKAEYEDAKKLLRELN------------------ 295

  Fly   247 KTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEA 311
            :|.:.||.|:..:..:.....|.|....:::||.:..:||::| |:...|:|.:.::.     ..
Yeast   296 QTSDLNERKMLLQAKSLWIDVAHNTDACKNLENEISGIQQKVD-EVTEKIRNRQEKIE-----RY 354

  Fly   312 TATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDA 376
            |:.|:...|    |.|.|.|.:   |.:|.|...|::.  :..|:..||..|...|......:..
Yeast   355 TSDGTTIEA----QIDAKVIYV---NEKDSEHQNAREL--LRDVKSRFEKEKSNQAEAQSNIDQG 410

  Fly   377 QKKLEAVSQGLS------TNE-NGEASTLQ---EQLIVAKEQFSEAQTT-------IKTSEIELR 424
            :||::|:::.::      |.| .|:...::   |||..|.|:..|...:       :|..|.:::
Yeast   411 RKKVDALNKTIAHLEEELTKEMGGDKDQMRQELEQLEKANEKLREVNNSLVVSLQDVKNEERDIQ 475

  Fly   425 HTRGVLKQREGETQTNDAAYVKDKKLHDQLVVE---------IKNLERQLQSLDYEGGHFE---- 476
            |      :||.|.:|...: :::||:..|.:.:         .:|::|.|::::.....||
Yeast   476 H------ERESELRTISRS-IQNKKVELQNIAKGNDTFLMNFDRNMDRLLRTIEQRKNEFETPAI 533

  Fly   477 ----KLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSM 537
                .|...|.......|.::|.:   ::|.......:|:.|           :||  :|:..|.
Yeast   534 GPLGSLVTIRKGFEKWTRSIQRAI---SSSLNAFVVSNPKDN-----------RLF--RDIMRSC 582

  Fly   538 ALVQT-----------------AGGSLYSYVTDDDVTSKKILQ--RGNLQR--RVTLIPINKIQS 581
            .:...                 |.|: |..:.|....||..::  ..:|.|  |:.||.......
Yeast   583 GIRSNIPIVTYCLSQFDYSKGRAHGN-YPTIVDALEFSKPEIECLFVDLSRIERIVLIEDKNEAR 646

  Fly   582 GSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCR 646
            ..|.||.|          ||..|:||.|....::     ..||..:       ..::|..:|..:
Yeast   647 NFLQRNPV----------NVNMALSLRDRRSGFQ-----LSGGYRL-------DTVTYQDKIRLK 689

  Fly   647 SVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFN 711
                           ...::..|...|::|     ||:|.:|:.:...:.|::::.:.      :
Yeast   690 ---------------VNSSSDNGTQYLKDL-----IEQETKELQNIRDRYEEKLSEVR------S 728

  Fly   712 KMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEA 776
            ::|| :|.|   |...:|.:.:|.|:..:.                       |.:..|:||...
Yeast   729 RLKE-IDGR---LKSTKNEMRKTNFRMTEL-----------------------KMNVGKVVDTGI 766

  Fly   777 KLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEM 841
                        ||:..||    ::..|::.|:::..::|   |.|:|.::.:..:..|:|:
Yeast   767 ------------LNSKINE----RKNQEQAIASYEAAKEE---LGLKIEQIAQEAQPIKEQY--- 809

  Fly   842 IDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIEL 906
                       |:.|:....|..|:.:|::.|..::.|::....:......||:..|:..::||:
Yeast   810 -----------DSTKLALVEAQDELQQLKEDINSRQSKIQKYKDDTIYYEDKKKVYLENIKKIEV 863

  Fly   907 EVKK-KENEQKKI-SSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAK 969
            .|.. ||..|::| ::.|..:|:|:|.::     :|:              ::|:.....:|:::
Yeast   864 NVAALKEGIQRQIQNACAFCSKERIENVD-----LPD--------------TQEEIKRELDKVSR 909

  Fly   970 MQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLN----- 1029
            |.:|.:|.........|.:.::....:||.:::  .:.:| |.:.::...:...:|:..|
Yeast   910 MIQKAEKSLGLSQEEVIALFEKCRNKYKEGQKK--YMEID-EALNRLHNSLKARDQNYKNAEKGT 971

  Fly  1030 --------KAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGELSGG 1086
                    :|:.:|. .|||..|.:......::..:.||      :.|.       .::..||||
Yeast   972 CFDADMDFRASLKVR-KFSGNLSFIKDTKSLEIYILTTN------DEKA-------RNVDTLSGG 1022

  Fly  1087 QKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSML----KQHFTNSQFLIVSLKD 1145
            :||...::|:||..|...:.:..|||.|..:|..: :.||:.|    .:....:|.:|::.:|
Yeast  1023 EKSFSQMALLLATWKPMRSRIIALDEFDVFMDQVN-RKIGTTLIVKKLKDIARTQTIIITPQD 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	255/1233 (21%)
SMC6	NP_013487.1	P-loop containing Nucleoside Triphosphate Hydrolases	82..>237	CDD:476819	53/181 (29%)
		SMC_prok_B	107..953	CDD:274008	215/1053 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1006..1108	CDD:476819	24/93 (26%)