Protein Alignment SMC2 and SMC5

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_197096.1
• Gene: SMC5 / 831449
• AraportID: AT5G15920
• Length: 1053
• Species: Arabidopsis thaliana
• Alignment Length: 1156
• Identity: 218/1156 - (18%)
• Similarity: 439/1156 - (37%)
• Gaps: 295/1156 - (25%)

  Fly    30 ITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNGQAGITKATVTIVFDNTNPAQCPQG 94
            :.|.||||||:::.:|...||.......||:::...|.:...:|..|.::             :|
plant    48 VIGPNGSGKSSLVCAIALCLGGEPQLLGRATSVGAYVKRGEDSGYVKISL-------------RG 99

  Fly    95 YEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPK 159
            ..:...:::.|::....|::::.||..|..|.:.:......:.|||....:.|.::.:...:.|.
plant   100 NTREENLTIFRKIDTRNKSEWMFNGSTVSKKDIVEIIQKFNIQVNNLTQFLPQDRVCEFAKLTPV 164

  Fly   160 EVLSMVEEAAGTSQYKTKRDATKTLIEK-KETKVRETKVLLDEEVLPKLVKLRQERSAYQEYQKI 223
            ::|...|:|.|..|.....   :.|:|| ::.|..|..|..:.|.|.:|..|..|:.  ::.:::
plant   165 QLLEETEKAVGDPQLPVHH---RALVEKSRDLKQLERAVAKNGETLNQLKALVDEQE--KDVERV 224

  Fly   224 CRDIDFLIRIHISAKYL-------KQCETL---KTVEANEHKIEDRIANCKATHAKNLAEVESIE 278
            .:...||.::....|.|       |:.|.:   |.::..|.|:::.        ||||
plant   225 RQRELFLTKVDSMKKKLPWLKYDMKKAEYMDAKKRMKEAEKKLDEA--------AKNL------- 274

  Fly   279 NSVK---EMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIED 340
            ||:|   |.|::..||.....|.::..:.|..............|...:....|::....|..|.
plant   275 NSMKEPIEKQKKEKAETDSKCKKVKNLMDANGRNRCHLLEKEDEADARVVATYKELEELKKQEEH 339

  Fly   341 DERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQ---GLSTNENGEASTLQE-Q 401
            .:..:.|...|:...:.|.::|        ..||....|||.:|.   .|..:.||:.:..:: :
plant   340 RQERILKATEDLVAAERELQNL--------PVYERPVAKLEELSSQVTELHHSINGKKNQKEDNE 396

  Fly   402 LIVAKEQFSEAQTTIKTSEIELRHTRGVLK--QREGETQTNDA-AYVKD------KKLHDQLVVE 457
            .::::::::..|...|..::|..:.: :||  ...|..:..|| .:|:.      ::::..::||
plant   397 KLLSQKRYTLRQCVDKLKDMENANNK-LLKALANSGADRIFDAYQWVQQNRHEFKREVYGPVLVE 460

  Fly   458 IKNLERQLQSLDYEGGHF------EKLKQRRNDLHMRKRDLKRELDRCNASRYD---LQYQDPEP 513
            :....|  ::..:..||.      ..:.|...|..:..::||         |:|   |.|.....
plant   461 VNVPNR--ENACFLEGHVSFYIWKSFITQDPEDRDLLVKNLK---------RFDVPVLNYVGNSG 514

  Fly   514 N-------FDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRV 571
            |       .|:.:..|:..:|.|:.|..:::..|..:     .:..:|.....||..    ||..
plant   515 NQKAPFHISDQMRSLGIHARLDQIFDAPDAVKEVLNS-----QFGLEDSYIGSKITD----QRAE 570

  Fly   572 TLIPINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQ 636
            .:..:. |:......|...::.::.|..      |....|..|:..:..|            ...
plant   571 EVYKLG-IKDFWTPDNHYRWSSSRYGGH------SSASVDSVYQSRLLLC------------GVD 616

  Fly   637 ISYDPRINCRSVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIA 701
            :....::..|...||..::                .:||.|  |.::.|.|.::.|.|::.|:..
plant   617 VGELEKLRSRKEELEDSIL----------------FMEETH--KSLQTEQRRLEEEAAKLHKERE 663

  Fly   702 SIENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKT 766
            .|.|.:....|.:..|:.|               :||.:.::|       :|||:     |....
plant   664 EIVNVSYLEKKKRRELESR---------------YQQRKTKLE-------SLEQE-----EDMDA 701

  Fly   767 SQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLE--ITELQK 829
            |.||::| :|..|:|..|        |..|.:.|...|.....|...|:...:::||  |.|.:.
plant   702 SVAKLID-QASRANADRY--------TYAINLKKLLVEAVAHKWSYAEKHMASIELERKIRESEI 757

  Fly   830 SIETAKKQHQEMIDNLEKFKAELD-------ALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEM 887
            :|:..:|..|::...:|..|.|::       ..|.::.|.|:...||::...|....:.:....:
plant   758 NIKQYEKTAQQLSLAVEYCKKEVEGKQQRLATAKRDAESVATITPELKKEFMEMPTTVEELEAAI 822

  Fly   888 RNQLVKKEKMLKENQEIELEVKKKENE----QKKISSDAKE---AKKRMEALEAKYPWIPEEKNC 945
            ::.|.:...:|..|:.|..|.:.::::    ..|:.:|.::   ..|.:::|:.|  |:|..:..
plant   823 QDNLSQANSILFINENILQEYEHRQSQIYTISTKLETDKRDLSICMKEIDSLKEK--WLPTLRQL 885

  Fly   946 FGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDK 1010
            .|..|..:.:                                       ||:|       :|:..
plant   886 VGQINETFSH---------------------------------------NFQE-------MAVAG 904

  Fly  1011 EKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGI 1075
            |      |.:||.:.|                |...                  |:.|||.|
plant   905 E------VSLDERDTD----------------FDQY------------------GIHIKVKF--- 926

  Fly  1076 WKESLGEL--------SGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALD 1118
             :|| |:|        |||::|:..:..::::...:..|..::||::..:|
plant   927 -RES-GQLQVLSSHHQSGGERSVSTILYLVSLQDLTNCPFRVVDEINQGMD 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	218/1156 (19%)
SMC5	NP_197096.1	P-loop containing Nucleoside Triphosphate Hydrolases	21..>178	CDD:476819	31/142 (22%)
		SMC_N	23..890	CDD:481474	190/978 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<924..1026	CDD:476819	14/57 (25%)