Protein Alignment SMC2 and SMC1A

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_006297.2
• Gene: SMC1A / 8243
• HGNCID: 11111
• Length: 1233
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 58/313 - (18%)
• Similarity: 99/313 - (31%)
• Gaps: 116/313 - (37%)

  Fly   415 YEKMIQIDQ---NAPTEEE--HRAKGVTKPRYMV------------WRETISSTSTLGFRIEGIK 462
            :|.|..:|:   |.|.|.:  :..:...|..:|:            |..:......:.| :||.:
Human    86 FEFMWLVDEAKKNLPLELDFLNEGRNAEKVAHMLRHFDFLKVPQIHWELSTKRVLLMEF-VEGGQ 149

  Fly   463 KSDGTSSKDFKTTKSRDQI------C---EAFRE--FTDGFPHAMPKYIQRLKAIRATLEYSEFF 516
            .:|       :....::||      |   :.:.|  |.:||.|..|
Human   150 VND-------RAYMEKNQIDVNEISCHLGKMYSEMIFVNGFVHCDP------------------- 188

  Fly   517 KSHEVIGSSLLFVH-DRHKASVWLIDFAKTVALPESVAITHDSKWK--VGNHEDG-----YLIGI 573
              |.  |:.|:... |..||.:.|:|......|.|...:.:...|:  :....||     ..:|.
Human   189 --HP--GNVLVRKRPDTGKAEIVLLDHGLYQVLTEEFRLDYCHLWQSLIWTDMDGLKQYSQRLGA 249

  Fly   574 NNLIDIFSEVHDRQTLQCLTERIPRLSLPDDTNGIDANSDDPLRHDGCNRNSEISSAAVPAVPDR 638
            .:|..:|:         |:               :.|.|.|.::..       |..|.|.|..|.
Human   250 ADLYPLFA---------CM---------------LTARSWDSVKQG-------IGQAPVSATEDS 283

  Fly   639 CVDKIGCVNNNNNYDC-KPEDQQLVGN---------STADTSTGLRDCIGSSS 681
            .:        .||..| .||..||:.:         .|.|....:...:|:.|
Human   284 EI--------RNNAACYLPEISQLLNHVPRQMLLILKTNDLLRSIETTLGTRS 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	58/313 (19%)
SMC1A	NP_006297.2	SMC_N	3..1210	CDD:426784	58/313 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..308		7/31 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..369
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..966