Protein Alignment SMC2 and smc6

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_005158646.1
• Gene: smc6 / 797304
• ZFINID: ZDB-GENE-110303-1
• Length: 1094
• Species: Danio rerio
• Alignment Length: 1200
• Identity: 242/1200 - (20%)
• Similarity: 493/1200 - (41%)
• Gaps: 258/1200 - (21%)

  Fly     3 VKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVY 67
            ::.:.|..|.|:.....:: |......|.|.||:|||.||.::...||.......|.::|:..|
Zfish    65 IESITLRNFMSHHLLGPLK-FGANVNFIVGNNGTGKSAILTALIVGLGGKATTTNRGTSLKGFV- 127

  Fly    68 KNGQAGITKATVTIVFDNTNPAQCPQGYEKCR------EISVTRQVVVGG------KNKFLINGK 120
               :.|.|...:.:...|       :|.:..:      .|.:..::...|      |||   .|.
Zfish   128 ---KYGETSTDIKVKLKN-------RGNDPYKGDVYGDSICIEHRITSDGCRTCKIKNK---AGH 179

  Fly   121 LVQNKK-----VQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDA 180
            :|..||     :.|.|   .:.|:||..::.|...:|.|:.|.:           ..:|:....|
Zfish   180 VVSTKKEELTAILDHF---GIQVDNPVSVLNQEMSKQFLHSKSE-----------ADKYRFFMKA 230

  Fly   181 TKTLIEKKE---TKVRETKVLLDEEVLPKLVKLRQERSAYQEYQKIC-RDIDFLIRIHISAKYLK 241
              ||:|:.:   ..:::||.:..::|               |.|:.| ||   |.::.:..|  :
Zfish   231 --TLLEQMKRDYIHIKQTKAVTRDQV---------------ERQEECLRD---LRQLFLQRK--E 273

  Fly   242 QCETLKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAK 306
            :.|.:.:::.....:||    .|...|.:|  |...|:.|:::::||:.|........:.||...
Zfish   274 RYERMSSLDDMRQTLED----LKKKMAWSL--VREKESQVEQLKEQIEKEDADCKHEEKLQLCQN 332

  Fly   307 RALEATATGSLKAAQG---TIQQDEKKIRMASKNIEDD----ERALAKKEADMAKVQGEFESLKE 364
            :.  |.|...|:.:|.   |::::::.:...|:.::::    .:|...:|....:.:.:.:.||:
Zfish   333 KV--AVAEKKLQDSQKHLCTLREEQEHLTEESRKMKEEIKVKTKAQKSQEVVYFRAENKLKQLKK 395

  Fly   365 ADARDSKAYEDAQKKLEAVSQGLSTNENGEASTLQ--EQLIVAKEQFSEAQTTIKTSEIELRHTR 427
            ....       .|:::..:|.|.|.|.. ||..:|  :::...|.|..:.:|       |.|...
Zfish   396 EQCL-------LQERIHKISHGSSRNRQ-EAEHMQHLKKISALKNQLEKLET-------ESRALN 445

  Fly   428 GVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDL 492
            ..:|.|:       .|..|.::.:|:|.:|.||::..|:|         |.|:::..:..|...|
Zfish   446 QEIKDRQ-------QALHKGREEYDKLSMEEKNIKASLES---------KSKRKKQLMASRSNRL 494

  Fly   493 KRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVT 557
            :|..|........:.....:..|.::.| |.:|....:||...::|:....|..|.|:.. |:..
Zfish   495 RRFGDHMPELMESINKAFAQGRFKKKPV-GPIGACISLKDPTLTLAVECCLGFFLKSFCC-DNYK 557

  Fly   558 SKKILQ--------RGNLQRRVTLIP----INKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDY 610
            .:|:||        :|| :.::.:.|    :..:|...::........:.:..||...|..|||.
Zfish   558 DEKVLQGLMSQYFYKGN-RPQIMVCPFTDHVYNLQGRGVHHPEFPSVLDCLNIENPVIANCLIDM 621

  Fly   611 DRYYEPVMKFCFGGTLICKDLIVAKQI---SYDPRINCR-SVTLEGDVVDPHGTVSGGAAPKGAN 671
             |..|.:        |:.::...|:::   |..|: ||| :.|.:||.|..:...:    |:...
Zfish   622 -RSIESI--------LVIREKARARKVMQGSRPPK-NCREAFTADGDQVFTNRYYT----PEHEV 672

  Fly   672 VLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFN----KMKENLDLRQHELTMCENRLA 732
            :::.|..         :.::||:.|..::.:|:.|.|.|.    .:||::.|.:.:|     |..
Zfish   673 LVKYLGG---------DPEAEISLVNGELENIQAQLLRFQLHSCSVKEDIQLMEEKL-----RSV 723

  Fly   733 QTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIK 797
            ....::||..|.:::..:..||                  :||..       ::.::::...|.:
Zfish   724 IMACKKNQESINKVKASITELE------------------NIEEA-------QDEDISSLEEEAQ 763

  Fly   798 VTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSA 862
            ..:|:.|..:...|:.|.       |:.:.:|.:....::.:::...:||...|::.||.....|
Zfish   764 ENEQKIELEKRIVKEAED-------ELRKHEKGLLAVNQKFKDVKCKMEKLSDEMEQLKEEQVKA 821

  Fly   863 ASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIELEVKKKE--NEQKKISSDAKEA 925
            .:...:|:|.:|..:.||:|....:  |.:|::..|:|....:.|.|.:|  .|::::....:..
Zfish   822 ETVCNKLDQTMKTLEKKLKDHQNNI--QSMKEDLSLQEEDLRDCEAKARELCPERQQVDQSPRSI 884

  Fly   926 KKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLD 990
            ...:..|..|   |..::|..|.|.   ...:|......|..:|..:.:|..:....::.||: |
Zfish   885 DVEITRLRQK---IKTQENSHGDKE---QIIREYAEAHSNYKSKSSQLRDLRKFIDRLDNIMI-D 942

  Fly   991 REEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEV--NTNFSGIFSSLLPGAEAK 1053
            | ::.:|..  |:::....|......::        ||:...:.:  :.|.:...|...||.|
Zfish   943 R-QDRYKTL--RKSLSVRCKLYFNNFMI--------QLHCCGSMMFDHNNETLSISVKPPGQE-- 994

  Fly  1054 LNPVHTNGCLTGLEIKVGFNGIWKESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALD 1118
            :|.|                    ..:..||||::|...:..:||:.:.:.:|...|||.|..:|
Zfish   995 MNSV--------------------SDMRSLSGGERSFSTVCFILALWEITESPFRCLDEFDVYMD 1039

  Fly  1119 MSHTQNIG-SML-----KQHFTNSQFLIVS 1142
            | |.::|. :||     :||.  .||:.::
Zfish  1040 M-HNRSISMNMLVALSERQHL--RQFIFIT 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	242/1199 (20%)
smc6	XP_005158646.1	P-loop containing Nucleoside Triphosphate Hydrolases	65..>221	CDD:476819	40/184 (22%)
		SMC_prok_B	<242..1066	CDD:274008	197/990 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<996..1091	CDD:476819	24/93 (26%)