Protein Alignment SMC2 and Smc4

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_598547.1
• Gene: Smc4 / 70099
• MGIID: 1917349
• Length: 1286
• Species: Mus musculus
• Alignment Length: 1294
• Identity: 285/1294 - (22%)
• Similarity: 538/1294 - (41%)
• Gaps: 265/1294 - (20%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            :.:..:|...||||.....:..|...|:.|.|.|||||||::||:.||.|. ..|.:|:..|..|
Mouse    80 LMITHIVNQNFKSYAGEKVLGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKLSVL 143

  Fly    66 VYKNGQ-AGITKATVTIVFDNTNPAQCPQGYEKC--REISVTRQVVVGGKNKFLINGKLVQNKKV 127
            ::.:.: ..|...||.:.|......: ...||..  ....|:|.......:.:.|:||....|.|
Mouse   144 IHNSDEHKDIQSCTVEVHFQKIIDKE-GDDYEVLPNSNFYVSRTAYRDSTSVYHISGKKKTFKDV 207

  Fly   128 QDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKV 192
            .:...|..:::::..|||:||:::|:..||||   ...|...|..:|.........|.|..:...
Mouse   208 GNLLRSHGIDLDHNRFLILQGEVEQIAMMKPK---GQTEHDEGMLEYLEDIIGCGRLNEPIKVLC 269

  Fly   193 RETKVLLDE--EVLPKLVKLRQERSAYQEYQKICRDIDFLI--------RIHISAKYLKQCET-L 246
            |..::|.:.  |.|.::..:.:|:.|.:..:.|.  |:||.        :.||...|:...:. :
Mouse   270 RRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIA--IEFLTLENEMFKKKNHICQYYIYDLQNRI 332

  Fly   247 KTVEANEHKI-EDR---------IANCKATHAKNLA--EVESIENSV-------KEMQQQIDAE- 291
            ..:...:.|| ||.         ::|  ...|||.|  :||...|.|       ||...|:|.|
Mouse   333 AEITTQKEKIHEDTKEITEKSNVLSN--EMKAKNSAVKDVEKKLNKVTKFIEQNKEKFTQLDLED 395

  Fly   292 ---------MGGSIKNLETQL---------------SAKRALEATAT--GSLKAAQGTIQQDEKK 330
                     .....|.||.||               .:|..:..|.|  .||:..:   :::|||
Mouse   396 VQVREKLKHATSKAKKLEKQLQKDKEKVEELKSVPAKSKTVINETTTRNNSLEKER---EKEEKK 457

  Fly   331 IRMASKNIEDDERALAK-KEADMAKVQGEFESLKEADARDSKAYEDAQKKLE--------AVSQG 386
            ::....:::.:.:.|.| ||....::.|..:|:.||.::    .|.||.:|:        ||||
Mouse   458 LKEVMDSLKQETQGLQKEKEIQEKELMGFNKSVNEARSK----MEVAQSELDIYLSRHNTAVSQ- 517

  Fly   387 LSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLH 451
                    .|..:|.||.|.|...|.:..||....:|..|:..||::|.|.|          ||
Mouse   518 --------LSKAKEALITASETLKERKAAIKDINTKLPQTQQELKEKEKELQ----------KL- 563

  Fly   452 DQLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFD 516
            .|..:.:|:|...|         |:|:::.::.|.|         :|......|...|:.:..
Mouse   564 TQEEINLKSLVHDL---------FQKVEEAKSSLAM---------NRSRGKVLDAIIQEKKSG-- 608

  Fly   517 RRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKK----ILQRGNLQRRVTLIPIN 577
              ::.|:.|:|..:..:.....:..::......|:..|.:.:.:    .|::.|: ...|.|.::
Mouse   609 --RIPGIYGRLGDLGAIDEKYDIAISSCCHALDYIVVDSIDTAQECVNFLKKHNI-GIATFIGLD 670

  Fly   578 KIQSGSLNRNVVEYAQN--------KVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVA 634
            |:...:...:.::..:|        ||..|.::.|        :|     |....||:..:|..|
Mouse   671 KMTVWAKKMSKIQTPENTPRLFDLVKVKNEEIRQA--------FY-----FALRDTLVANNLDQA 722

  Fly   635 KQISYDPRINCRSVTLEGDVVDPHGTVSGGAAP-----KGANVLEELHAIKQIEKEYREIDSEIA 694
            .:::|......|.|||:|.:::..||:|||.:.     .|::|::|: :::::.|    ::|::.
Mouse   723 TRVAYQRDRRWRVVTLQGQIIEQSGTMSGGGSKVMRGRMGSSVIDEI-SVEEVNK----MESQLE 782

  Fly   695 QVEKQIASIENQALAFNKMKENLDLRQHELTMCENRLAQ----TTFQQNQAEIEEMRE------- 748
            :..||...|:.|.:            |||..:.:.|.::    .|.::..|.|:.:.|
Mouse   783 RHSKQAMQIQEQKV------------QHEEAVVKLRHSERDMRNTLEKFAASIQGLSEQEEYLCV 835

  Fly   749 RVKTLEQQIIDS---REKQKTSQAKIVDIEAK---LADAKGYRERELNAATNEIKVTKQRAEKSR 807
            ::|.||..::.:   |::||..:..:...:.:   :|:..|..|.|:....|.|.....|..|::
Mouse   836 QIKELEANVLTTAPDRKQQKLLEENVSVFKKEYDAVAEKAGKVEAEIKRLHNTIIDINNRKLKAQ 900

  Fly   808 ANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQA 872
                                |..::|..||..|....:.|.:..:.....|...|...|...|:.
Mouse   901 --------------------QNKLDTINKQLDECASAITKAQVAIKTADRNLKKAQDSVCRTEKE 945

  Fly   873 IKEQKDKLRDQNKEMRNQLVKKEKML--------------KENQEIELEVKKKENEQKKISSDAK 923
            ||:.:.::.|...|::|...|.|:::              ||::.:..|:|..:..:..:..||.
Mouse   946 IKDTEKEINDLKTELKNIEDKAEEVINNTKTAETSLPEIQKEHRNLLQELKVIQENEHALQKDAL 1010

  Fly   924 EAKKRMEALEA---------KYPW---------IPEEKNCFGMKNTRYDYSKED------PHEAG 964
            ..|.::|.::.         || |         .|.|.|   ...|....|:|:      |....
Mouse  1011 SIKLKLEQIDGHISEHNSKIKY-WQKEISKIKLHPVEDN---PVETVAVLSQEELEAIKNPESIT 1071

  Fly   965 NKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLN 1029
            |::|.::.:..:|:.  |:.||....::|:.:.:.....:.:..:::..::....:.::..::..
Mouse  1072 NEIALLEAQCREMKP--NLGAIAEYKKKEDLYLQRVAELDKITSERDNFRQAYEDLRKQRLNEFM 1134

  Fly  1030 KAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFN-----GIWKESLGELSGGQKS 1089
            .....:.......:..|..|.:|:|..|.:   |......:.|:     ..||: :..||||:|:
Mouse  1135 AGFYVITNKLKENYQMLTLGGDAELELVDS---LDPFSEGIMFSVRPPKKSWKK-IFNLSGGEKT 1195

  Fly  1090 LVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLF 1148
            |.:|:||.|:..:.|.|||.:||:|||||..:...:...:.:...|:||:|:||::.:|
Mouse  1196 LSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMF 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	285/1293 (22%)
Smc4	NP_598547.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51
		SMC_N	81..1272	CDD:426784	285/1293 (22%)