Protein Alignment SMC2 and Smc6

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_079971.2
• Gene: Smc6 / 67241
• MGIID: 1914491
• Length: 1097
• Species: Mus musculus
• Alignment Length: 1244
• Identity: 265/1244 - (21%)
• Similarity: 474/1244 - (38%)
• Gaps: 318/1244 - (25%)

  Fly    23 FDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNGQAGITKATVTIVFDNTN 87
            |......:.|.||||||.:|.::...||...:...|.|:|:..|    :||...|.::|...|
Mouse    73 FGSNVNFVVGNNGSGKSAVLTALIVGLGGKAVATNRGSSLKGFV----KAGQNSADISITLRN-- 131

  Fly    88 PAQCPQGYEKCR------EISVTRQVVVGGKNKFLI---NGKLVQNKK-----VQDFFCSIQLNV 138
                 :|.:..|      .|.|.:.:.|.|...:.:   .|.:|..:|     :.|.|   .:.|
Mouse   132 -----RGDDAFRANVYGDSIVVQQHISVDGSRSYKLKSEKGTVVSTRKEELIAILDHF---NIQV 188

  Fly   139 NNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKE--TKVRETKVLLDE 201
            :||..::.|...:|.|..|.:           ..:||....||: |.:.||  :.:.|||....|
Mouse   189 DNPVSVLTQEMSKQFLQSKNE-----------GDKYKFFMKATQ-LEQMKEDYSYIMETKERTKE 241

  Fly   202 EVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKAT 266
            ::       .|......|.::.|.:                                     |..
Mouse   242 QI-------NQGEERLTELKRQCLE-------------------------------------KEE 262

  Fly   267 HAKNLAEVESIENSVKEMQQQIDAEMGGSIKN-LETQLSAKRALEATATGSLKAAQGTIQQDEKK 330
            ..:|:|.:.:::.:::.::.    ||..::.| :|.||:|.|
Mouse   263 RFQNIAGLSTMKTNLEYLKH----EMAWAVVNEIEKQLNAIR----------------------- 300

  Fly   331 IRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLSTNENG-E 394
                 .||:..|...||.:..|     |.:.::..||  .|.|:|.|.|||.:|:  .||... |
Mouse   301 -----DNIKIGEERAAKLDRKM-----EEQQVRLNDA--EKKYKDIQDKLEKISE--ETNARAPE 351

  Fly   395 ASTLQEQLIVAKEQFSEAQTTIKTSEIE---LRHTRGVLKQREGETQTNDAAYVKDKKLHDQ--- 453
            ...|:..:|.....|::|:.....|..|   |:.....|.:|..|.:.:....::.::|..|
Mouse   352 CMALKTDVIARTRAFNDAEVLYNRSLNEYKALKKDGEQLCKRIEELKKSTDQSLEPERLERQKRI 416

  Fly   454 --LVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLH--MRKRDL---------KRELDRCNASRYD 505
              |..::|.|:.|..:::.|...||:..::....|  :||.|:         :|:|.....|:.|
Mouse   417 CWLKEKVKALQDQEHTVNQEAEQFEQAIEKDKQEHGRVRKEDIEVRHALNYNQRQLKELKDSKTD 481

  Fly   506 -LQYQDP---------EPNFDRR----KVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYV----T 552
             |:...|         :..:.||    |..|.:|....::|.:.::|:.....|.|.:|.    .
Mouse   482 RLKRFGPHVPALLEAIDDAYRRRQFTHKPIGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHA 546

  Fly   553 DDDVTS---KKILQRGNLQRRVTLI----PINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDY 610
            |:.|..   ||....|..:.::.:.    .:..::..:............:..:|...|.||||.
Mouse   547 DERVLQSLMKKFYPPGTSRPQIIVSEFRDEVYDVRLRAAYHPEFPTVLTALEIDNAVVANSLIDM 611

  Fly   611 DRYYEPVMKFCFGGTLICKDLIVAKQI--SYDPRINCR-SVTLEGDVVDPHGTVSG-GAAPKGAN 671
             |..|.|        |:.|:..||:.:  |..|..||| :.|.:||.|......|. ...||..:
Mouse   612 -RSIETV--------LLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSESTRPKFLS 667

  Fly   672 VLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNKMKENL--DLRQHE--LTMCENRLA 732
                           |::||||:.:|.:|.:.:...:...:....|  |::::|  |..|
Mouse   668 ---------------RDVDSEISDLETEIENKKGHIITLQQRLSALEKDIKRNEELLKRC----- 712

  Fly   733 QTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIK 797
                   |...:|::.:::   :.|.:.||.:...:.:.||| |.|.|         .|..|:||
Mouse   713 -------QLHYKEIKMKIR---KNISEIRELENIEEHQSVDI-ATLED---------EAEENKIK 757

  Fly   798 VTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSA 862
            :  |..||:....|:..:..::|::|......:|:....|..|:.|.|:      |.|.:..|..
Mouse   758 M--QMVEKNMEQQKENMENLKSLKIEAENKYDTIKLKINQLSELADPLK------DELNLADSEV 814

  Fly   863 ASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKK 927
            .|:        |..|....|:.||..:.|.||.:        ||::|:|| .|:|:|...:...:
Mouse   815 DSQ--------KRGKQHYEDKQKEHLDTLNKKRR--------ELDMKEKE-LQEKMSQARQICPE 862

  Fly   928 RMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKK-DKMERTLNMNAIMVLDR 991
            |:|.                                 .|.|.:.:|: :::.:.:........||
Mouse   863 RIEV---------------------------------KKSASILDKEINRLRQKIQAEHASHGDR 894

  Fly   992 EEENFKETERRRNIVAMD-KEKIKKIIVKMDEEEQDQLNKAATE----VNTNFSGIFSSLLPGAE 1051
            ||...:..|.|...:.:| |.:..:..:|:.||......|...:    :.......|.:||....
Mouse   895 EEIMKQYQEARETYLDLDNKVRTLRRFIKLLEEIMTHRYKTYQQFRRCLTLRCKLYFDNLLSQRA 959

  Fly  1052 --AKLNPVHTNGCLT-----GLEIKVGFNGIWKESLGELSGGQKSLVALSLVLAMLKFSPAPLYI 1109
              .|:|..|.|..|:     |...|..||     .:..||||::|...:..:|::...:.:|...
Mouse   960 YCGKMNFDHKNETLSITVQPGEGNKASFN-----DMRALSGGERSFSTVCFILSLWSIAESPFRC 1019

  Fly  1110 LDEVDAALDMSHTQNIGSML-----KQHFTNSQFLIVSLKDGLFNHANVLFRTLF----EEGVST 1165
            |||.|..:||.:.:....|:     .|.|  .||::::.:......::.|.|.|.    |.|.:|
Mouse  1020 LDEFDVYMDMVNRRIAMDMILKMADSQRF--RQFILLTPQSMSSLPSSKLIRILRMSDPERGQTT 1082

  Fly  1166 IT-RQVSRQ 1173
            :. |.|:::
Mouse  1083 LPFRPVTQE 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	261/1230 (21%)
Smc6	NP_079971.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		P-loop containing Nucleoside Triphosphate Hydrolases	54..>210	CDD:476819	38/161 (24%)
		SMC_prok_B	<221..1055	CDD:274008	215/1033 (21%)
		Flexible hinge	458..667		47/217 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	813..839		8/33 (24%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<983..1081	CDD:476819	26/104 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1078..1097		4/14 (29%)