Protein Alignment SMC2 and Smc2

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001102136.2
• Gene: Smc2 / 362519
• RGDID: 1305227
• Length: 1191
• Species: Rattus norvegicus
• Alignment Length: 1176
• Identity: 483/1176 - (41%)
• Similarity: 763/1176 - (64%)
• Gaps: 4/1176 - (0%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            ||||.::|:|||||.:|||:.||||.|.|||||||||||||||||||:||||||..||||.||||
  Rat     1 MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDL 65

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            ||||||||||||:|:|.|||::..|.|.|:|...||:||||||:||:||:||||....|.:|||.
  Rat    66 VYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQDL 130

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            |||:.||||||:||||||:|.:||||||.|:|||:||||||..|:.|:.|.:..|||||.|::|.
  Rat   131 FCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEI 195

  Fly   196 KVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHK-IEDR 259
            |.:|:||:.|.:.||::|||:|.||||:.|:|:.|.|::|:.::| ..|..|...|.|.| ::|:
  Rat   196 KTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL-LAEDTKERSAGELKEMQDK 259

  Fly   260 IANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTI 324
            |...:...::|..:::::...::|::::.|.|.||.:::||...:..:.:...:..:....:..:
  Rat   260 ILKLQEVLSENEKKIKALNCEIEELEKRKDKETGGILRSLEDAFAEAQRVNTKSQSAFDLKKKNL 324

  Fly   325 QQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLST 389
            ..:|.|.:...||:.:|.:|||.||.::.|:......|:||..:|::|...||:...|||.|||:
  Rat   325 ASEETKRKELEKNMAEDSKALAAKEKEVKKLTDGLHGLQEASNKDAEALAAAQQHFNAVSAGLSS 389

  Fly   390 NENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQL 454
            ||:|..:||..|::..|...|:|||..|.::::|:|.:..||.::.|.:..|:.|.||::..:.:
  Rat   390 NEDGAEATLAGQMMACKNDISKAQTGAKQAQMKLKHAQQELKNKQAEVRKMDSGYKKDQEAFEAV 454

  Fly   455 VVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQ--YQDPEPNFDR 517
            ....:.||.:::.|:||....|:|.::...:.....:||...:...|...:|:  |:|||.|::|
  Rat   455 KKVKEKLETEMKKLNYEDNKEERLLEKHRQVSRDISNLKGTYEALLAKFPNLRFAYKDPEKNWNR 519

  Fly   518 RKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRVTLIPINKIQSG 582
            ..|:|||..|..|||...:.||...||..||:.|.|.:||.||:|::|.|:||.|:||:|||.:.
  Rat   520 NCVKGLVASLINVKDNSTATALELVAGERLYNVVVDTEVTGKKLLEKGELKRRYTIIPLNKISAR 584

  Fly   583 SLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRS 647
            .:....:..|||.||..||..|:||:||....:..|:|.||.|.:|.::..||::::|.||..|:
  Rat   585 CIAPETLRVAQNLVGPNNVHVALSLVDYKPELQKAMEFVFGTTFVCNNMDNAKKVAFDKRIMTRT 649

  Fly   648 VTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNK 712
            |||.|||.|||||:||||..:.|::|.:...:|.::.|.|..:.|:..:|:::|.::|.|..:.:
  Rat   650 VTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQAELRTKEKELQALEEELAGLKNVAEKYRQ 714

  Fly   713 MKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAK 777
            :|:..:::..|..:.:.:|.|:::.:.|.|::.:::.::..|:.:.:::|.||.::.|...:|.|
  Rat   715 LKQQWEMKTEEGDLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQKKAEEKYEALENK 779

  Fly   778 LADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMI 842
            :.:|:..||:||..|..::...|.:|:.|....|:::||.|.:.||:.||::...:.::|...:.
  Rat   780 MKNAEAEREKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHASNEQQLDAVN 844

  Fly   843 DNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIELE 907
            :.::.::.:::.:....:.....|.:.:..:.:||:.:..|:..::::..:..|...:|.:.:|:
  Rat   845 EAIKAYEGQIEIMAAEVAKNKESVNKAQNELMKQKEIISAQDNIIKDKCAEVAKHNLQNNDSQLK 909

  Fly   908 VKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQE 972
            :|:.::...|...:|.:|..::..:...|.||..||:.||..|:.||:...:|.|||.:|.|:||
  Rat   910 IKELDHSISKHKREADDAAAKVSKMLNDYDWINAEKHLFGQPNSAYDFKTNNPKEAGQRLQKLQE 974

  Fly   973 KKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNT 1037
            .|:|:.|.:||.|:.||...||.:.:..:::.||..||.||...|..:|:::...||.|..:||.
  Rat   975 VKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQKKNQALNIAWQKVNK 1039

  Fly  1038 NFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGELSGGQKSLVALSLVLAMLKF 1102
            :|..|||:|||||.|.|.|......|.|||.||.....|||:|.||||||:|||||||:|:||.|
  Rat  1040 DFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSMLLF 1104

  Fly  1103 SPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTLFEEGVSTIT 1167
            .|||:|||||||||||:|||||||.||:.|||:|||::||||:|:||:|||||:|.|.:||||:.
  Rat  1105 KPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVLFKTKFVDGVSTVA 1169

  Fly  1168 RQVSRQ 1173
            |....|
  Rat  1170 RFTQSQ 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	476/1162 (41%)
Smc2	NP_001102136.2	SMC_N	2..1167	CDD:426784	478/1165 (41%)