Protein Alignment SMC2 and SMC5

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Alignment Length: 1251
• Identity: 244/1251 - (19%)
• Similarity: 445/1251 - (35%)
• Gaps: 375/1251 - (29%)

  Fly    11 FKSYGRRTEIEGFDPE--FTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNGQAG 73
            |.||...|    |.|:  ...:||.||||||.|:.:|...||...:...|::::.|.:    |:.
  Fly    24 FVSYSEIT----FHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYI----QSN 80

  Fly    74 ITKATVTI-VFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDFFCSIQLN 137
            .|.||:.: |:..|     |...|..|.|     :...|.:.|.:|.|....|.......|..:.
  Fly    81 KTSATIIVRVYGRT-----PNTTETFRRI-----INSNGLSTFSVNDKDTSKKNFLAAVSSFNIQ 135

  Fly   138 VNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETKVLLDEE 202
            |:|....:.|.::|....|.|:|:|      ..|.......|...:....|:.:..:..|..:.|
  Fly   136 VSNLCQFLPQDRVQDFSKMNPQELL------LNTMSSVCDEDLINSFNSLKQMRTEQANVHANRE 194

  Fly   203 VLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKATH 267
                     :|:|...:.||....:...:..:...:.:||  .|:...|.:..:|.:....||
  Fly   195 ---------KEKSDLVKKQKRLEHLQMTVSQYKEREEVKQ--KLQVYSAKKLWVETQAGEAKA-- 246

  Fly   268 AKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQQDEKKIR 332
                                  |||...:||.:||....:    .....|..:|..|:::::.:|
  Fly   247 ----------------------AEMKTQVKNAKTQSDKLK----NQHDKLLQSQEQIEKEKESLR 285

  Fly   333 MASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVS------QGLSTNE 391
               |.:.:..|.|....|:.|.:.|:.:|||:...:.....|...||....:      ..|..|:
  Fly   286 ---KALLEKTRLLENAVAEKAAIDGKMDSLKQGIYQKKYELEQNIKKSRRTATECDNLNQLVENK 347

  Fly   392 NGEASTLQEQ--LIVAK-EQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQ 453
            ..|..||.:.  |||:: |:..|:....:...:|....|..|:|                ||:|:
  Fly   348 IYELETLNKSRPLIVSELERAKESCAAARGKAMEQYSRRRQLEQ----------------KLNDE 396

  Fly   454 LVVEIK----NLER----QLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQD 510
            ::.||.    .:||    ::|.:|       :::.:..:|.:....|.:     |..||.|...|
  Fly   397 MIPEITAYKLKIERLRNVKMQKID-------EIRAKNPNLVVAMNWLAQ-----NKQRYKLNVYD 449

  Fly   511 P-------EPNFDRRKVRGLVGK--LF--------QVKDMQNSMALVQTAG-GSLYSYVTDDDVT 557
            |       :.:.|.:.:..:|.:  ||        .:.|:.|.:.:.|..| ..:|...:|..|.
  Fly   450 PMILELTVQNHEDAKFLENVVAQRDLFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVY 514

  Fly   558 SKKILQRGNLQRRVTLIPINKIQSGSLNRNVVEYAQ------NKVGA----ENVQWAMSLI-DYD 611
            |.|             .||:.::|......:|:...      ||:.|    .|:......: :|.
  Fly   515 SPK-------------TPIDDLRSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGTEAVGNYT 566

  Fly   612 RYYEPVMKFCFGG--------------TLICKDLIVAKQ--ISYDPR------INCRSVTLEGDV 654
            ......::..|||              |::.:..|.||.  |:.|.:      ..|.....|.|.
  Fly   567 SSIPKAIRVYFGGSKKFVVTASRYRSDTILTESSIRAKNQLITVDSQQLALVMKQCSEAVKESDS 631

  Fly   655 VDPHGTVSGGAAPKGANVLEELHAIKQIEKE-YREIDSEIAQVEKQIASIENQALAFNKMKENLD 718
            :.       .|..:..|..|.|.|:.:.|:| .|::|.:||.              ||.:|..::
  Fly   632 IK-------NAITQTDNEFERLQAVAKDEQEKRRKLDQKIAH--------------FNSLKTEIE 675

  Fly   719 LRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKG 783
            ..|.:|....|                 .:.:..||....:|..|   ...||.|.:|:|.....
  Fly   676 TLQKKLEALRN-----------------SDSLDCLETNFCNSLHK---DLKKIFDADAELCSCLK 720

  Fly   784 YRER---ELNAA-----------TNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQK----- 829
            ..:|   |.|.|           ..:|:..|:..|:|:|..:..:|..:.|:.:|:::.|
  Fly   721 AIDRLIIEKNMAQTKVSIYMLQHETQIEALKESEEQSKAATRDFQQLLQCLENQISDVNKRKSAI 785

  Fly   830 ------SIETA-----KKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQ 883
                  .|.|:     ||:.:| ::|:                   ::.||.:||.:.:.:|
  Fly   786 QGLCHGEIPTSSKFPFKKEFRE-LENI-------------------DLPELREAIHDFQARL--- 827

  Fly   884 NKEMRNQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGM 948
                       |.|...|.|.....:..:||.|::....:|:..:.:::|:            ||
  Fly   828 -----------ECMKSVNSEAISSYQGLQNEVKQLEEGIQESVNQAKSIES------------GM 869

  Fly   949 KNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKI 1013
            .|.   |.|.:|
  Fly   870 SNL---YDKWEP----------------------------------------------------- 878

  Fly  1014 KKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLT-GLEIKVGF-NGIW 1076
                         :||.....::|.||....|:....|..|:........: |::|.|.| .|:.
  Fly   879 -------------KLNSLVETISTKFSEFMESIEYVGEVVLSKTDKYDFDSYGIQIMVQFRRGLQ 930

  Fly  1077 KESLGEL--SGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFT---NS 1136
            .:.|.:.  |||::::......|::...:..|...:||::..:|.::.::|..:|.:..|   ::
  Fly   931 LQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSA 995

  Fly  1137 QFLIVS---LKDGLFN 1149
            |:|.|:   |:|..:|
  Fly   996 QYLFVTPKLLRDLNYN 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	244/1251 (20%)
SMC5	NP_996141.2	P-loop containing Nucleoside Triphosphate Hydrolases	14..>160	CDD:476819	43/153 (28%)
		SMC_N	22..>425	CDD:481474	106/489 (22%)
		SMC_prok_B	<193..1001	CDD:274008	192/1046 (18%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<919..1025	CDD:476819	22/93 (24%)