Protein Alignment SMC2 and smc3

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_999854.1
• Gene: smc3 / 324475
• ZFINID: ZDB-GENE-030131-3196
• Length: 1216
• Species: Danio rerio
• Alignment Length: 1342
• Identity: 311/1342 - (23%)
• Similarity: 575/1342 - (42%)
• Gaps: 305/1342 - (22%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            ||:|::::.||:||..:|.::.|..:...|.|.|||||||...:|.|||. ....::|......|
Zfish     1 MYIKQVIIQGFRSYRDQTVVDPFGSKHNVIVGRNGSGKSNFFYAIQFVLS-DEFSHLRPEQRLAL 64

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            :::.....:..|.|.|:|||:: .:.|...|   |:|: |:|:...|:::.::.|:|....|.:.
Zfish    65 LHEGTGPRVISAFVEIIFDNSD-NRLPIDKE---EVSL-RRVIGAKKDQYFLDKKMVTKNDVMNL 124

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            ..|...:.:||.:::.||||.|:......:.|.::.|.|||..|..:::.:.:|:::.|.|..:.
Zfish   125 LESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKI 189

  Fly   196 KVLLD--EEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIE- 257
            ..||.  ||.|..|...::|.:.||::.|:.|.:::               |:...|.||.:.:
Zfish   190 NELLKYIEERLHTLEDEKEELAQYQKWDKMRRALEY---------------TIYNQELNETRAKL 239

  Fly   258 DRIANCKAT---HAKNLAE--------VESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEA 311
            |.:::.:.|   .::.|.:        ||..|..|:|::.:|.|     :|..:.||||:|
Zfish   240 DELSSKRETCGDKSRQLRDAQQDARDKVEETERVVRELKSRISA-----MKEEKEQLSAER---- 295

  Fly   312 TATGSLKAAQGTIQQDEKKIRMASKNIEDD--------ERALAKKEADMAKVQGEFESLKEADAR 368
                     |..|:| ..|:.:.:|:::|:        :|.|.:::..:.|::.:.:.|:|.:.:
Zfish   296 ---------QEQIKQ-RTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELQETEPK 350

  Fly   369 DSKAYEDAQKKLEAVSQGLSTNE----------NGEASTLQEQLIVAKEQFSEAQTTIKTSEIEL 423
            .:...|..::.:..::|  :|.|          ..:.::.:|:....|::.......|...:.::
Zfish   351 FNTVKEKEERGIARLAQ--ATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQI 413

  Fly   424 RHTRGVLKQREGETQTNDAAYVK-DKKLH---------DQLVVEIKNLERQLQS-LDY----EGG 473
            ......|:..|...:.|...|.| |:.|:         |:...|:||.:.:||| .:|    |..
Zfish   414 AAIHKDLEDTEQNKERNLEQYNKLDQDLNEVKTRVEELDKKYYEVKNRKDELQSERNYLWREENA 478

  Fly   474 HFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKV--------RGLVGKLFQV 530
            ..:.|..:|.||..:::.|:....:...:..|...:..| :|.|:.:        .|:|...|:.
Zfish   479 EQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLE-HFRRKGINQHVINGYHGIVMNNFEC 542

  Fly   531 KDMQNSMALVQTAGGSLYSYVTDDDVTSKKIL---QRGNLQRRVTLIPINKIQSGSLNRNVVEYA 592
            :....:...| |||..|:.::.:.|..|.|||   .:.||...||.:|::|     |:.....|.
Zfish   543 EPAFYTCVEV-TAGTRLFYHIVETDEVSTKILMEFNKMNLPGEVTFLPLSK-----LDVRDTAYP 601

  Fly   593 QNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLEGDVVDP 657
            :.......:    |.:.|.:.::...|..||.||||:.:.|:.|::....::|  :|||||.|..
Zfish   602 ETNDAIPMI----SKLRYSQNFDKAFKHVFGKTLICRSMEVSTQLARAFTMDC--ITLEGDQVSH 660

  Fly   658 HGTVSGGAAPKGANVLEELHAIKQIEKEYRE---------------IDSEIAQVEKQIASIENQA 707
            .|.::||......:.||....:::.|:|..|               |::||.|:..|:..||.|.
Zfish   661 RGALTGGYYDTRKSRLELQKDMRKAEEELGELEAKLNENLRRNIETINNEIDQLMNQMQQIETQQ 725

  Fly   708 LAFNKMKENLDLRQHELTMCENRLAQT--TFQ--------------------------------- 737
               .|.|.:.|....|:.|.:.:..|:  ||.
Zfish   726 ---RKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGADLLS 787

  Fly   738 ----QNQAEIEEMRERVKTLEQ---QIIDSREK------------QKTSQAKIVDIEAKLADAKG 783
                ::|..::::.:.::.|:|   |:::.|.|            .:..:.::..:|.:|.:
Zfish   788 QLSLEDQRRVDDLNDEIRQLQQDNRQLLNERIKLEGIMTRVETYLNENLRKRLDQVEQELNE--- 849

  Fly   784 YRERE----LNAATNEIKVTKQRAEKSRANWKKREQEFETL----QLEITELQKSIETAKKQHQE 840
            .||.|    |.|.|:|:....:|.:.:.|    |.::.:||    ::||.|.|||:|..|
Zfish   850 LRETEGGTVLTATTSELDGINKRIKDTMA----RSEDLDTLIDKTEVEIKEHQKSMERWK----- 905

  Fly   841 MIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIE 905
               |:|                           |||.:.:....||: .::..::.||
Zfish   906 ---NIE---------------------------KEQNEAINHDTKEL-EKMTNRQGML------- 932

  Fly   906 LEVKKKENEQKKI---SSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKL 967
              :||||...|||   .|..:||.::.:.|..|..:...|: |    ||..........:|.::.
Zfish   933 --LKKKEECMKKIRELGSLPQEAFEKYQTLTLKQLFRKLEQ-C----NTELKKYSHVNKKALDQF 990

  Fly   968 AKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAA 1032
            ....|:|:|:        |...|..:..:|......|::.:.|.:..::..|
Zfish   991 VNFSEQKEKL--------IKRQDELDRGYKSIMELMNVLELRKYEAIQLTFK------------- 1034

  Fly  1033 TEVNTNFSGIFSSLLPGAEAKL----------------------------NPVHTNGCLTGLEIK 1069
             :|:.|||.:|..|:||.:|.|                            :.|.:....||:.|:
Zfish  1035 -QVSKNFSEVFQKLVPGGKATLVMKKGDTEGGQSQDEGEGGDSERASSSQSSVPSVDQFTGVGIR 1098

  Fly  1070 VGFNGIWKE--SLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQH 1132
            |.|.|...|  .:.:|||||||||||:|:.|:.|..|||.|:.||:|.|||..|.:....|:.:.
Zfish  1099 VSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAASDMIMEL 1163

  Fly  1133 FTNSQFLIVSLKDGLFNHANVLFRTLFEEGVSTITRQVSRQA 1174
            ..::||:..:.:..|...|:..:...|...||.|....:.||
Zfish  1164 AGHAQFITTTFRPELLESADKFYGVKFRNKVSHIDVISAEQA 1205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	305/1327 (23%)
smc3	NP_999854.1	SMC_N	2..1196	CDD:481474	306/1330 (23%)