Protein Alignment SMC2 and smc2

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_955836.2
• Gene: smc2 / 321452
• ZFINID: ZDB-GENE-030131-105
• Length: 1199
• Species: Danio rerio
• Alignment Length: 1207
• Identity: 504/1207 - (41%)
• Similarity: 787/1207 - (65%)
• Gaps: 49/1207 - (4%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            ||:|.:||:|||||..||||.||||.|.|||||||||||||||||||:||||||..|||:.||||
Zfish     1 MYIKSIVLEGFKSYAERTEINGFDPFFNAITGLNGSGKSNILDSICFLLGISNLSQVRATNLQDL 65

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            |||||.||||||||:|.|||:|..|.|.|:|...||::|||||:||:||:||||....|.:|||.
Zfish    66 VYKNGLAGITKATVSITFDNSNKKQSPLGFETHDEITITRQVVIGGRNKYLINGVNANNLRVQDL 130

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            |||:.||||||:||||||:|.:||||||.|:|:|:||||||..|:.|:.:.:..||||:.|::|.
Zfish   131 FCSVGLNVNNPHFLIMQGRITKVLNMKPPEILAMIEEAAGTRMYECKKISAQKTIEKKDAKLKEI 195

  Fly   196 KVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANE--HKIED 258
            :.:||||:.|.:.||::||::|.||||:.|:|:.|.|::::  ||..|.....:::||  .:::.
Zfish   196 QTILDEEITPAMEKLKEERASYLEYQKLMREIEHLSRLYVA--YLFVCAEETKLKSNEELQEMQS 258

  Fly   259 RIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGT 323
            .||..:....:|.|:|:.:...::|::::.|.|:||.::.||..||..:.::..|..:|...:..
Zfish   259 SIAKLQENMKQNEAKVKELSAEIQELERRRDKEVGGVLRTLEETLSEAQRVDTKAQSALDLKKQN 323

  Fly   324 IQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLS 388
            ::.:.||.:...||:|:|::.::.|||::||.....:::||...:|::|.|.||:..:|||.|||
Zfish   324 LKDETKKRKELVKNMEEDKKVMSAKEAEVAKAVERLKAVKEEGQKDAEALEAAQQHFKAVSAGLS 388

  Fly   389 TNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQ 453
            .||:|..:||..|::..|...|:|:|..|.::::|:|.:..||.::.:.:..|:.|.||:...:.
Zfish   389 ANEDGAEATLSGQMMTCKNDISKAETEAKQAQMKLKHAQQELKTKQAQVKKMDSGYKKDQDTFEA 453

  Fly   454 LVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDL---------QYQ 509
            :...|:.|:.:::.|:||.|..|.|.:       :||...||:.:...:...|         :|.
Zfish   454 VNKCIEKLQAEMKKLNYEDGREECLLE-------QKRQFSREVIQLREAYESLMGQFPNLRFEYT 511

  Fly   510 DPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRVTLI 574
            |||.|::|.||:|||..||.|.|:.|:.||...|||.||:.|.|::||.||:|::|.|:||.|:|
Zfish   512 DPERNWERSKVKGLVANLFTVTDVSNATALEVVAGGRLYNVVVDNEVTGKKLLEKGELRRRYTII 576

  Fly   575 PINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISY 639
            |:|||.:.:||.|||..|:..||.:||..|:||:.|:......|::.||.||:|..|..||::::
Zfish   577 PLNKISARTLNDNVVRTAKKLVGPDNVHTALSLVGYESELRKAMEYVFGTTLVCDSLDNAKKVAF 641

  Fly   640 DPRINCRSVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIE 704
            |..::.::|||.|||.||.||::|||..:.|:||.:|..:|.|:...|..::|::.||.:::.::
Zfish   642 DKGVSTKTVTLGGDVFDPQGTLTGGARAQTASVLSKLAEVKDIQDSLRNKEAELSAVESELSGLK 706

  Fly   705 NQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQA 769
            ..|..:.::|:.|||:..|..:.|.:|.|::|.:.|.|:|.:|:.::..|..:..::|.||.::.
Zfish   707 GTAEKYRQLKQQLDLKTEEARILETKLQQSSFHKQQEELENLRKTIEECEDTLQKTKEVQKKAEE 771

  Fly   770 KIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQK----- 829
            |...:|.|:.:|...||:||.||..::...|.:|:......|:::||.:.:.||:.||::
Zfish   772 KYNVLENKMKNAAAEREKELKAAQQKLNQAKSKADAFSKRLKEKQQEADAVALELEELKREQAGY 836

  Fly   830 -----SIETAKKQHQEMIDNL-EKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMR 888
                 :::.|.|..||.|||: .:..|..:|::|           .::.:.:||:.:..|.:|::
Zfish   837 EQQIQAVDEALKAVQEQIDNMTTEVSANKEAVRV-----------AQEKLSQQKEVIMGQEREIK 890

  Fly   889 NQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRY 953
            .:..:..::.::|.:.:|::|:.|:...|...|:.:|..::..:.|:..||..||:.||..||.|
Zfish   891 GKSGEANRLREQNNDAQLKIKELEHNISKHKKDSADATAKVARMLAENDWISSEKHLFGQPNTAY 955

  Fly   954 DYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIV 1018
            |:...:|.|||.:|.:::|.|||:||.:|..|:.:|...||.:.:.::::.||..||.||.:.|.
Zfish   956 DFKTNNPKEAGQRLKRLEETKDKLERNVNRRAMNMLSEAEERYNDLKKKKRIVENDKAKILETIE 1020

  Fly  1019 KMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGEL 1083
            ::|:::.:.||.|..:||.:|..|||:|||||.|:|.|....|.|.|||.||.....|||:|.||
Zfish  1021 ELDQKKNEALNVAWQKVNKDFGSIFSTLLPGANARLAPPEGCGVLDGLEFKVALGNTWKENLTEL 1085

  Fly  1084 SGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLF 1148
            ||||:|||||||:||||.|.|||:|||||||||||:|||||||.||:.|||:|||::||||||:|
Zfish  1086 SGGQRSLVALSLILAMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFVVVSLKDGMF 1150

  Fly  1149 NHANVLFRTLFEEGVSTITR-------QVSRQATTNK 1178
            .:|||||:|.|.:|:||:||       :|..|.|..|
Zfish  1151 TNANVLFKTKFVDGISTVTRTAQTHEGKVLAQRTQEK 1187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	494/1181 (42%)
smc2	NP_955836.2	SMC_N	2..1167	CDD:426784	495/1184 (42%)