Protein Alignment SMC2 and Smc4

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001032262.2
• Gene: Smc4 / 295107
• RGDID: 1306680
• Length: 1286
• Species: Rattus norvegicus
• Alignment Length: 1326
• Identity: 282/1326 - (21%)
• Similarity: 541/1326 - (40%)
• Gaps: 286/1326 - (21%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            :.:..:|...||||.....:..|...|:.|.|.|||||||::||:.||.|. ..|.:|:..|..|
  Rat    80 LMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKLSVL 143

  Fly    66 VYKNGQ-AGITKATVTI--------------VFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKF 115
            ::.:.: ..|...||.:              |..|:|             ..|:|.......:.:
  Rat   144 IHNSDEHTDIQSCTVEVHFQKIIDKEGDDYDVLPNSN-------------FYVSRTAYRDNTSVY 195

  Fly   116 LINGKLVQNKKVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDA 180
            .|:||....|.|.:...|..:::::..|||:||:::|:..||||   ...|...|..:|......
  Rat   196 HISGKKRTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPK---GQTEHDEGMLEYLEDIIG 257

  Fly   181 TKTLIEKKETKVRETKVLLDE--EVLPKLVKLRQERSAYQEYQKICRDIDFLI--------RIHI 235
            ...|.|..:...|..::|.:.  |.|.::..:.:|:.|.:..:.|.  |:||.        :.||
  Rat   258 CGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIA--IEFLTLENEIFKKKNHI 320

  Fly   236 SAKYLKQCETLKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLE 300
            ...|:             :.:::|||..|       .:.|.|....||:.::.:
  Rat   321 CQYYI-------------YDLQNRIAEMK-------TQKEKIHEDTKEITEKSN----------- 354

  Fly   301 TQLSAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDER--------------------AL 345
                       ..:..:||....::..|||:...:|.||.::.                    :.
  Rat   355 -----------VLSNEMKAKNSAVKDIEKKLNKVTKFIEQNKEKFTQLDLEDVQVREKLKHATSK 408

  Fly   346 AKK-EADMAKVQGEFESLKEADARD--------------SKAYEDAQKKLEAVSQGLSTNENG-- 393
            ||| |..:.|.:.:.|.||...|:.              .|..|..:|||:.|...|.....|
  Rat   409 AKKLEKQLQKDKEKVEELKSIPAKSKNVINETTTRNNSLEKEREKEEKKLKEVMDSLKQETQGLQ 473

  Fly   394 -EASTLQEQLIVAKEQFSEAQTTIKTSEIEL-----RHTRGVLKQRE--------GETQTNDAAY 444
             |....:::|:...:..:||::.::.::.||     ||...|.:..:        .||.....|.
  Rat   474 KEKEIQEKELMGFNKSVNEARSKMEVAQSELDIYLSRHNTAVSQLSKAKDALITASETLKERKAA 538

  Fly   445 VKD--KKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKREL--DRCNASRYD 505
            :||  .|| .|...|:|..|::||.|..|.   ..||...:||..:..:.|..|  :|......|
  Rat   539 IKDINTKL-PQAQQELKEKEKELQKLTQEE---INLKSLVHDLFQKVEEAKSSLATNRSRGKVLD 599

  Fly   506 LQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKK----ILQRGN 566
            ...|:.:..    ::.|:.|:|..:..:.....:..::......|:..|.:.:.:    .|::.|
  Rat   600 AIIQEKKSG----RIPGIYGRLGDLGAIDEKYDIAISSCCHALDYIVVDSIDTAQECVNFLKKHN 660

  Fly   567 LQRRVTLIPINKIQSGSLNRNVVEYAQN--------KVGAENVQWAMSLIDYDRYYEPVMKFCFG 623
            : ...|.|.::|:...:...|.::..:|        ||..|.::.|        :|     |...
  Rat   661 I-GVATFIGLDKMAVWAQKMNKIQTPENTPRLFDLVKVKNEEIRQA--------FY-----FALR 711

  Fly   624 GTLICKDLIVAKQISYDPRINCRSVTLEGDVVDPHGTVSGGAAP-----KGANVLEELHAIKQIE 683
            .||:..:|..|.:::|......|.|||:|.:::..||::||.:.     .|::|::|: :::::.
  Rat   712 DTLVANNLDQATRVAYQRDRRWRVVTLQGQIIEQSGTMTGGGSKVMRGRMGSSVVDEI-SVEEVN 775

  Fly   684 KEYREIDSEIAQVEKQIASIENQAL----AFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIE 744
            |    ::.::.:..||.|.::.|.:    |..|:|::            .|..:.|.::..|.|:
  Rat   776 K----MECQLERHSKQAAQVQEQKVQHEEAIVKLKQS------------EREMRNTLEKFTASIQ 824

  Fly   745 EMRE-------RVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQR 802
            .:.|       ::|.||..::.:...:|  |.|::             |..:|....|.....::
  Rat   825 GLSEQEEYLCVQIKELEANVLTTAPDKK--QQKLL-------------EENVNVFKKEYDAVAEK 874

  Fly   803 AEKSRANWKK-REQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEV 866
            |.|..|..|: .:...:....::...|..::|..||..|....:.|.:..:.....|...|...|
  Rat   875 AGKVEAEIKRLHDTIIDINNRKLKAQQNKLDTINKQLDECASAITKAQVAIKTADRNLKKAQDSV 939

  Fly   867 TELEQAIKEQKDKLRDQNKEMRN------QLVKK----EKML----KENQEIELEVKKKENEQKK 917
            ...|:.||:.:.::.|...|::|      :::|.    ||.|    ||::.:..|:|..::.:..
  Rat   940 CRTEKEIKDTEKEINDLKTELKNIEDNAEEVIKNTKDAEKSLPEIQKEHRALLQELKVIQDNEHA 1004

  Fly   918 ISSDAKEAKKRMEALEA---------KYPW---------IPEEKNCFGMKNTRYDYSKED----- 959
            :..||...|.::|.::.         || |         .|.|.|   ...|....|:||
  Rat  1005 LQKDALSIKLKLEQIDGHISEHNSKIKY-WQKEISKIKLHPVEDN---PVETVSVLSQEDLEAIK 1065

  Fly   960 -PHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEE 1023
             |....|::|.::.:..:|:.  |:.||....::||.:.:.....:.:..:::..::....:.::
  Rat  1066 SPDSITNQIALLEAQCREMKP--NLGAIAEYKKKEELYLQRVGELDKITSERDNFRQAYEDLRKQ 1128

  Fly  1024 EQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFN-----GIWKESLGEL 1083
            ..::.......:.......:..|..|.:|:|..|.:   |......:.|:     ..||: :..|
  Rat  1129 RLNEFMAGFYVITNKLKENYQMLTLGGDAELELVDS---LDPFSEGIMFSVRPPKKSWKK-IFNL 1189

  Fly  1084 SGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLF 1148
            |||:|:|.:|:||.|:..:.|.|||.:||:|||||..:...:...:.:...|:||:|:||::.:|
  Rat  1190 SGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMF 1254

  Fly  1149 NHANVL---FRTLFEEGVSTITRQVS 1171
            ..::.|   ::|.      .||:.|:
  Rat  1255 EISDRLIGIYKTY------NITKSVA 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	279/1314 (21%)
Smc4	NP_001032262.2	SMC_N	81..1272	CDD:426784	281/1321 (21%)