Protein Alignment SMC2 and Smc3

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_113771.2
• Gene: Smc3 / 29486
• RGDID: 62006
• Length: 1217
• Species: Rattus norvegicus
• Alignment Length: 1311
• Identity: 318/1311 - (24%)
• Similarity: 581/1311 - (44%)
• Gaps: 243/1311 - (18%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            ||:|::::.||:||..:|.::.|..:...|.|.|||||||...:|.|||. ....::|......|
  Rat     1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLS-DEFSHLRPEQRLAL 64

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            :::.....:..|.|.|:|||:: .:.|...|   |:|: |:|:...|:::.::.|:|....|.:.
  Rat    65 LHEGTGPRVISAFVEIIFDNSD-NRLPIDKE---EVSL-RRVIGAKKDQYFLDKKMVTKNDVMNL 124

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            ..|...:.:||.:::.||||.|:......:.|.::.|.|||..|..:::.:.:|:::.|.|..:.
  Rat   125 LESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKI 189

  Fly   196 KVLLD--EEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANE--HKI 256
            ..||.  ||.|..|.:.::|.:.||::.|:.|.:::               |:...|.||  .|:
  Rat   190 NELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEY---------------TIYNQELNETRAKL 239

  Fly   257 EDRIANCKATHAKNLA----------EVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKR---- 307
            ::..|..:.:..|:..          ::|.||..|:|::.:|.|     :|..:.||||:|
  Rat   240 DELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISA-----MKEEKEQLSAERQEQI 299

  Fly   308 ----ALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADAR 368
                .||..|........|..:|.::.::...|.:|..|    :|:.::|:.:.:|.|:||.:.|
  Rat   300 KQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE----EKQKELAETEPKFNSVKEKEER 360

  Fly   369 D-SKAYEDAQKKLEA-VSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLK 431
            . ::..:..|::.:. ..||    ...:.::.:|:....|::.......|...:.::......|:
  Rat   361 GIARLAQATQERTDLYAKQG----RGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLE 421

  Fly   432 QREGETQTNDAAYVK-DKKLH---------DQLVVEIKNLERQLQS-LDY----EGGHFEKLKQR 481
            ..|...:.|...|.| |:.|:         |:...|:||.:.:||| .:|    |....:.|..:
  Rat   422 DTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAK 486

  Fly   482 RNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKV--------RGLVGKLFQVKDMQNSMA 538
            |.||..:::.|:....:...:..| .......:|.|:.:        .|:|...|:.:....:..
  Rat   487 REDLEKKQQLLRAATGKAILNGID-SINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCV 550

  Fly   539 LVQTAGGSLYSYVTDDDVTSKKIL---QRGNLQRRVTLIPINKIQSGSLNRNVVEYAQNKVGAEN 600
            .| |||..|:.::.|.|..|.|||   .:.||...||.:|:||     |:.....|.:.......
  Rat   551 EV-TAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNK-----LDVRDTAYPETNDAIPM 609

  Fly   601 VQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLEGDVVDPHGTVSGGA 665
            :    |.:.|:..::...|..||.||||:.:.|:.|::....::|  :|||||.|...|.::||.
  Rat   610 I----SKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDC--ITLEGDQVSHRGALTGGY 668

  Fly   666 APKGANVLEELHAIKQIEKEYRE---------------IDSEIAQVEKQIASIENQALAFNKMKE 715
            .....:.||....:::.|:|..|               |::||.|:..|:..||.|.   .|.|.
  Rat   669 YDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQ---RKFKA 730

  Fly   716 NLDLRQHELTMCENRLAQT--TFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKL 778
            :.|....|:.|.:.:..|:  ||...|..::.:...:..:|    .:||..|......:..:..|
  Rat   731 SRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAME----STRESLKAELGTDLLSQLSL 791

  Fly   779 ADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLE--IT--------ELQKSIET 833
            .|     ::.::|..:||:..:|         :.|:...|.::||  ||        .|:|.::.
  Rat   792 ED-----QKRVDALNDEIRQLQQ---------ENRQLLNERIKLEGIITRVETYLNENLRKRLDQ 842

  Fly   834 AKKQHQEMIDN-----LEKFKAELDAL--KVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQL 891
            .:::..|:.:.     |....:||:|:  :|..:.|.||  :|:.:|    ||.....||::..:
  Rat   843 VEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSE--DLDNSI----DKTEAGIKELQKSM 901

  Fly   892 VKKEKMLKENQEI------ELE---------VKKKENEQKKI---SSDAKEAKKRMEALEAKYPW 938
            .:.:.|.||:.:.      |||         :||||...|||   .|..:||.::.:.|..|..:
  Rat   902 ERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLF 966

  Fly   939 IPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEE---NFKETE 1000
            ...|: |    ||..........:|.::.....|:|:|:           :.|:||   .:|...
  Rat   967 RKLEQ-C----NTELKKYSHVNKKALDQFVNFSEQKEKL-----------IKRQEELDRGYKSIM 1015

  Fly  1001 RRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKL----------- 1054
            ...|::.:.|.:..::..|              :|:.|||.:|..|:||.:|.|
  Rat  1016 ELMNVLELRKYEAIQLTFK--------------QVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQ 1066

  Fly  1055 ------------------NPVHTNGCLTGLEIKVGFNGIWKE--SLGELSGGQKSLVALSLVLAM 1099
                              :.|.:....||:.|:|.|.|...|  .:.:|||||||||||:|:.|:
  Rat  1067 SQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAI 1131

  Fly  1100 LKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTLFEEGVS 1164
            .|..|||.|:.||:|.|||..|.:.:..|:.:...::||:..:.:..|...|:..:...|...||
  Rat  1132 QKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVS 1196

  Fly  1165 ---TITRQVSR 1172
               .||.::::
  Rat  1197 HIDVITAEMAK 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	313/1295 (24%)
Smc3	NP_113771.2	SMC_N	2..1197	CDD:426784	314/1298 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..268		2/25 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1059..1090		1/30 (3%)