Protein Alignment SMC2 and psm1

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_596049.2
• Gene: psm1 / 2540557
• PomBaseID: SPBC29A10.04
• Length: 1228
• Species: Schizosaccharomyces pombe
• Alignment Length: 1332
• Identity: 299/1332 - (22%)
• Similarity: 563/1332 - (42%)
• Gaps: 286/1332 - (21%)

  Fly     5 KLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKN 69
            :|.::.|||| |..:|.|...:||:|.|.||:||||::|:|.||||:.: .::|::.:::|:|:
pombe     6 RLEVENFKSY-RGHQIIGPFEDFTSIIGPNGAGKSNLMDAISFVLGVKS-SHLRSTNVKELIYR- 67

  Fly    70 GQAGITKATVTIVFDNTNP--AQCPQGYE----KCREISVTRQVVVGGKNKFLINGKLVQNKKVQ 128
              ..|.:...|...|::||  |.....||    :.||..  |.:...|..::.|:.::|...:
pombe    68 --GKILQRDNTDFTDSSNPTTAYVKLMYELDNGEQREYK--RAITPSGATEYKIDEEIVTFSE-- 126

  Fly   129 DFFC-SIQ---LNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKE 189
              :| |:|   :.|...|||:.||.::.:.:..|.|:..:||:.:|:.:||::.|.:|...:|
pombe   127 --YCGSLQKENILVRARNFLVFQGDVETIASQSPLELSKLVEQISGSLEYKSEYDKSKDEQDK-- 187

  Fly   190 TKVRETKVLLDEEVLPKLVKLRQERSAYQEY---------QKICRDIDFLIRIHISAKYLKQCET 245
                  .|.|......|...:..|...|||.         ||..||...|:.:.....:|
pombe   188 ------AVNLSAHSFNKKRGINAELRQYQEQKTEAERYQSQKEKRDSAQLVYLLWKLFHL----- 241

  Fly   246 LKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALE 310
                   |..|...:|......|.::..:|..:.:.||:::..:.|  |||:.
pombe   242 -------EKSISSNMAEVTRLKADSIQLIERRDENTKEIEKLKEKE--GSIRR------------ 285

  Fly   311 ATATGSLKAAQGTIQQDEKKIRMASKN---IEDDERALAKKEADMAKVQGEFESLKEADARDSKA 372
                 :|.|....:::.||.|  |||.   |...|:||..| :::.|:|.:...::       |.
pombe   286 -----NLLAFDRKVRKQEKLI--ASKRPELISIAEKALESK-SNLRKIQRKAAEIE-------KD 335

  Fly   373 YEDAQKKLEAVSQGLSTNENGEASTLQEQ-----------LIVAKEQF----SEAQTTIKTSEIE 422
            |.|....|:.:...|::....|...|::.           |...||::    |||.........:
pombe   336 YSDQASTLQVLENQLTSLSAAEKEFLKDMQEKEQLKGLRLLPEDKEEYEGLRSEADKLNSNLLFK 400

  Fly   423 L----RHTRGVLKQREGETQTNDAAYVKDKKLHD---QLVVE----IKNLERQLQSLDYEGGHFE 476
            |    |:.:...:.::..|........|.|.||:   .|..|    :..:..:::||:.|....:
pombe   401 LQTLNRNIKVTSQSKDSLTSIVGDLESKIKSLHESVSSLDTERADLLAKINEKIESLELEKHDQQ 465

  Fly   477 KLKQRRNDLHMRKRDLKRELDRC-----------NASRYDLQYQD---------PEPNFDRRKVR 521
            |.:...::|..:.::|..||..|           |.|:.|.:.::         ||       |:
pombe   466 KKRLTYSELFHKTQELNEELQSCLQKILEASADRNESKQDAKKREALYALKRIYPE-------VK 523

  Fly   522 GLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQR--RVTLIPINKIQSGSL 584
            |.:..|......:...|:....|.:..:.|.:....:|:.:.....||  .:|..|::.|.:..:
pombe   524 GRIIDLCTPTQKKYESAIAAALGKNFDAIVVETQAVAKECIDYIKEQRIGIMTFFPMDTIAASPV 588

  Fly   585 NRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVT 649
            |:   ::.....||   :.|:.:::::..||.||....|.||||..:.||:.:||:.|:|.::||
pombe   589 NQ---KFRGTHKGA---RLAIDVLNFESEYERVMISAVGNTLICDSMTVARDLSYNKRLNAKTVT 647

  Fly   650 LEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIAS---IENQALAFN 711
            |||.|:...|.::||::...:....:.|....:.:....:..:|.::|.|.:|   .|:..:..:
pombe   648 LEGTVIHKTGLITGGSSNNRSAKHWDDHDFDLLTQTKDRLMHQIGEIEYQKSSCVITESDTVKLH 712

  Fly   712 KMKENLDLRQHELTMCENRLAQTTFQQNQAE--IEEMRERVKTLEQQIIDSREKQKTSQAKIVDI 774
            .::..:.|.:.:.|:....:.....:....|  |:|.:..:..||.::.:..:.:...|.::..:
pombe   713 SLESEISLLKDKYTVVSRSVEDKKKEIGHYESLIKEKQPHLSELEMELRNFVKSRDELQIQVEKV 777

  Fly   775 EAK----------LADAKGYRE--RELNAA--TNEIKVTKQRA-EKSRANWKKREQEFETLQLEI 824
            |.|          ::|...|.|  |....:  ..:::.|||:: .::|.:::|  |.....:|.:
pombe   778 EEKIFSGFCKRIGISDIHTYDEIHRTFTQSFTQKQLEFTKQKSLLENRISFEK--QRVSDTRLRL 840

  Fly   825 TELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRN 889
            ..:.|.||    :.||.|||.|:          |..:..|||...|..::..|:....:|.
pombe   841 ERMHKFIE----KDQESIDNYEQ----------NREALESEVATAEAELELLKEDFASENS---- 887

  Fly   890 QLVKKEKMLKENQEIELEVKKKENEQKKISSD----------------AKEAKKRMEAL------ 932
               |.||:|....|.:|..|:..:|..|:|.:                |...|.::|.:
pombe   888 ---KTEKILLAASEKKLVGKRLVSELTKLSGNITLLESEIDRYVSEWHAILRKCKLEDIDVPLRE 949

  Fly   933 ---------------------EAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNK--LAKMQEK- 973
                                 |...|.|..||  ||:: ..||...|:....|::  .:.:|||
pombe   950 GSLTSIPIDDVSNSGDITMGEEPSEPVINFEK--FGVE-VDYDELDEELRNDGSESMASVLQEKL 1011

  Fly   974 KDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTN 1038
            ::..|.         ||:...|.:..||        .|.::..:.|:|||.. ...|||......
pombe  1012 REYSEE---------LDQMSPNLRAIER--------LETVETRLAKLDEEFA-AARKAAKNAKER 1058

  Fly  1039 FSGI-------FSSLLPGAEAKLNPVHT------------NGCLTGLEIKVGFNGIWK------- 1077
            |:.:       |.:.......:::|::.            ...||..::...:.|..|
pombe  1059 FNAVKQKRLQKFQAAFSHISEQIDPIYKELTKSPAFPLGGTAYLTLDDLDEPYLGGIKFHAMPPM 1123

  Fly  1078 ---ESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNS-QF 1138
               ..:.:||||:|::.||:|:.|:..:.|:|.::|||:|||||.::...|.:.::||.::. ||
pombe  1124 KRFRDMDQLSGGEKTMAALALLFAIHSYQPSPFFVLDEIDAALDQTNVTKIANYIRQHASSGFQF 1188

  Fly  1139 LIVSLKDGLFNHANVL---FRTLFEEGVSTIT 1167
            :::|||:.||:.:..|   :|...|....|::
pombe  1189 VVISLKNQLFSKSEALVGIYRDQQENSSRTLS 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	298/1325 (22%)
psm1	NP_596049.2	SMC_N	6..1207	CDD:481474	296/1317 (22%)