Protein Alignment SMC2 and SMC5

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_055925.2
• Gene: SMC5 / 23137
• HGNCID: 20465
• Length: 1101
• Species: Homo sapiens
• Alignment Length: 1200
• Identity: 250/1200 - (20%)
• Similarity: 469/1200 - (39%)
• Gaps: 255/1200 - (21%)

  Fly     3 VKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVY 67
            :.::.::.|.:|.......|  |....|.|.||:|||:|:.:||  ||::........|  |.|.
Human    53 IVRISMENFLTYDICEVSPG--PHLNMIVGANGTGKSSIVCAIC--LGLAGKPAFMGRA--DKVG 111

  Fly    68 KNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKF-LINGKLVQNKKVQDFF 131
            ...:.|.::..|.|           :.:.....:.:||::.|.....| .||.|....|.|::..
Human   112 FFVKRGCSRGMVEI-----------ELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKV 165

  Fly   132 CSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETK 196
            .::.:.|.|....:.|.|:.:...:...|:|...|::.|..:........|.|.||:  |..||.
Human   166 AALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKE--KQLETS 228

  Fly   197 VLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIA 261
            .....|.|.|:|: |.||  |::      |::   |.:...::|   :.::.:||....:|  ..
Human   229 CKEKTEYLQKMVQ-RNER--YKQ------DVE---RFYERKRHL---DLIEMLEAKRPWVE--YE 276

  Fly   262 NCKATHAKNLAEVESIENSVKEMQQQID----------AEMGGSIKNLETQLSAKRALEATATGS 316
            |.:    :...||:.:.:.|||..:::.          .||.....|||.::..|      || .
Human   277 NVR----QEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEK------AT-D 330

  Fly   317 LKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLE 381
            :|.|....:|.:..|....|:||:.::||..|:.:            |.|.:  :...:.:|.:|
Human   331 IKEASQKCKQKQDVIERKDKHIEELQQALIVKQNE------------ELDRQ--RRIGNTRKMIE 381

  Fly   382 AVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVK 446
            .:...|.|.||.|  .||.|:..........|......|.|:     :.|:||.||      ..|
Human   382 DLQNELKTTENCE--NLQPQIDAITNDLRRIQDEKALCEGEI-----IDKRRERET------LEK 433

  Fly   447 DKKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDP 511
            :||..|..:|...||..|.:         :||:||..|.:.....|:...|:
Human   434 EKKSVDDHIVRFDNLMNQKE---------DKLRQRFRDTYDAVLWLRNNRDK------------- 476

  Fly   512 EPNFDRRKVRGLVGKLFQVKDMQNSMALV-QTAGGSLYSYV----TDDDVTSKKILQRGNLQRRV 571
               |.:|....:: ....:||.:|:..:. ......|.::|    .|.:|..|::.....|:...
Human   477 ---FKQRVCEPIM-LTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNA 537

  Fly   572 TLIP----INKIQSGSLNR----NVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLIC 628
            .:.|    .:|..|.|||.    ....|.:....|.:...:.....|..:..||      ||...
Human   538 VIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPV------GTEKT 596

  Fly   629 KDLIVAKQISYDPRINCRSVTLEGDVVD----PHGTVSGGAAPKGANVLEELHAIKQIEKEYREI 689
            ::.|  :::..:.|:.......|..||.    .:..:|...:.|.|..|.....::|    .|.:
Human   597 RERI--ERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQ----RRHL 655

  Fly   690 DSEIAQVEKQIASIENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLE 754
            :.::.::.:::.::::..:|..:..::|:.:.:||            :|.:.|:.|.:.:.:.||
Human   656 EEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNEL------------RQKKKELLERKTKKRQLE 708

  Fly   755 QQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFET 819
            |:|     ..|....|:::     .|.....|.|..|:|...::..|:|:.
Human   709 QKI-----SSKLGSLKLME-----QDTCNLEEEERKASTKIKEINVQKAKL-------------- 749

  Fly   820 LQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQN 884
                :|||...|:.....|.:.:|           |.:.:::..||..:||........:||
Human   750 ----VTELTNLIKICTSLHIQKVD-----------LILQNTTVISEKNKLESDYMAASSQLR--- 796

  Fly   885 KEMRNQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRM---------EALEAKY---- 936
                         |.|...|||:    ||.|:.:.. .||..||.         :.|..:|
Human   797 -------------LTEQHFIELD----ENRQRLLQK-CKELMKRARQVCNLGAEQTLPQEYQTQV 843

  Fly   937 PWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLD---REEENFKE 998
            |.||.     |..::.....::.|:......|.:.|::.:......:|..:|.:   ||||..:.
Human   844 PTIPN-----GHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQL 903

  Fly   999 TERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNG-- 1061
            ||..:. ..::.::.::.|.::.|...:.|.:...::|..||..|||:....|..|   ||..
Human   904 TEELKG-KKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDL---HTENEE 964

  Fly  1062 --CLTGLEIKVGFNGIWKESLGEL-----SGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDM 1119
              ...|:.|:|.|..  ...|.||     |||::|:..:..::|:.:.:..|..::||::..:|.
Human   965 DYDKYGIRIRVKFRS--STQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDP 1027

  Fly  1120 SHTQNIGSML-----KQHFTNSQFLIVSLK 1144
            .:.:.:..|:     |::  .||:..::.|
Human  1028 INERRVFEMVVNTACKEN--TSQYFFITPK 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	249/1199 (21%)
SMC5	NP_055925.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43
		P-loop containing Nucleoside Triphosphate Hydrolases	51..>196	CDD:476819	36/159 (23%)
		SMC_prok_B	196..1053	CDD:274008	213/1036 (21%)
		Flexible hinge	446..646		43/233 (18%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<975..1077	CDD:476819	18/84 (21%)