Protein Alignment SMC2 and Smc5

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001413081.1
• Gene: Smc5 / 226026
• MGIID: 2385088
• Length: 1102
• Species: Mus musculus
• Alignment Length: 1201
• Identity: 250/1201 - (20%)
• Similarity: 473/1201 - (39%)
• Gaps: 256/1201 - (21%)

  Fly     3 VKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVY 67
            :.::.::.|.:|.......|  |....|.|.||:|||:|:.:||  ||::........|  |.|.
Mouse    53 IVRIAMENFLTYDICEVSPG--PHLNMIIGANGTGKSSIVCAIC--LGLAGKPAFMGRA--DKVG 111

  Fly    68 KNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQV-VVGGKNKFLINGKLVQNKKVQDFF 131
            ...:.|.:|..|.|....|:           ..:.:||:: |:..::.:.||.|.|..|.|::..
Mouse   112 FFVKRGCSKGLVEIELFRTS-----------GNLIITREIDVIKNQSFWFINKKPVTQKIVEEQV 165

  Fly   132 CSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETK 196
            .::.:.|.|....:.|.|:.:...:...|:|...|::.|..:........|...||:  |..||.
Mouse   166 AALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSVGPPEMHRYHCELKNFREKE--KQLETS 228

  Fly   197 VLLDEEVLPKLVKLRQER--SAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDR 259
            .....|.|.|:|: |.||  ...:.:.:..|.:|.:..:.....:: :.|.::........|.||
Mouse   229 CKEKTEYLEKMVQ-RNERYKQDVERFYERKRHLDLIEMLEAKRPWV-EYENVRQEYEGVKLIRDR 291

  Fly   260 IANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTI 324
            :..          ||..::.....|.::|: |:......||.::..|       :..:|.|....
Mouse   292 VKE----------EVRKLKEGQIPMTRRIE-EIDRQRHTLEVRIKEK-------STDIKEASQKC 338

  Fly   325 QQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLST 389
            :|.:..|....:.|::.::||..|:.:            |.|.:  |...:.:|.:|.:...|.|
Mouse   339 KQRQDLIERKDRQIKELQQALTVKQNE------------ELDRQ--KRISNTRKMIEDLQSELKT 389

  Fly   390 NENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKK-LHDQ 453
            .||.|  .||.|:                                 :|.|||...|:::| |.:.
Mouse   390 AENCE--NLQPQI---------------------------------DTVTNDLRRVQEEKALCEG 419

  Fly   454 LVV----EIKNLERQLQSLDYEGGHFEKLKQRRND-LHMRKRDLKRELDRCNASRYD--LQYQDP 511
            .::    |.:.||:|.:|:......|:.|..::.| |..|.||           .||  |..::.
Mouse   420 EIIDKQREKEMLEKQRRSVSDHITRFDNLMNQKEDKLRQRYRD-----------TYDAVLWLRNN 473

  Fly   512 EPNFDRRKVRGLVGKLFQVKDMQNSMALV-QTAGGSLYSYVTDDDVTSKKILQ--RGNLQRRVTL 573
            ...|.:|....:: ....:||.:|:..:. ..:...|.::|.:.....:..|:  |.|.:.||..
Mouse   474 RDRFKQRVCEPIM-LTINMKDNKNAKYVENHISSNDLRAFVFESQEDMEIFLREVRDNKKLRVNA 537

  Fly   574 IPINKIQ------SGSLN----RNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLIC 628
            :...||.      |.|||    .....|.:....|.:...:.....|..:..||      ||...
Mouse   538 VIAPKISYADKAPSRSLNDLKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPV------GTERT 596

  Fly   629 KDLIVAKQISYDPRINCRSVTLEGDV----VDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREI 689
            ::.|  :::..:.|:.......|..|    |..:..:|...:.|.|..|.....::|    .|.:
Mouse   597 RERI--ERVIQETRLKQIYTAEEKYVLKTSVYSNKVISSNTSLKVAQFLTVTVDLEQ----RRHL 655

  Fly   690 DSEIAQVEKQIASIENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLE 754
            :.::.::.:|:.::::...|......:|:|:.:||.:            .:.|:.|.:.|.:.||
Mouse   656 EEQLKEMNRQLEAVDSGLAALRDTNRHLELKDNELRL------------KKKELLERKTRKRQLE 708

  Fly   755 QQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFET 819
            |:|          .:|:..|.....|.....|.|..|:|...::..|:|:
Mouse   709 QKI----------SSKLASIRLMEQDTCNLEEEERKASTKIKEINVQKAK--------------- 748

  Fly   820 LQLEITELQKSIETAKKQHQEMI-DNL----EKFKAELDALKVNSSSAASEVTELEQAIKEQKDK 879
            |..|:|.|.|...:.:.|..::| .|.    ||.|.|.|.:   :||:...||| :|.|:
Mouse   749 LVTELTGLVKICTSFQIQKVDLILQNTTVISEKNKLEADYM---ASSSQLRVTE-QQFIE----- 804

  Fly   880 LRDQNKEMRNQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKN 944
             .|.|   |.:|::|.|          |:.||..:...:|:|....::    .:.:.|.||.
Mouse   805 -LDDN---RQRLLQKCK----------ELMKKARQVCNLSADQAVPQE----FQTQVPTIPN--- 848

  Fly   945 CFGMKNTRYDYSKEDP---HEAGNKL----AKMQEKKDKMERTLNMNAIMVLDREEENFKETERR 1002
                     .:|...|   .:..|.|    |.:.|::.:......:|..:|:  ||.:.:|.|.:
Mouse   849 ---------GHSSSPPMAFQDLPNTLDEIDALLTEERSRASCFTGLNPSVVV--EEYSKREVEIQ 902

  Fly  1003 RNIVAMDKEKI-----KKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNG- 1061
            :....:..:|:     ::.|.::.|...:.|.:...::|..||..|||:....|..|   ||..
Mouse   903 QLTEELQGKKVELDEYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDL---HTENE 964

  Fly  1062 ---CLTGLEIKVGFNGIWKESLGEL-----SGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALD 1118
               ...|:.|:|.|..  ...|.||     |||::|:..:..::|:.:.:..|..::||::..:|
Mouse   965 EDYDKYGIRIRVKFRS--STQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMD 1027

  Fly  1119 MSHTQNIGSML-----KQHFTNSQFLIVSLK 1144
            ..:.:.:..|:     |::  .||:..::.|
Mouse  1028 PINERRVFEMVVNTACKEN--TSQYFFITPK 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	250/1201 (21%)
Smc5	NP_001413081.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44
		P-loop containing Nucleoside Triphosphate Hydrolases	51..>196	CDD:476819	38/159 (24%)
		SMC_prok_B	196..1054	CDD:274008	211/1037 (20%)
		Flexible hinge	441..644		43/222 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<976..1078	CDD:476819	19/85 (22%)